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SIRT2 Products

(Sirtuin 2 (SIRT2))

Categories

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010].

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Featured SIRT2 Categories

SIRT2 Antibodies

High quality antibodies with extensive validation data.

SIRT2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SIRT2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIRT2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC (p), WB
Validations
  • (6)
Cat. No. ABIN3043924
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, RNAi, ELISA, WB
Validations
  • (5)
Cat. No. ABIN564966
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application EIA, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN615066
Quantity 50 μg
Datasheet Datasheet

Recommended SIRT2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959488
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959490
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959489
Quantity 96 tests
Datasheet Datasheet

Recommended SIRT2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095570
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136726
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320041
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SIRT2 products

Guiraud, Edwards, Squire, Babbs, Shah, Berg, Chen, Davies: "Identification of serum protein biomarkers for utrophin based DMD therapy." in: Scientific reports, Vol. 7, pp. 43697, (2018) (PubMed).

Keskin-Aktan, Akbulut, Yazici-Mutlu, Sonugur, Ocal, Akbulut: "The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats." in: Brain research bulletin, Vol. 137, pp. 306-310, (2018) (PubMed).

Ito, Shimazu, Maeda, Shah, Tsunoda, Iemura, Natsume, Suzuki, Motohashi, Yamamoto, Yoshida: "The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1." in: Science signaling, Vol. 8, Issue 404, pp. ra120, (2016) (PubMed).

Bajpe, Prahallad, Horlings, Nagtegaal, Beijersbergen, Bernards: "A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity." in: Oncogene, Vol. 34, Issue 4, pp. 531-6, (2015) (PubMed).

Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: "NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells." in: The Journal of clinical investigation, (2014) (PubMed).

Benavente, Schnell, Jacobson: "Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin." in: PLoS ONE, Vol. 7, Issue 7, pp. e42276, (2012) (PubMed).

Shepard, Joseph, Kannarkat, Rutledge, Tuma, Tuma: "Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function." in: Hepatology (Baltimore, Md.), Vol. 48, Issue 5, pp. 1671-9, (2008) (PubMed).

Zhang, Xie, Xue, Gu: "Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats." in: Journal of Asian natural products research, Vol. 10, Issue 7-8, pp. 807-12, (2008) (PubMed).

Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: "The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility." in: The Journal of cell biology, Vol. 180, Issue 5, pp. 915-29, (2008) (PubMed).

Inoue, Hiratsuka, Osaki, Oshimura: "The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation." in: Cell cycle (Georgetown, Tex.), Vol. 6, Issue 9, pp. 1011-8, (2007) (PubMed).

Synonyms and alternative names related to SIRT2

Sirtuin 2 (Sirt2), sirtuin 2 (SIRT2), sirtuin 2 S homeolog (sirt2.S), NAD-dependent deacetylase sirtuin 2 homolog (Sirt2), sirtuin 2 (SRT2), sirtuin 2 (sirt2), sirtuin 2 (Sirt2), sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2), 5730427M03Rik, AtSRT2, BmSirt2, CG5085, D.mel2, Dmel\\CG5085, dSIRT2, sir2, SIR2, SIR2L, Sir2l, SIR2L2, SIRT2, Sirt2, SIRTUIN 2, sirtuin 2, T2K12.8, wu:fb57d05, zgc:55966, zgc:77003

Protein level used designations for SIRT2

  • CG5085-PA
  • Sirt2-PA
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
  • sirtuin 2
  • NAD-dependent deacetylase SIRT2
  • NAD-dependent deacetylase sirtuin-2
  • histone NADC
  • silent information regulator 2
  • nicotinamide adenine dinucleotide-dependent histone deacetylase
  • NAD-dependent deacetylase sirtuin 2 homolog
  • NAD-dependent protein deacetylase sirtuin-2
  • SIR2-like protein 2
  • regulatory protein SIR2 homolog 2
  • sir2-related protein type 2
  • sirtuin type 2
  • sirtuin-like protein 2
  • mSIR2L2
  • silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
  • 5E5 antigen
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