anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) Antibodies

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN3 Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNN3 54263 P70605
KCNN3 3782 Q9UGI6
KCNN3 140493  
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Top anti-KCNN3 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNN3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Daudi cell lysate KCNN3 is supported by BioGPS gene expression data to be expressed in Daudi 100 μL Log in to see 2 to 3 Days
$319.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Prostate (formalin-fixed, paraffin-embedded) stained with KCNN3 antibody ABIN214788 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Skin (formalin-fixed, paraffin-embedded) stained with KCNN3 antibody ABIN214788 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain Tissue using KCNN3(SK3) Rabbit Polyclonal Antibody diluted at 1:200. 100 μL Log in to see Available
$181.73
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded Human gastric using KCNN3 antibody at dilution of 1:100 (x400 lens). 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using KCNN3 antibody (ABIN5973609) at 1/1000 dilution. 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Mouse Un-conjugated ELISA, WB KCNN3 polyclonal antibody (A01), Lot # 050921JC01 Western Blot analysis of KCNN3 expression in Y-79 . Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated WB KCNN3 antibody used at 2.5 ug/ml to detect target protein. 100 μg Log in to see 9 to 11 Days
$388.93
Details
Human Rabbit Un-conjugated WB KCNN3 antibody used at 2 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
$473.93
Details
Human Rabbit Un-conjugated IHC, WB   200 μL Log in to see 11 to 16 Days
$1,238.29
Details

Top referenced anti-KCNN3 Antibodies

  1. Human Polyclonal KCNN3 Primary Antibody for ELISA, WB - ABIN561588 : Coyle, ODonnell, Puri: Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease. in Journal of pediatric surgery 2015 (PubMed)

More Antibodies against KCNN3 Interaction Partners

Human Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) interaction partners

  1. SK3 expression was strongly reduced in the Hirschsprung disease patient intestines, both in the ganglionic and aganglionic bowel, compared to the control intestines.

  2. this is the first report to associate KCNN3 with poor prognosis and drug resistance in ovarian cancer (OC). The present findings indicated that KCNN3 is a potential prognostic marker and therapeutic target for OC.

  3. SK current is increased via the enhanced activation of CaMKII in patients with atrial fibrillation.

  4. Data indicate that the inhibition of the Store Operated Calcium Entry (SOCE)-dependent colon cancer cell migration through SK3/TRPC1/Orai1 channel complex by the alkyl-lipid Ohmline may be a strategy to modulate Anti-EGFR mAb action in metastatic colorectal cancer (mCRC).

  5. A splice variant SK3.2 was found in ventricular myocyte mitochondria and its mRNA expression was studied.

  6. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival

  7. Edelfosine is able to effectively inhibit migration and invasion of UC cells in vitro and in vivo in an SK3-dependent way, pointing towards a possible role for Edelfosine as an antiinvasive drug to effectively inhibit UC cell invasion and metastasis.

  8. KCNN3 gene encodes small conductance calcium-activated potassium (SK) channel 3

  9. Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction

  10. Decreased SK3 expression in ganglionic bowel may explain the basis of persistent bowel symptoms in some patients following a properly performed pull-through operation for Hirschsprung's disease.

  11. KCNN3 single-nucleotide polymorphism rs13376333 significantly increases the risk of Atrial Fibrillation.

  12. There was no significant difference in the genotype distributions or allele frequencies of the SNP rs1131820 between AF patients and controls.

  13. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.

  14. Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes.

  15. Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization.

  16. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.

  17. SK3 channel is activated in neuroblastoma cells by overexpression of human endogenous retrovirus W family envelope gene.

  18. Atrial miR-499 is significantly upregulated in AF, leading to SK3 downregulation and possibly contributing to the electrical remodeling in AF.

