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Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. Additionally we are shipping ROBO4 Antibodies (118) and ROBO4 Kits (8) and many more products for this protein.
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Low expression level of ROBO4 is associated with evasive resistance and disease progression in cancer.
GM-CSF (show CSF2 Proteins) and IL-1beta (show IL1B Proteins). Taken together, we demonstrated novel Robo4 functions in inflammation, i.e., it promotes IL-6 (show IL6 Proteins) production by endothelial cells and immune cells via crosstalk.
Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (show SP1 Proteins) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (show PSG1 Proteins)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.
there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy
These results suggest that Slit2/Robo1 binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 may function by interacting with CdGAP in HUVECs.
results indicate that AP-1 (show FOSB Proteins) complexes regulate Robo4 gene expression in endothelial cells
BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (show RUNX1 Proteins) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.
Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and FAK (show PTK2 Proteins) signaling pathways.
Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (show HIF1A Proteins) suggesting that Robo4 is positively regulated by HIF-1alpha (show HIF1A Proteins) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.
Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (show CPB1 Proteins)
endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.
Robo4 vaccines induce antibodies that retard tumor growth.
Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.
These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.
our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms
Data found that expression of Slit2 (show SLIT2 Proteins) and SDF1 (show CXCL12 Proteins) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.
augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis
Robo4 specifically binds to UNC5B (show UNC5B Proteins), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF (show VEGF Proteins))-R2 signaling through the Src (show SRC Proteins) and FAK (show PTK2 Proteins) kinases.
Sox7 (show SOX7 Proteins) and Sox18 (show SOX18 Proteins)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.
Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
roundabout homolog 4
, roundabout homolog 4, magic roundabout
, Magic roundabout
, magic roundabout