Small Nuclear Ribonucleoprotein Polypeptide N Proteins (SNRPN)

The protein encoded by SNRPN is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. Additionally we are shipping SNRPN Antibodies (86) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNRPN 6638 P63162
SNRPN 20646 P63163
SNRPN 81781 P63164
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Top SNRPN Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$225.40
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,610.67
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,610.67
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Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$2,610.67
Details

SNRPN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) Interaction Partners

Human Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) interaction partners

  1. The first study reporting an association between variability in the SNRPN gene and the risk of being obese.

  2. we have confirmed that SNRPN methylation increases with age, which raises further questions regarding the role of SNRPN expression during the aging process.

  3. the cases with partial loss of methylation in KCNQ1OT1 and SNRPN present clinical features different to those associated with the corresponding imprinting syndromes

  4. Knockdown of SNRPN was demonstrated to significantly inhibit medulloblastoma cell growth and induce G2/M phase arrest in vitro.

  5. indicate that SmN (show STMN1 Proteins) expression reduces the level of mature U2 snRNP (show LSM2 Proteins), leading to alternative splicing

  6. The methylation patterns of the promoters of MTHFR (show MTHFR Proteins) and SNRPN are associated with changes in sperm motility and morphology, which could lead to male infertility.

  7. Human amniotic fluid mesenchymal stem cells contain a unique epigenetic signature during in vitro cell culture. H19 (show NCKAP1 Proteins) and KCNQ1OT1 possessed a substantial degree of hypermethylation status, and variable DNA methylation (show HELLS Proteins) patterns of SNRPN was observed.

  8. In the skeletal muscle of neonate pigs, both NECD (show NDN Proteins) and SNRPN were maternally imprinted, while UBE3A (show ube3a Proteins) was not imprinted.

  9. genetic association studies using 1,000 white subjects from Midwestern United States: Three copy number variations (CNV) in PWCR (show NDN Proteins) are associated with body fat mass, with a higher copy number (CN) associated with an increase of in body fat mass.

  10. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells.

Mouse (Murine) Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) interaction partners

  1. we found that either knockdown of Nr4a1 (show NR4A1 Proteins) or 3, 3'- Diindolylmethane (DIM), an Nr4a1 (show NR4A1 Proteins) antagonist, were able to rescue the effects of SNRPN knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN deletion disorders. We thus concluded that maintaining the proper level of SNRPN is critical in cortical neurodevelopment.

  2. The androgenetic patterns of H19, Snrpn, and Mest were maintained even after differentiation of germline-derived pluripotent stem cells(gPS) into neural stem cells(NSC), whereas the fully unmethylated status of Ndn in SSCs was altered to somatic patterns in gPS cells and gPS-NSCs.

  3. These data indicate that oocytes undergo time-dependent demethylation of Snrpn differentially methylated regions during the process of postovulatory aging.

  4. Oocytes vitrification could lead to the loss of DNA methylation (show HELLS Proteins) of imprinted genes (H19 (show NCKAP1 Proteins), Peg3, and Snrpn) in mouse blastocysts, which is mainly caused by the reductions of DNMTs after vitrification of oocytes.

  5. These results support a model in which transcription from the Snrpn upstream exons directs the maternal imprint at the PWS-IC

  6. Snrpn gene is imprinted, with monoallelic expression from the paternal allele in brain and heart.

  7. the ATG-to-AAG (show C16orf35 Proteins) mutation causes a 15-fold or more increase in translation of the downstream ORF in two fusion constructs, and it is likely that similar translational control affects the normal Snurf-Snrpn (show SNURF Proteins) transcript as well

  8. The tissue-specific methylation of the mouse conserved activator sequence and its methylation-sensitive enhancer activity may control expression of imprinting center transcripts, establishing and/or maintaining imprinting in the Snrpn locus.

  9. Mouse model for Prader-Willi syndrome. Deletion of Snrpn gene and putative imprinting-centre is associated with absent expression of the imprinted genes Zfp127, Ndn (show NDN Proteins) and Ipw, and phenotypes similar to those found in Prader-Willi infants.

Cow (Bovine) Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) interaction partners

  1. SNRPN methylation profiles previously observed in mouse and human studies are also conserved in cattle

  2. Results suggest that artificial reproductive techniques, such as prolonged in vitro culture and SCNT, lead to abnormal reprogramming of imprinting of SNRPN gene by altering methylation levels at this locus.

Rhesus Monkey Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) interaction partners

  1. SNURF/SNRPN (show SNURF Proteins) IC is differentially methylated, consistent with monoallelic expression in embryonic stem cells.

SNRPN Protein Profile

Protein Summary

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

Gene names and symbols associated with SNRPN

  • small nuclear ribonucleoprotein polypeptide-like (SNRPL)
  • small nuclear ribonucleoprotein polypeptides B and B1 (snrpb)
  • small nuclear ribonucleoprotein polypeptide N (SNRPN)
  • small nuclear ribonucleoprotein N (Snrpn)
  • small nuclear ribonucleoprotein polypeptide N (Snrpn)
  • small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 (snrpn)
  • SNRPN upstream reading frame (SNURF)
  • Small nuclear ribonucleoprotein-associated protein N (SNRPN)
  • 2410045I01Rik protein
  • FE 294 protein
  • FE294 protein
  • FE 294 psi protein
  • FE294 psi protein
  • HCERN3 protein
  • Peg4 protein
  • PWCR protein
  • Pwcr1 protein
  • QflA-11237 protein
  • QtrA-10022 protein
  • RT-LI protein
  • SM-D protein
  • Sm-N protein
  • SmN protein
  • SNRB' protein
  • snRNP-N protein
  • SNRPB' protein
  • SNRPN protein
  • SNURF protein
  • SNURF-SNRPN protein
  • zgc:77315 protein

Protein level used designations for SNRPN

sm protein B' , sm-B' , smB' , small nuclear ribonucleoprotein B , small nuclear ribonucleoprotein B' , small nuclear ribonucleoprotein polypeptide B/B' , small nuclear ribonucleoprotein-associated protein B' , snRNP-B' , snRNP-associated protein , SM protein N , sm protein D , small nuclear ribonucleoprotein-associated protein N , tissue-specific splicing protein , sm protein N , sm-D , sm-N , snRNP-N , tissue-specific-splicing protein , FE294 gene for snRNP-associated polypeptide N , FE294 psi pseudogene , smN , small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51 , small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 , small nuclear ribonucleoprotein N , SNRPN upstream reading frame , SNRPN upstream reading frame protein , small nuclear ribonucleoprotein polypeptide N , SNRPN upstream reading frame product , Sm protein N

GENE ID SPECIES
395298 Gallus gallus
402966 Danio rerio
6638 Homo sapiens
20646 Mus musculus
81781 Rattus norvegicus
780877 Bos taurus
100174649 Pongo abelii
100341967 Oryctolagus cuniculus
479012 Canis lupus familiaris
106780830 Equus caballus
100730238 Cavia porcellus
100626432 Sus scrofa
101113797 Ovis aries musimon
379853 Xenopus laevis
711028 Macaca mulatta
102133696 Macaca fascicularis
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