anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) Antibodies

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Additionally we are shipping SNRNP70 Proteins (8) and SNRNP70 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SNRNP70 20637 Q62376
SNRNP70 361574  
SNRNP70 6625 P08621
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Top anti-SNRNP70 Antibodies at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SNRP70 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate SNRNP70 is supported by BioGPS gene expression data to be expressed in HepG2 WB Suggested Anti-SNRP70  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HepG2 cell lysate  SNRNP70 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SNRP70 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate SNRNP70 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using SNRNP70 antibody (ABIN5973598) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat liver using SNRNP70 antibody (ABIN5973598) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SNRP70 Antibody [NBP1-57487] - Antibody Titration: 1 ug/ml HEK293. Western Blot: SNRP70 Antibody [NBP1-57487] - Jurkat cell lysate, Antibody Titration: 0.2-1 ug/ml 100 μL Log in to see 8 to 11 Days
$488.73
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SNRNP70 antibody. Immunohistochemistry of paraffin-embedded rat liver using SNRNP70 antibody. 100 μL Log in to see 13 to 14 Days
$393.25
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, WB Western Blot: SNRP70 Antibody [NBP1-57455] - Sample Tissue: Human Hela Antibody Dilution: 1.0 ug/ml Western Blot: SNRP70 Antibody [NBP1-57455] - HepG2 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days
$488.73
Details
Human Rabbit Un-conjugated WB SNRNP70 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SNRNP70 antibody detected the SNRNP70 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using SNRNP70 antibody (ABIN1877092) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. 100 μL Log in to see 11 to 13 Days
$366.77
Details

Top referenced anti-SNRNP70 Antibodies

  1. Cow (Bovine) Polyclonal SNRNP70 Primary Antibody for IHC, WB - ABIN2778829 : Dieker, Cisterna, Monneaux, Decossas, van der Vlag, Biggiogera, Muller: Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K. in Cell death and differentiation 2008 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SNRNP70 Primary Antibody for IHC, IHC (p) - ABIN4891514 : Nakaya, Alexiou, Maragkakis, Chang, Mourelatos: FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns. in RNA (New York, N.Y.) 2013 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal SNRNP70 Primary Antibody for IHC, WB - ABIN2778715 : Zhang, Walker, Tamplin, Rossant, Stanford, Hughes: Zfp206 regulates ES cell gene expression and differentiation. in Nucleic acids research 2006 (PubMed)
    Show all 4 Pubmed References

More Antibodies against SNRNP70 Interaction Partners

Zebrafish Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. These findings provide evidence for a new role of a general small nuclear ribonucleoprotein particle protein, U1C, as a mediator of alternative splicing regulation.

Mouse (Murine) Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. This splice-switching class of molecules is the first to specifically correct the ELP1 exon 20 splicing defect. Our data provide proof of principle of ExSpeU1s-adeno-associated virus particles as a novel therapeutic strategy for FD.

Human Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) interaction partners

  1. These results indicate that the galectin-3-U1 snRNP-pre-mRNA ternary complex is a functional E complex and that U1 snRNP is required to assemble galectin-3 onto an active spliceosome

  2. The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution.

  3. The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism.

  4. data lead to a model that FUS functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP

  5. The selection of 5'-splice site nucleotides by U1 snRNP is achieved predominantly through basepairing with U1 snRNA whilst U1-C fine-tunes relative affinities of mismatched 5'-splice sites.

  6. methylation of snRNP70 by SETMAR regulates constitutive and/or alternative splicing

  7. U1-70K interacts with the SMN complex and is required for nuclear gem integrity.

  8. Data indicate that small nuclear ribonucleoprotein U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates.

  9. [review] The presence of antibodies against U1snRNP autoantigen is considered the serological hallmark of mixed connective tissue disease (MCTD), which is characterized by overlapping features between at least two systemic autoimmune diseases.

  10. These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of Alzheimer's disease

  11. inhibition of U1 snRNP also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.

  12. High expression of U1-70K and other U1 small nuclear ribonucleoproteins spliceosome proteins in Alzheimer's disease patients and those with mild cognitive impairment.

  13. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus.

  14. U1-snRNP activates the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in CD14+ human monocytes dependently of anti-U1-snRNP Abs, leading to interleukin (IL)-1beta production.

  15. data identify some fungal proteins as possible triggers of anti-U1-70 kDa autoimmunity via molecular mimicry.

  16. the hypo-phosphorylated RS domain of SRSF1 interacts with its own RRM, thus competing with U1-70K binding, whereas the hyper-phosphorylated RS domain permits the formation of a ternary complex containing ESE, an SR protein, and U1 snRNP

  17. Recruitment of RNAPII, U1-70K and ASF/SF2 protein to transcription sites is splicing independent.

  18. crucial association of B19-NS1 in development of autoimmunity by inducing apoptosis and specific cleavage of 70 kDa U1-snRNP

  19. U1-70k isoforms control subunit dynamics in the human spliceosomal U1 snRNP

SNRNP70 Antigen Profile

Protein Summary

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

Gene names and symbols associated with SNRNP70

  • small nuclear ribonucleoprotein, U1 70kDa subunit (snrnp70) antibody
  • small nuclear ribonucleoprotein U1 subunit 70 (SNRNP70) antibody
  • small nuclear ribonucleoprotein 70 (U1) (snrnp70) antibody
  • small nuclear ribonucleoprotein 70 (U1) (Snrnp70) antibody
  • small nuclear ribonucleoprotein U1 subunit 70 (Snrnp70) antibody
  • small nuclear ribonucleoprotein, U1 70kDa subunit L homeolog (snrnp70.L) antibody
  • 70kDa antibody
  • 2700022N21Rik antibody
  • 3200002N22Rik antibody
  • AI325098 antibody
  • R74807 antibody
  • RNPU1Z antibody
  • Rnulp70 antibody
  • RPU1 antibody
  • Snp1 antibody
  • Snrp70 antibody
  • Srnp70 antibody
  • U1-70 antibody
  • U1-70K antibody
  • U1AP antibody
  • U1RNP antibody
  • U170K antibody
  • wu:fc20b04 antibody
  • zgc:136450 antibody

Protein level used designations for SNRNP70

U1 small nuclear ribonucleoprotein 70 kDa , U1 snRNP 70 kDa , U1-70K , small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen) , small nuclear ribonucleoprotein 70kDa (U1) , U1 small nuclear ribonucleoprotein polypeptide A , U1 small ribonucleoprotein 70kd , small nuclear ribonucleoprotein 70kDa , U1 small nuclear ribonucleoprotein 70 kDa polypeptide A

GENE ID SPECIES
493488 Xenopus (Silurana) tropicalis
747202 Pan troglodytes
100595176 Nomascus leucogenys
445398 Danio rerio
20637 Mus musculus
361574 Rattus norvegicus
397946 Xenopus laevis
6625 Homo sapiens
484388 Canis lupus familiaris
535113 Bos taurus
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