  19. study shows SK3 channels are localized in CD34(+) cells and not in smooth muscle cells and that expression of SK3 channels is higher in non-pregnant compared to pregnant myometrium; propose SK3 activators reduce myometrium contractility by modulating telocyte function; first report to provide evidence for possible role of SK3 channels in uterine telocytes

  20. Specific expression of hSK3 led to deficits in attention and sensory gating and heightened sensitivity to a psychomimetic drug

Pig (Porcine) Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) interaction partners

  1. SK channels (KCNN1 and KCNN3) provide a mechanism for sensing changes in intracellular Ca(2+) near the apical membrane, evoking hyperpolarization necessary for increasing the driving force for anion efflux following P2Y receptor activation [KCNN1].

Cow (Bovine) Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) interaction partners

  1. Small conductance family member KCNN3 channel subtypes are activated in response to basolateral ATP challenge, essential in driving chloride secretion and thus fluid formation in the oviduct.

Mouse (Murine) Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) interaction partners

  1. the present study shows that KCa2.3 channels are located in the apical plasma membrane of endothelial cells, and occasionally at inter-endothelial junctions of the corpus cavernosum. We found that down-regulation of these channels increases norepinephrine contraction in corpus cavernosum strips, and it seems associated with erectile dysfunction.

  2. Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability.

  3. These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism.

  4. Dynamic coupling between TRPV4 and Ca(2+)-activated SK1/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 in kidney collecting duct cells.

  5. SK3 signaling microdomain modulates endothelial Ca(2+) dynamics, vascular tone, and blood pressure. SK3 knockout mice are hypertensive.

  6. The data of this study implicated the family of KCNN genes in alcohol, nicotine, and drug addiction, and identify KCNN3 as a mediator of voluntary and excessive alcohol consumption

  7. ovariectomy leads to a reduction in endothelial SK3 channel activity thereby reducing the SK3 contribution to endothelium-dependent hyperpolarization vasorelaxation.

  8. Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.

  9. Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels

  10. SK3 channel modulates placental vascular development and fetal health by altering VEGF signaling.

  11. SK3 is functionally expressed in the distal nephron and collecting ducts where induction of TRPV4-mediated Ca2+ influx activates the channel.

  12. Reduced SK3 expression attenuates endometrial cell migration and is associated with unsuccessful pregnancy outcomes.

  13. SK3 channel contributes importantly towards atrial action potential repolarization.

  14. Overexpression of the SK3 channel causes an increased risk of sudden death associated with bradyarrhythmias and heart block, possibly due to atrioventricular nodal dysfunction.

  15. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats

  16. SK3-mediated [Ca(2+)]i elevation and membrane potential hyperpolarization in trophectoderm cells are important for blastocyst hatching.

  17. The results established that the SK3 channel contributes to both maternal and fetal outcomes during pregnancy.

  18. We found that the calcium-activated potassium channel SK3 and the G protein-activated potassium channel GIRK are part of an independent pathway for vomeronasal organ activation

  19. The results showed that SK3 channels undergo Ca2+-dependent cycling between the plasma membrane and intracellular organelles; disrupting Ca2+-dependent endothelial caveolae cycling abolishes SK3 channel trafficking.

  20. Findings indicate that Sp1 and Sp3 compete to regulate SK3 channel expression during pregnancy in response to stimulation by estrogen.

KCNN3 Antigen Profile

Protein Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNN3

  • potassium calcium-activated channel subfamily N member 3 (Kcnn3) antibody
  • potassium calcium-activated channel subfamily N member 3 (KCNN3) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3) antibody
  • hSK3 antibody
  • KCa2.3 antibody
  • SK3 antibody
  • SKCA3 antibody

Protein level used designations for KCNN3

SKCa 3 , SKCa3 , small conductance calcium-activated potassium channel protein 3 , small-conductance Ca2+-activated K+ channel 3 , SK3 , calcium activated potassium channel SK3 , small conductance calcium-activated potassium channel 3

GENE ID SPECIES
54263 Rattus norvegicus
3782 Homo sapiens
490441 Canis lupus familiaris
397045 Sus scrofa
534180 Bos taurus
140493 Mus musculus
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