Signal-Regulatory Protein alpha Proteins (SIRPA)

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. Additionally we are shipping SIRPA Antibodies (217) and SIRPA Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRPA 140885 P78324
SIRPA 19261 P97797
SIRPA 25528 P97710
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Top SIRPA Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 100 μg Log in to see 14 to 16 Days
$382.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human His tag Human recombinant CD172A / SIRP. The purity of rh CD 172a/SIRPA was determined by DTT-reduced (+) SDSPAGE and staining overnight with Coomasste Blue. 50 μg Log in to see 2 to 3 Days
$615.00
Details
Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$512.00
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Baculovirus infected Insect Cells Rat His tag 50 μg Log in to see 13 to 16 Days
$400.00
Details

SIRPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Mouse (Murine) , ,
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Rat (Rattus) , , ,
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More Proteins for Signal-Regulatory Protein alpha (SIRPA) Interaction Partners

Human Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. SIRP alpha protein is under-expressed in low and high-grades of astrocytoma from patients' brain samples.

  2. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  3. SIRPalpha might play an important role in the progression of oral leukoplakia and oral cancer, and could be a pivotal therapeutic target in oral squamous cell carcinoma, regulating the phenotype of macrophages via targeting NF-kappaB (show NFKB1 Proteins) signaling.

  4. TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47 (show CD47 Proteins)-SIRPalpha axis by binding to human CD47 (show CD47 Proteins) and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.

  5. data suggest that TTI-621 may be efficacious in triggering the destruction of cancer cells by a diverse population of TAMs found in vivo and support possible combination approaches to augment the activity of CD47 (show CD47 Proteins) blockade

  6. CD47 (show CD47 Proteins), TSP1 (show THBS1 Proteins), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.

  7. exploited by Hepatitis E virus to negative regulated IFN-beta (show IFNB1 Proteins) of the host innate immune system to promote viral infection

  8. Data suggest a reduction in the CD47 antigen (show CD47 Proteins)/signal-regulatory protein alpha (SIRPalpha) pathway by programmed cell death protein 1 (PD-1 (show PDCD1 Proteins)) blockade, which regulates Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs).

  9. agents that block the CD47 (show CD47 Proteins):SIRP-alpha engagement are attractive therapeutic targets as a monotherapy or in combination with additional immune-modulating agents for activating antitumor T cells in vivo

  10. the data suggest that combinatorial actions of ADAM10 (show ADAM10 Proteins) and gamma-secretase on SIRPalpha cleavage promote inflammatory signaling.

Mouse (Murine) Signal-Regulatory Protein alpha (SIRPA) interaction partners

  1. Anti-SIRPA antibody immunotherapy enhances neutrophil and macrophage antitumor activity.

  2. SIRPalpha-expressing dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF (show TNF Proteins) receptor ligands in the adult mouse spleen.

  3. CCR7 (show CCR7 Proteins) deficiency results in apoptosis of Sirpa- dendritic cells, which is counterbalanced by expansion of immature Sirpa+ dendritic cells that efficiently induce Treg generation.

  4. Mechanistic studies suggest a PKC-Syk (show SYK Proteins)-mediated signaling pathway, to which IL-10 (show IL10 Proteins) conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin (show CALR Proteins) Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47 (show CD47 Proteins)(-/-) or Sirpalpha(-/-) mice.

  5. these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47 (show CD47 Proteins)-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity

  6. Data provide evidence that SIRPalpha-mediated phagocytosis is not a major determinant in prion (show PRNP Proteins) disease pathogenesis.

  7. Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47 (show CD47 Proteins)-SIRPA interaction and Rac1/Akt (show AKT1 Proteins) activation.

  8. In conclusion, our data suggest that SIRPalpha signaling through SHP-2 (show PTPN11 Proteins)-PI3K-Akt2 (show AKT2 Proteins) strongly influences osteoblast differentiation from bone marrow stromal cells.

  9. These results indicate an important role for CD47 (show CD47 Proteins)-SIRPalpha interactions in innate control of malaria and suggest novel targets for intervention.

  10. TLR5 (show TLR5 Proteins) mediates CD172a(+) intestinal lamina propria dendritic cell induction of Th17 cells.

SIRPA Protein Profile

Protein Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene names and symbols associated with SIRPA

  • signal regulatory protein alpha (SIRPA)
  • signal-regulatory protein alpha (SIRPA)
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC458039)
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100400378)
  • tyrosine-protein phosphatase non-receptor type substrate 1 (LOC100590224)
  • signal-regulatory protein alpha (Sirpa)
  • AI835480 protein
  • Bit protein
  • CD172a protein
  • MFR protein
  • MYD-1 protein
  • P84 protein
  • Ptpns1 protein
  • SHP-1 protein
  • SHPS-1 protein
  • SHPS1 protein
  • SIRP protein
  • SIRP-A1 protein
  • SIRP-B1 protein
  • SIRPA protein
  • swc3 protein

Protein level used designations for SIRPA

CD172 antigen-like family member A , brain-immunoglobulin-like molecule with tyrosine-based activation motifs , inhibitory receptor SHPS-1 , macrophage fusion receptor , myd-1 antigen , tyrosine phosphatase SHP substrate 1 , tyrosine-protein phosphatase non-receptor type substrate 1 , MyD-1 antigen , SHP substrate 1 , SHPS-1 , protein tyrosine phosphatase, non-receptor type substrate 1 , signal-regulatory protein alpha-1 , sirp-alpha-1 , signal-regulatory protein alpha , signal regulatory protein alpha , tyrosine-protein phosphatase non-receptor type substrate 1-like , brain Ig-like molecule with tyrosine-based activation motifs , brain immunological-like with tyrosine-based motifs , mSIRP-alpha1 , myD-1 antigen , Brain immunoglobulin like protein with tyrosine - based activation motifs , Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1) , Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) , macrophage membrane protein MFP150 , swine workshop cluster 3 antigen

GENE ID SPECIES
140885 Homo sapiens
327666 Bos taurus
419267 Gallus gallus
458039 Pan troglodytes
609452 Canis lupus familiaris
717811 Macaca mulatta
100067339 Equus caballus
100351485 Oryctolagus cuniculus
100400378 Callithrix jacchus
100456232 Pongo abelii
100590224 Nomascus leucogenys
19261 Mus musculus
25528 Rattus norvegicus
494566 Sus scrofa
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