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STAP2 encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. Additionally we are shipping Signal Transducing Adaptor Family Member 2 Antibodies (97) and many more products for this protein.
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High STAP2 expression is associated with prostate cancer.
The Pyk2 (show PTK2B Proteins)/STAP-2 interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis.
STAP2 is upregulated in uterosacral ligaments in pelvic organ prolapse
Our results demonstrate a critical contribution of STAP-2 in BCR-ABL (show ABL1 Proteins) activity.
STAP-2 is a novel participant in the regulation of T cell apoptosis after stimulation
Interactions of STAP-2 with Brk (show PTK6 Proteins) and STAT3 (show STAT3 Proteins) participate in cell growth of human breast cancer cells.
STAP-2 expression in Jurkat T cells affects migration following stromal cell-derived factor-1alpha (SDF-1alpha) treatment; STAP-2 association with Vav1, the guanine-nucleotide exchanging factor for Rac1, enhances downstream Vav1/Rac1 signaling.
These data indicate that STAP-2/BKS negatively controls the FcepsilonRI (show FCER1G Proteins)-mediated calcium mobilization and degranulation by direct modulation of tyrosine phosphorylation of PLC (show HSPG2 Proteins)-gamma.
STAP-2/BKS is a modulator of STAT5 (show STAT5A Proteins)-mediated signaling
STAP-2 associates with FAK (show PTK2 Proteins) and enhances its degradation, proteasome inhibitors block FAK (show PTK2 Proteins) degradation, and STAP-2 recruits an endogenous E3 ubiquitin ligase (show MUL1 Proteins), Cbl (show CBL Proteins), to FAK (show PTK2 Proteins).
results demonstrate a contribution of CCR7 (show CCR7 Proteins) to STAP-2-dependent enhancement of BCR-ABL (show ABL1 Proteins)-mediated cell growth in Ba/F3 cells
signal transducing adaptor protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression and tumorigenesis in B16F10 melanoma cells
STAP-2 has a potential to regulate plural molecular events during pathological inflammatory responses.
Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses.
STAP-2 directly binds to c-Fms (show CSF1R Proteins) and interferes with the PI3K signaling, which leads to macrophage motility, in Raw 264.7 cells
These results suggest that STAP-2 acts as an endogenous negative regulator of Epstein-Barr virus LMP1 (show PDLIM7 Proteins)-mediated signaling through TRAF3 (show TRAF3 Proteins) and TRADD (show TRADD Proteins).
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.
signal-transducing adaptor protein 2
, BRK substrate
, breast tumor kinase substrate
, brk kinase substrate
, signal-transducing adaptor protein-2