anti-Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) Antibodies

SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Proteins (20) and SIGLEC5 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC5 8778 O15389
SIGLEC5 292843  
SIGLEC5    
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Top anti-SIGLEC5 Antibodies at antibodies-online.com

Showing 10 out of 178 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated CyTOF, ELISA (Capture), FACS, Neut Cell Adhesion Mediated by Siglec-5 and Neutralization by Human Siglec-5/14 Antibody. Recombinant Human Siglec-5 Fc Chimera. The ND50 is typically 0.04-0.2 ug/mL. Detection of Siglec-5/14 in Human Monocytes by Flow Cytometry. Human blood derived monocytes were stained with Mouse Anti-Human Siglec-5/14 Monoclonal Antibody. 500 μg Log in to see 8 to 9 Days
$392.11
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CD170 / SIGLEC5 Antibody  in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD170 expression in L929 (A), mouse lung (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated CyTOF, FACS, IHC, Neut, WB Cell Adhesion Mediated by Siglec-5 and Neutralization by Human Siglec-5/14 Antibody. Recombinant Human Siglec-5 Fc Chimera. The ND50 is typically 0.5-2.0 ug/mL. Detection of Siglec-5/14 in Human Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Human Siglec-5/14 Antigen Affinity-purified Polyclonal Antibody. 100 μg Log in to see 8 to 9 Days
$441.83
Details
Human Goat Biotin FACS, WB Detection of Siglec-5 and Siglec-14 in Human Monocytes and Granulocytes by Flow Cytometry. Human whole blood monocytes and granulocytes were stained with Human Siglec-5/14 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8 to 9 Days
$447.48
Details
Human Rabbit Un-conjugated WB SIGLEC5 Antibody (N-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SIGLEC5 antibody detected the SIGLEC5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Antibody is used in Western blot to detect Siglec5 in mouse liver tissue lysate. Western blot analysis in SK-BR-3 cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of HL60 and K562 cell lines, using SIGLEC5 antibody. 100 μL Log in to see 11 to 13 Days
$433.51
Details

Top referenced anti-SIGLEC5 Antibodies

  1. Human Monoclonal SIGLEC5 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899350 : Gunnarsson, Fornander, Påhlsson, Grenegård: Sialic acid residues play a pivotal role in alpha(1)-acid glycoprotein (AGP)-induced generation of reactive oxygen species in chemotactic peptide pre-activated neutrophil granulocytes. in Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2010 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SIGLEC5 Primary Antibody for FACS, WB - ABIN4899349 : Zou, Chastain, Moir, Ford, Trandem, Martinelli, Cicala, Crocker, Arthos, Sun: Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. in PLoS ONE 2011 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SIGLEC5 Primary Antibody for CyTOF, FACS - ABIN4899306 : Costelloe, Watson, Murphy, McQuillan, Loscher, Armstrong, Garlanda, Mantovani, ONeill, Mills, Lynch: IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. in Journal of neurochemistry 2008 (PubMed)
    Show all 3 Pubmed References

  4. Mouse (Murine) Monoclonal SIGLEC5 Primary Antibody for IHC (fro), FACS - ABIN2689902 : Angata, Hingorani, Varki, Varki: Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal SIGLEC5 Primary Antibody for IHC (p), ELISA - ABIN544592 : Patel, Brinkman-Van der Linden, Altmann, Gish, Balasubramanian, Timans, Peterson, Bell, Bazan, Varki, Kastelein: OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal SIGLEC5 Primary Antibody for ELISA, WB - ABIN544593 : Cornish, Freeman, Forbes, Ni, Zhang, Cepeda, Gentz, Augustus, Carter, Crocker: Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. in Blood 1998 (PubMed)
    Show all 3 Pubmed References

More Antibodies against SIGLEC5 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5) interaction partners

  1. PSGL1 and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1-mediated leukocyte rolling and the inflammatory response in general.

  2. An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.

  3. Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.

  4. we found that secretory IgA is taken up by M cells via the Dectin-1 receptor, with the possible involvement of Siglec-5 acting as a co-receptor.

  5. These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.

  6. Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.

  7. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein.

  8. Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.

  9. expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.

  10. Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.

  11. Siglecs-5 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid.

  12. The expression levels of Siglec-5 were high or detectable in bone marrow plasma from AML patients and serum from normal donors.

  13. Siglec-14 and Siglec-5 appear to be the first glycan binding paired receptors. Near-complete sequence identity of the amino-terminal part of human Siglec-14 and Siglec-5 indicates partial gene conversion between SIGLEC14 and SIGLEC5.

  14. Siglec-5 is identified as a receptor for alpha-1-acid glycoprotein (AGP) 1 in human neutrophils.

  15. Structural implications of SIGLEC5-mediated sialoglycan recognition are reported.

  16. Group B Streptococcus beta protein binding to Siglec-5 functions to impair leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival.

SIGLEC5 Antigen Profile

Protein Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Gene names and symbols associated with SIGLEC5

  • sialic acid binding Ig like lectin 5 (SIGLEC5) antibody
  • sialic acid-binding Ig-like lectin 5 (LOC100597560) antibody
  • sialic acid binding Ig-like lectin 5 (Siglec5) antibody
  • CD33L2 antibody
  • CD170 antibody
  • OB-BP2 antibody
  • OBBP2 antibody
  • SIGLEC-5 antibody

Protein level used designations for SIGLEC5

CD33 antigen-like 2 , OB-binding protein 2 , obesity-binding protein 2 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding immunoglobulin-like lectin 5 , sialic acid binding Ig-like lectin 5

GENE ID SPECIES
8778 Homo sapiens
100597560 Nomascus leucogenys
292843 Rattus norvegicus
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