Runt-Related Transcription Factor 1 Proteins (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (327) and RUNX1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top RUNX1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human RUNX1 Protein. 100 μg Log in to see 11 to 18 Days
$483.26
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,263.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,300.00
Details
Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

RUNX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Top referenced RUNX1 Proteins

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

More Proteins for Runt-Related Transcription Factor 1 (RUNX1) Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. The promoter regions of Runx1 is targets of STAT4 (show STAT4 Proteins) and that STAT4 (show STAT4 Proteins) binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

  2. Results suggest that AML1/ETO (show RUNX1T1 Proteins) expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  3. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC (show FUT1 Proteins) emergence.

  4. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (show NFE2 Proteins) and either RUNX1, FLI1 (show FLI1 Proteins) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  5. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT (show CBFA2T2 Proteins)) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  6. CDK6 (show CDK6 Proteins) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  7. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  8. These results suggest that RUNX1 may be an essential modulator in BMP9 (show GDF2 Proteins)- induced osteogenic differentiation of mesenchymal stem cells.

  9. Loss of Runx1 and Runx2 (show RUNX2 Proteins) inhibits prostate cell motility.

  10. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. specific type of RUNX1 mutation did not affect its association pattern with trisomy 21

  2. High RUNX1 expression is associated with prostatic cancer.

  3. RUNX1 Mutation is associated with acute myeloid leukemia (show BCL11A Proteins).

  4. The specific association of ZBTB7A (show ZBTB7A Proteins) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (show ZBTB7A Proteins) and the RUNX1/RUNX1T1 (show RUNX1T1 Proteins) fusion protein has been reported.

  5. miR (show MLXIP Proteins)-216a-3p can promote gastric cancer cell proliferation, migration, and invasion via targeting RUNX1 and activating the NF-kappaB (show NFKB1 Proteins) signaling pathway

  6. the t(5;21)(p15 (show CDKN2B Proteins);q22) translocation could be identified only when what had seemed like a del(21)(qq) in G-banded preparations was examined using FISH and RNA-sequencing directed at finding out what lay behind the 21q-.

  7. Our findings show the profound impact of RUNX1 allele dosage on gene expression profile and glucocorticoid sensitivity in AML, thereby opening opportunities for preclinical testing which may lead to drug repurposing and improved disease characterization.

  8. This study established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34 (show CD34 Proteins)+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated.

  9. Genome-engineered hPSCs expressing ETV6 (show ETV6 Proteins)-RUNX1 from the endogenous ETV6 (show ETV6 Proteins) locus show expansion of the CD19 (show CD19 Proteins)(-)IL-7R(+) compartment

  10. our study demonstrated that specific bone marrow abnormalities and acquired genetic alterations may be harbingers of progression to hematological malignancies in patients with familial platelet disorder with germline RUNX1 mutation.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Proteins) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Proteins) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 (show RUNX3 Proteins) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Proteins) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (runx1)
  • runt related transcription factor 1 L homeolog (runx1.L)
  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 protein
  • aml protein
  • aml-1 protein
  • Aml1 protein
  • aml1-evi-1 protein
  • amlcr1 protein
  • cbfa2 protein
  • evi-1 protein
  • Pebp2a2 protein
  • pebp2ab protein
  • Pebpa2b protein
  • Runx-1 protein
  • runx1 protein
  • runxa protein
  • XAML protein
  • Xaml1 protein

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Selected quality suppliers for RUNX1 Proteins (RUNX1)
Did you look for something else?