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The protein encoded by SMARCD2 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Additionally we are shipping SMARCD2 Proteins (4) and many more products for this protein.
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Data show that both CEBPE (show CEBPE Antibodies) and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD (show SGCD Antibodies)) abolish the interaction with SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) and secondary granule gene expression, thus providing a molecular basis for this disease.
Defective expression of SMARCD2 (SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies)-related, matrix-associated (show SMARCA5 Antibodies), actin-dependent regulator of chromatin, subfamily D (show CYP Antibodies), member 2) leads to transcriptional and chromatin changes in acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) promyelocytic cells, suggesting SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.
the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated.
the Rac (show AKT1 Antibodies)- and Unkempt-dependent process leading to BAF60b ubiquitination takes place in the nuclear compartment
Baf60b, a member of the SWI/SNF chromatin remodeling complex (show SMARCA2 Antibodies), links chromatin opening to ATM (show ATM Antibodies) activation by facilitating ATM (show ATM Antibodies) recruitment to the open chromatin regions of a panel of hepatic gene loci.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2
, 60 kDa BRG-1/Brm-associated factor subunit B
, BRG1-associated factor 60B
, SWI/SNF complex 60 kDa subunit B
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
, Swp73-like protein
, chromatin remodeling complex BAF60B subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60B