anti-Ring Finger and FYVE-Like Domain Containing 1 (RFFL) Antibodies

Has E3 ubiquitin protein ligase activity. Additionally we are shipping RFFL Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RFFL 67338 Q6ZQM0
RFFL 117584 Q8WZ73
RFFL 282844 Q8CIN9
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Top anti-RFFL Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RFFL Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: THP-1 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Rffl Antibody Titration: 1.0 ug/ml Positive Control: Mouse Liver 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated EIA, IHC (p), WB   0.5 mg 4 to 8 Days
$715.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with RFFL antibody ABIN214375 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-RFFL antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Horse Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB RFFL Antibody (C-term) (ABIN1881744) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the RFFL antibody detected the RFFL protein (arrow). 400 μL 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western Blot analysis of RFFL expression in transfected 293T cell line by RFFL monoclonal antibody (M01), clone 3A4.Lane 1: RFFL transfected lysate(36.6 KDa).Lane 2: Non-transfected lysate. Western blot analysis of RFFL over-expressed 293 cell line, cotransfected with RFFL Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with RFFL monoclonal antibody (M01), clone 3A4. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 to 12 Days
$440.00
Details
Cow Rabbit Un-conjugated EIA, IF, IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot using Protein A Purified anti-RFFL antibody shows detection of RFFL (arrowhead) in lysate. Lanes correspond to empty vector 293T cell lysate (mock, left); RNF34 transfected lysate (middle) and RFFL transfected lysate (right), are shown using 20 µl of lysate per lane. Lysates were prepared from equivalent numbers of cells. Data presented demonstrate that this reagent is specific for RFFL. After SDS-PAGE and transfer, the membrane was probed with the primary antibody diluted to 1:1,000 using 5% BLOTTO, 0.1% Tween-20 in PBS as the diluent. Incuba-tion occurred for 1 h at room temperature. Personal Communication, Srinivasa Srinivasula, CCR-NCI, Bethesda, MD. 500 μg 5 to 7 Days
$688.50
Details

Top referenced anti-RFFL Antibodies

  1. Human Polyclonal RFFL Primary Antibody for WB - ABIN1881744 : Newton-Cheh, Eijgelsheim, Rice, de Bakker, Yin, Estrada, Bis, Marciante, Rivadeneira, Noseworthy, Sotoodehnia, Smith, Rotter, Kors, Witteman, Hofman, Heckbert: Common variants at ten loci influence QT interval duration in the QTGEN Study. in Nature genetics 2009 (PubMed)
    Show all 5 Pubmed References

  2. Polyclonal RFFL Primary Antibody for IHC (p), ELISA - ABIN539474 : McDonald, El-Deiry: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 3 Pubmed References

  3. Cow (Bovine) Polyclonal RFFL Primary Antibody for WB - ABIN2775666 : Hanuszkiewicz, Pittock, Humphries, Moll, Rosales, Molinaro, Moynagh, Lajoie, Valvano: Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against RFFL Interaction Partners

Mouse (Murine) Ring Finger and FYVE-Like Domain Containing 1 (RFFL) interaction partners

  1. EGF, which signals through CRAF, and an activated BRAF mutant also activate PKC and stimulate cell migration through up-regulating RFFL expression.

  2. Data show that the the amino-terminal domain of rififylin is critical for its recruitment to recycling endocytic membranes and for the inhibition of recycling.

  3. CARP2 [Rififylin] deficiency does not alter induction of NF-kappaB by TNFalpha.

Human Ring Finger and FYVE-Like Domain Containing 1 (RFFL) interaction partners

  1. RFFL is an important regulator of voltage-gated hERG potassium channel activity and therefore cardiac repolarization and that this ubiquitination-mediated regulation requires parts of the ERAD pathway.

  2. it is interesting to note that a human lncRNA does exist within the 5'-UTR intronic region of the human RFFL gene . Given the rat data, our study may serve as a translational foundation for considering this human lncRNA as a candidate regulator for cardiovascular diseases.

  3. EGF, which signals through CRAF, and an activated BRAF mutant also activate PKC and stimulate cell migration through up-regulating RFFL expression.

  4. data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner.

  5. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death.

  6. acts at the level of endocytic vesicles to limit the intensity of TNF-induced NF-kappaB activation by the regulated elimination of a necessary signaling component within the receptor complex

RFFL Antigen Profile

Protein Summary

Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates (By similarity). Overexpression slows protein traffic through recycling endosomes.

Gene names and symbols associated with RFFL

  • ring finger and FYVE like domain containing E3 ubiquitin protein ligase (RFFL) antibody
  • ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog (rffl.L) antibody
  • ring finger and FYVE-like domain containing 1 (Rffl) antibody
  • ring finger and FYVE like domain containing protein (Rffl) antibody
  • ring finger and FYVE-like domain containing E3 ubiquitin protein ligase (Rffl) antibody
  • 1700051E09Rik antibody
  • 4930516L10Rik antibody
  • BG080975 antibody
  • CARP-2 antibody
  • CARP2 antibody
  • FRING antibody
  • MGC84042 antibody
  • Rffl antibody
  • RIFIFYLIN antibody
  • RNF34L antibody
  • RNF189 antibody

Protein level used designations for RFFL

E3 ubiquitin-protein ligase rififylin , ring finger and FYVE-like domain containing 1 , rififylin , e3 ubiquitin-protein ligase rififylin-like , RING finger and FYVE-like domain-containing protein 1 , fring , FYVE-RING finger protein SAKURA , RING finger protein 189 , caspase regulator CARP2 , caspases-8 and -10-associated RING finger protein 2 , FYVE-RING finger protein Sakura , RING finger protein SAKURA , ring finger and FYVE like domain containing protein

GENE ID SPECIES
417529 Gallus gallus
447349 Xenopus laevis
454582 Pan troglodytes
491144 Canis lupus familiaris
530263 Bos taurus
100058179 Equus caballus
100115488 Nasonia vitripennis
100464760 Ailuropoda melanoleuca
100604408 Nomascus leucogenys
67338 Mus musculus
117584 Homo sapiens
282844 Rattus norvegicus
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