Runt-Related Transcription Factor 1 Proteins (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (285) and RUNX1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,263.33
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,300.00
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$480.00
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Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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RUNX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Top referenced RUNX1 Proteins

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

More Proteins for Runt-Related Transcription Factor 1 (RUNX1) Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF (show ZBTB16 Proteins).

  2. Study reveals a previously unrecognized synergism between ETV6 (show ETV6 Proteins)/RUNX1 and BCL2 (show BCL2 Proteins) impacting on malignant disease and autoimmunity.

  3. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

  4. The findings suggest that the absence of uPA (show PLAU Proteins) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  5. Flt3 and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development.

  6. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (show AQP5 Proteins) protein of the acinar cells in the SMG (show SNRPG Proteins) in order to allow for the proper secretion of saliva (show RAG1AP1 Proteins)

  7. High RUNX1 expression is associated with skin squamous cell carcinoma.

  8. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Proteins)- and NOTCH1 (show NOTCH1 Proteins)-regulated genes, including the MYB (show MYB Proteins) and MYC (show MYC Proteins) oncogenes, respectively.

  9. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  10. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. The here presented transcriptomic subgroup-based approach unified the gene expression profiles of RUNX1-CBFA2T3 (show CBFA2T3 Proteins) and RUNX1-RUNX1T1 (show RUNX1T1 Proteins) acute myeloid leukemia (show BCL11A Proteins).

  2. Platelet CD34 (show CD34 Proteins) expression and alpha/delta-granule abnormalities in GFI1B (show GFI1B Proteins)- and RUNX1-related familial bleeding disorders.

  3. We observed a strong correlation between EVI1 (show MECOM Proteins) and alpha1, 6-fucosyltransferase (FUT8 (show FUT8 Proteins)) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.

  4. A novel function of RUNX1 and offer an explanation for the link between RUNX1 mutations and chemotherapy and radiation resistance. Moreover, these data suggest that pharmacologic modulation of RUNX1 might be an attractive new approach to treat hematologic malignancies.

  5. high EVI1 (show MECOM Proteins) expression might predict high risk of relapse in AML patients undergoing myeloablative allo-HSCT in CR1.

  6. Hypermethylation of the CTNNA1 (show CTNNA1 Proteins) promoter was associated with unfavorable karyotype, and possessed the higher frequency of coexisting with ASXL1 (show ASXL1 Proteins) and RUNX1 mutations.

  7. Three siblings with germline causative RUNX1 variant, developed acute myelomonocytic leukemia and acquired variants within the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway, specifically targeting JAK2 (show JAK2 Proteins) and SH2B3 (show SH2B3 Proteins).

  8. These findings suggest RUNX1high is a prognostic biomarker of unfavorable outcome in cytogenetically normal acute myeloid leukemia (show BCL11A Proteins)

  9. 3 di ff erent heterozygous mutations segregated with thrombocytopenia in 3 families: one missense (c.578T > A/p.Ile193Asn) variant a ff ecting a well conserved residue of the runt-homologous domain, 2 nucleotide substitutions of the canonical "gt" dinucleotide in the donor splice sites of intron 4, (c.351 1 1G > A) and intron 8 (c.967 1 2_5del), and 2 alternative spliced products affecting the transactivation domain.

  10. Here, we report the first identification of H3(K27M) and H3(K27I) mutations in patients with AML. We find that these lesions are major determinants of reduced H3K27me2/3 in these patients and that they are associated with common aberrations in the RUNX1 gene.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Proteins) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Proteins) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 (show RUNX3 Proteins) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Proteins) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (runx1)
  • runt related transcription factor 1 L homeolog (runx1.L)
  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 protein
  • aml protein
  • aml-1 protein
  • Aml1 protein
  • aml1-evi-1 protein
  • amlcr1 protein
  • cbfa2 protein
  • evi-1 protein
  • Pebp2a2 protein
  • pebp2ab protein
  • Pebpa2b protein
  • Runx-1 protein
  • runx1 protein
  • runxa protein
  • XAML protein
  • Xaml1 protein

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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