Sirtuin 2 Proteins (SIRT2)

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Antibodies (127) and Sirtuin 2 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top Sirtuin 2 Proteins at

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Human His tag 10 μg Log in to see 15 to 19 Days
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days

SIRT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
Rat (Rattus) ,

More Proteins for Sirtuin 2 (SIRT2) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) interaction partners

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) interaction partners

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Proteins) expression.

Human Sirtuin 2 (SIRT2) interaction partners

  1. The SIRT2 functions as a mitochondrial sirtuin (show SIRT1 Proteins), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.

  2. increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence

  3. SIRT2 and RIPK1 (show RIPK1 Proteins) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (show RIPK1 Proteins) in the cytotrophoblast cytoplasm.

  4. mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (show SIRT1 Proteins) domain, thereby increasing the catalytic efficiency of the mutant enzymes.

  5. targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.

  6. BEX4 (show BEX4 Proteins) overexpression causes an imbalance between TUB (show TUB Proteins) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.

  7. SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2 (show NFE2 Proteins)-related factor 2 (NRF2 (show GABPA Proteins)) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 (show GABPA Proteins) levels.

  8. Identify the miR (show MLXIP Proteins)-200c-SIRT2 axis as a key regulator of metabolic reprogramming (Warburg-like effect), via regulation of glycolytic enzymes, during human induced pluripotency and pluripotent stem cell function.

  9. Four novel heterozygous DNA sequence variants and five SNPs of sirt2 protein were found in both acute myocardial infarction patients and control with similar frequencies.

  10. These results indicate overlapping and distinct functions of HDAC6 (show HDAC6 Proteins) and SIRT2.

Cow (Bovine) Sirtuin 2 (SIRT2) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Proteins)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) interaction partners

  1. AMPK (show PRKAA1 Proteins) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.

  2. SIRT2 promotes AMPK (show PRKAA1 Proteins) activation by deacetylating the kinase LKB1 (show STK11 Proteins). Loss of SIRT2 reduces AMPK (show PRKAA1 Proteins) activation, promotes aging-related and Ang II (show AGT Proteins)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.

  3. found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7 (show AK7 Proteins)

  4. mitochondrial dysfunction triggers LKB1 (show STK11 Proteins)-mediated AMPK (show PRKAA1 Proteins) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.

  5. SIRT-2 regulates microvascular inflammation in obese mice with sepsis.

  6. Loss of SIRT2 expression is associated with breast Cancer.

  7. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  8. QKI (show QKI Proteins) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.

  9. Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.

  10. Results suggest a role for Hdac5 (show HDAC5 Proteins) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

Sirtuin 2 (SIRT2) Protein Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Gene names and symbols associated with Sirtuin 2 Proteins (SIRT2)

  • Sirtuin 2 (Sirt2)
  • sirtuin 2 (SIRT2)
  • sirtuin 2 S homeolog (sirt2.S)
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2)
  • sirtuin 2 (SRT2)
  • sirtuin 2 (sirt2)
  • sirtuin 2 (Sirt2)
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2)
  • 5730427M03Rik protein
  • AtSRT2 protein
  • BmSirt2 protein
  • CG5085 protein
  • D.mel2 protein
  • Dmel\\CG5085 protein
  • dSIRT2 protein
  • SIR2 protein
  • Sir2l protein
  • SIR2L2 protein
  • Sirt2 protein
  • sirtuin 2 protein
  • T2K12.8 protein
  • wu:fb57d05 protein
  • zgc:55966 protein
  • zgc:77003 protein

Protein level used designations for Sirtuin 2 Proteins (SIRT2)

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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