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SIGLEC5 encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Additionally we are shipping SIGLEC5 Antibodies (174) and SIGLEC5 Proteins (20) and many more products for this protein.
Showing 2 out of 8 products:
Human SIGLEC5 ELISA Kit for Sandwich ELISA - ABIN625088
Wu, Ding, Han, Arriens, Wei, Han, Pedroza, Jiang, Anolik, Petri, Sanz, Saxena, Mohan: Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study. in Journal of proteome research 2016
PSGL1 (show SELPLG ELISA Kits) and Siglec-5 are in close proximity at the leukocyte surface.SPSGL1 is a ligand for Siglec-5 and interacts with Siglec-5 ectodomain.Siglec-5 plays a role in PSGL1 (show SELPLG ELISA Kits)-mediated leukocyte rolling and the inflammatory response in general.
An unbiased screen revealed Hsp70 as a ligand for Siglec-5 and Siglec-14. Hsp70 stimulation through Siglec-5 delivers an anti-inflammatory signal, while stimulation through Siglec-14 is pro-inflammatory.
Data indicate that the Siglec-5/14 genotype influences neutrophil responses to group B Streptococcus.
we found that secretory IgA (show IgA ELISA Kits) is taken up by M cells via the Dectin-1 (show CLEC7A ELISA Kits) receptor, with the possible involvement of Siglec-5 acting as a co-receptor.
These studies demonstrate the Siglec5 carbohydrate recognition domain alone is sufficient for binding sialylated carbohydrates and provide a foundation for further investigation of Siglec5 structure and function.
Siglec-5 expression protects T cells from HIV-1- and apoptosis-induced cell death and contributes to the different outcomes of HIV-1 infection in humans and chimpanzees.
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA (show IgA ELISA Kits)) have separate binding sites in streptococcal beta protein.
Siglec-5 expression correlates with lack of proliferation in a subset of human cells, and is upregulated by activation of chimpanzee but not human lymphocytes.
expression of Siglec-5 on cells of the myelomonocytic lineage and alteration of its expression by inflammatory stimuli suggest a role for this protein in cell/cell interactions following microbial exposure.
Siglec-5 can be classified as an inhibitory receptor with the potential to mediate SHP-1 and/or SHP-2-dependent signaling in the absence of tyrosine phosphorylation.
The Siglec-E-deficient dendritic cells were defective for TRIF-mediated IFN-beta (show IFNB1 ELISA Kits) production in response to E. coli infection.
This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (show SIGLEC1 ELISA Kits).
new data relating to the structure and function of Siglec-E, the major CD33 (show CD33 ELISA Kits)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.
indicate that Siglec-9 (show SIGLEC9 ELISA Kits) affects several different signaling pathways in IL-4 (show IL4 ELISA Kits)-stimulated macrophages, which resulted in enhanced induction of Arg1 (show ARG1 ELISA Kits) in Siglec-9 (show SIGLEC9 ELISA Kits)-expressing RAW264 cells
Competitive ELISA assays confirmed the involvement of sulfated (show SULF1 ELISA Kits) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment
Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits)) interaction and endotoxemia.
Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (show CD33 ELISA Kits)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.
siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (show NOX1 ELISA Kits) activation and ROS (show ROS1 ELISA Kits) production
These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (show MUC1 ELISA Kits)-expressing tumor in the transgenic mice.
Siglec-9 (show SIGLEC9 ELISA Kits) expressed on immune cells may play a role as a potential counterreceptor for MUC1 (show MUC1 ELISA Kits) and that this signaling may be another MUC1 (show MUC1 ELISA Kits)-mediated pathway and function in parallel with a growth factor-dependent pathway.
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
CD33 antigen-like 2
, OB-binding protein 2
, obesity-binding protein 2
, sialic acid-binding Ig-like lectin 5
, sialic acid-binding immunoglobulin-like lectin 5
, SIGLEC-like 1
, myeloid inhibitory siglec
, sialic acid binding Ig-like lectin 5
, sialic acid-binding Ig-like lectin 12
, sialic acid-binding Ig-like lectin E
, sialic acid-binding Ig-like lectin-like 1
, sialic acid-binding immunoglobulin-like lectin E