SH3-Domain Binding Protein 5 (BTK-Associated) Proteins (SH3BP5)

Human SH3-Domain Binding Protein 5 (BTK-Associated) (SH3BP5) interaction partners

1. SH3BP5, LMO3 (show LMO3 Proteins), and SNAP25 (show SNAP25 Proteins) were expressed in diffuse large B-cell lymphoma cells and associated with clinical features.

2. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11.

3. The interplay of p-JNK (show MAPK8 Proteins) with mitochondrial Sab leads to impaired respiration, ROS (show ROS1 Proteins) production, sustained JNK (show MAPK8 Proteins) activation, and apoptosis.

4. SH3BP5 binds to JNK (show MAPK8 Proteins) and directly inhibits JNK (show MAPK8 Proteins) through its two putative mitogen-activated protein kinase (show MAPK1 Proteins) interaction motifs (KIMs).

5. mitochondrial protein (show COX6B2 Proteins) Sab is phosphorylated by stress-activated protein kinase 3 (show MAPK12 Proteins)

Mouse (Murine) SH3-Domain Binding Protein 5 (BTK-Associated) (SH3BP5) interaction partners

1. The binding to and phosphorylation of Sab by p-JNK (show MAPK8 Proteins) on the outer mitochondrial membrane leads to SHP1 (show PTPN6 Proteins)-dependent and DOK4 (show DOK4 Proteins)-dependent inactivation of p-Src (show SRC Proteins) on the inner membrane; inactivation of mitochondrial Src (show SRC Proteins) inhibits electron transport and increases reactive oxygen species release, which sustains JNK (show MAPK8 Proteins) activation and promotes cell death and organ injury.

2. The interplay of p-JNK (show MAPK8 Proteins) with mitochondrial Sab leads to impaired respiration, ROS (show ROS1 Proteins) production, sustained JNK (show MAPK8 Proteins) activation, and apoptosis.

3. ER stress triggers an interaction of JNK (show MAPK8 Proteins) with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.

4. SH3BP5 binds to JNK (show MAPK8 Proteins) and directly inhibits JNK (show MAPK8 Proteins) through its two putative mitogen-activated protein kinase (show MAPK1 Proteins) interaction motifs (KIMs).

5. JNK (show MAPK8 Proteins)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF (show TNF Proteins)) requires mitochondrial Sab protein expression in mice