Sialic Acid Binding Ig-Like Lectin 8 Proteins (SIGLEC8)

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Antibodies (65) and SIGLEC8 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGLEC8 27181 Q9NYZ4
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Top SIGLEC8 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Human His tag 100 μg 13 to 16 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human Un-conjugated   10 μg 11 to 12 Days
HEK-293 Cells Human His tag   1 mg 5 Days

SIGLEC8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced SIGLEC8 Proteins

  1. Human SIGLEC8 Protein expressed in Wheat germ - ABIN1320000 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007 (PubMed)

More Proteins for Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners

  1. These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases

  2. Targeting saporin to Siglec-8 consistently caused extensive cell death.

  3. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2.

  4. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  5. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  6. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  7. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  8. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping

  9. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  10. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis.

  11. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.

  12. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  13. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells

  14. The Siglec-8 gene may be a susceptibility locus for asthma.

  15. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis

  16. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  17. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage.

  18. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.

  19. First reported inhibitory effects of Siglec engagement on human mast cells.

  20. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils.

SIGLEC8 Protein Profile

Protein Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Gene names and symbols associated with SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8)
  • sialic acid-binding Ig-like lectin 8 (LOC506364)
  • SAF2 protein
  • SIGLEC-8 protein
  • SIGLEC8 protein
  • SIGLEC8L protein

Protein level used designations for SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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