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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (128) and Sclerostin Proteins (18) and many more products for this protein.
Showing 10 out of 63 products:
Human Sclerostin ELISA Kit for Sandwich ELISA - ABIN457071
Cidem, Usta, Karacan, Kucuk, Uludag, Gun: Effects of sex steroids on serum sclerostin levels during the menstrual cycle. in Gynecologic and obstetric investigation 2013
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Human Sclerostin ELISA Kit for Sandwich ELISA - ABIN415155
Brabnikova Maresova, Pavelka, Stepan: Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes. in Calcified tissue international 2013
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Mouse (Murine) Sclerostin ELISA Kit for Sandwich ELISA - ABIN426039
Yorgan, Peters, Jeschke, Benisch, Jakob, Amling, Schinke: The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015
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Rat (Rattus) Sclerostin ELISA Kit for Sandwich ELISA - ABIN416496
Kim, Lee, Jo, Song, Lim, Park, Bonewald, Kim: Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. in Life sciences 2013
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Rat (Rattus) Sclerostin ELISA Kit for Sandwich ELISA - ABIN585201
Ferreira, Ferrari, Neves, Cavallari, Dominguez, Dos Reis, Graciolli, Oliveira, Liu, Sabbagh, Jorgetti, Schiavi, Moysés: Effects of dietary phosphate on adynamic bone disease in rats with chronic kidney disease--role of sclerostin? in PLoS ONE 2013
Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%
serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness
The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.
SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway
No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.
Positivity of RANKL (show TNFSF11 ELISA Kits) and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (show TNFSF11 ELISA Kits) or SOST was associated with increased concentrations of the factors.
Osterix (show SP7 ELISA Kits) and RUNX2 (show RUNX2 ELISA Kits) are transcriptional regulators of sclerostin in human bone
Sclerostin But Not Dickkopf-1 (show DKK1 ELISA Kits) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (show COL1A2 ELISA Kits).
High serum levels of sclerostin and Dkk-1 (show DKK1 ELISA Kits) are associated with acute ischaemic stroke
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (show LYST ELISA Kits) adipogenesis, at least in part, through the Wnt (show WNT2 ELISA Kits)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (show GJA1 ELISA Kits)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (show TNFSF11 ELISA Kits) and SOST, leading to osteoclast inhibition and Wnt (show WNT2 ELISA Kits) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (show PFDN5 ELISA Kits).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.
In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.
These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (show WNT2 ELISA Kits) signaling pathway inhibition.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.