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SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Antibodies (127) and Sirtuin 2 Kits (29) and many more products for this protein.
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Sirt2 has an role in the regulation of mitochondrial energy metabolism.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Proteins) expression.
The SIRT2 functions as a mitochondrial sirtuin (show SIRT1 Proteins), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.
increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence
SIRT2 and RIPK1 (show RIPK1 Proteins) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (show RIPK1 Proteins) in the cytotrophoblast cytoplasm.
mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (show SIRT1 Proteins) domain, thereby increasing the catalytic efficiency of the mutant enzymes.
targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.
BEX4 (show BEX4 Proteins) overexpression causes an imbalance between TUB (show TUB Proteins) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.
SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2 (show NFE2 Proteins)-related factor 2 (NRF2 (show GABPA Proteins)) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 (show GABPA Proteins) levels.
Identify the miR (show MLXIP Proteins)-200c-SIRT2 axis as a key regulator of metabolic reprogramming (Warburg-like effect), via regulation of glycolytic enzymes, during human induced pluripotency and pluripotent stem cell function.
Four novel heterozygous DNA sequence variants and five SNPs of sirt2 protein were found in both acute myocardial infarction patients and control with similar frequencies.
These results indicate overlapping and distinct functions of HDAC6 (show HDAC6 Proteins) and SIRT2.
The results indicate that the variations in the class I sirtuin (show SIRT1 Proteins) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Proteins)-) diplotypes performed better than other combinations.
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
AMPK (show PRKAA1 Proteins) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.
SIRT2 promotes AMPK (show PRKAA1 Proteins) activation by deacetylating the kinase LKB1 (show STK11 Proteins). Loss of SIRT2 reduces AMPK (show PRKAA1 Proteins) activation, promotes aging-related and Ang II (show AGT Proteins)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.
found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7 (show AK7 Proteins)
mitochondrial dysfunction triggers LKB1 (show STK11 Proteins)-mediated AMPK (show PRKAA1 Proteins) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (show FRAP1 Proteins)-RAPTOR (show RPTOR Proteins) and Glut1 (show SLC2A1 Proteins)-mediated glucose uptake.
SIRT-2 regulates microvascular inflammation in obese mice with sepsis.
Loss of SIRT2 expression is associated with breast Cancer.
Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.
QKI (show QKI Proteins) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.
Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.
Results suggest a role for Hdac5 (show HDAC5 Proteins) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
, sirtuin 2
, NAD-dependent deacetylase SIRT2
, NAD-dependent deacetylase sirtuin-2
, histone NADC
, silent information regulator 2
, nicotinamide adenine dinucleotide-dependent histone deacetylase
, NAD-dependent deacetylase sirtuin 2 homolog
, NAD-dependent protein deacetylase sirtuin-2
, SIR2-like protein 2
, regulatory protein SIR2 homolog 2
, sir2-related protein type 2
, sirtuin type 2
, sirtuin-like protein 2
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
, 5E5 antigen