Sodium Channel, Nonvoltage-Gated 1, beta Proteins (SCNN1B)

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Additionally we are shipping SCNN1B Antibodies (251) and SCNN1B Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SCNN1B 6338 P51168
SCNN1B 20277 Q9WU38
Rat SCNN1B SCNN1B 24767 P37090
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Top SCNN1B Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Yeast Dog His tag   1 mg 60 to 71 Days
$2,137.67
Details
Yeast Sheep His tag   1 mg 60 to 71 Days
$2,552.00
Details
Escherichia coli (E. coli) Human Un-conjugated   1 mg 11 to 18 Days
$1,762.47
Details

SCNN1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,

More Proteins for Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) Interaction Partners

Human Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) interaction partners

  1. SCNN1B was not associated with Salt Sensitivity of Blood Pressure in rare variant analyses.

  2. Proteolytic cleavage activates epithelial sodium channel (SCNN) by removal of specific segments in finger domains of alpha and gamma subunits. Data suggest that the lower "palm" domain of SCNN1A is essential for allosteric activation of the SCNN heterotetramer [SCNN1A(1)-SCNN1B-SCNN1A(2)-SCNN1G].

  3. In the present study, the SCNN1G gene was associated with 24-h urinary sodium excretion but was not related to blood pressure. The SCNN1A and SCNN1B genes were not associated with blood pressure either.

  4. No association was found between single nucleotide polymorphism rs12447134 of sodium channel, nonvoltage-gated 1, beta protein (SCNN1B) gene with the onset of disease hypertension.

  5. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations

  6. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  7. hENaC incorporating the Liddle-mutated beta-subunit lacks one or more PKC phosphorylation sites, thereby significantly reducing the inhibitory effect of PKC on Na(+) channel activity, whereas hENaC incorporating Liddle-mutated gamma-subunits remains as susceptible to PKC as wild-type hENaC.

  8. deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.

  9. Results identify SCNN1B as a tumor-suppressive function that triggers UPR in gastric cancer cells, with implications for its potential clinical applications as a survival biomarker in gastric cancer patients.

  10. These results indicated a significant association between EH and SCNN1B methylation, which was affected by age, gender and antihypertensive therapy.

  11. Three nonsynonymous amino acid variants in SCNN1B in nonwhite Cystic fibrosis patients with non-diagnostic CFTR genotypes was

  12. These results do not suggest an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of Indo-Aryan ancestry.

  13. The transcriptional expression of alpha, beta, and gamma subunits of ENaC was elevated in nasal polyp compared to nasal mucosa

  14. causative mutation for Liddle's syndrome (LS) in this patient was identified to be a novel frameshift mutation. DNA sequencing resulted in exon 13 of SCNN1B gene: SCNN1B NM_000336.2:c.1 724_1730dupGGCCCAC [p.Pro5 75Argfs*17].

  15. analysis of a novel frameshift mutation in the betaENaC gene in an isolated case of Liddle syndrome

  16. Suggest that SCNN1B gene has important roles in blood pressure regulation in the Han Chinese population.

  17. significant association between the rs3743966 SNP in intron 12 of epithelial sodium channel beta-subunit and essential hypertension

  18. Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 induction enhances migration.

  19. ENaCbeta but not ENaCalpha expression is significantly lower in severe preeclampsia compared with normal pregnancy.

  20. WNK4 inhibits ENaC channel activity independently of Nedd4-2-mediated ENaC ubiquitination.

Mouse (Murine) Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) interaction partners

  1. Apical fluid shear stress specifically downregulates beta-ENaC and gamma-ENaC subunits at the transcriptional level through an unidentified heat-insensitive paracrine basolateral factor in collecting duct principal cells.

  2. Casein kinase 2 phosphorylation is an important regulator of ENaC activity and sodium handling by the aldosterone sensitive distal nephron.

  3. N-linked glycans on each subunit are required for proper folding, maturation, surface expression, and function of the epithelial sodium channel.

  4. Scnn1b-Tg mice exhibited an approximately 50% reduction mucociliary clearance

  5. Loss of betaENaC function resulted in meibomian gland disease and severe ocular surface damage that phenocopied aspects of human pseudohypoaldosteronism-1 MG disease and was sex dependent.

  6. The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.

  7. Nedd4-2-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  8. Data indicate that insulin receptor (InsR) is important for epithelial sodium channel (ENaC) activity.

  9. Our findings are consistent with the role of betaENaC as a vascular smooth muscle cell mechanosensor and function of evolutionarily related nematode degenerin proteins.

  10. These data suggest that adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity in the kidney.

  11. Cys substitutions at sites in the wrist domains of the beta and gamma subunits alter the Na+ self-inhibition response.

  12. ENaC is not a passive passenger in regulated epithelial vesicle trafficking, but plays a role in establishing and maintaining the pool of vesicles that respond to cAMP stimulation.

  13. These findings demonstrate that myogenic constriction in afferent arterioles is dependent on normal expression of betaENaC

  14. loss of beta-ENaC associated with early signs of renal injury and increased mean arterial pressure

  15. generation of transgenic mice with airway-specific overexpression of the epithelial Na(+) channel (ENaC) is an alternative approach to mimic cystic fibrosis ion transport pathophysiology in the lung

  16. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.

  17. Il-6 activates ENaC-beta channels in cortical collecting duct cells.

  18. Dot1a and AF9 downregulate Na(+) transport, most likely by regulating ENaC mRNA and subsequent protein expression and ENaC activity.

  19. Beta-ENaC is an important mediator of renal myogenic constriction-mediated renal blood flow autoregulation in vivo.

  20. pore regions from the three ENaC subunits have an asymmetric organization

SCNN1B Protein Profile

Protein Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Gene names and symbols associated with SCNN1B

  • sodium channel epithelial 1 beta subunit (SCNN1B)
  • sodium channel, non voltage gated 1 beta subunit (scnn1b)
  • sodium channel, nonvoltage-gated 1 beta (Scnn1b)
  • sodium channel epithelial 1 beta subunit (Scnn1b)
  • BESC1 protein
  • BETA-ENAC protein
  • ENaCb protein
  • ENaCbeta protein
  • RNENACB protein
  • SCNEB protein
  • SCNN1B protein

Protein level used designations for SCNN1B

sodium channel, nonvoltage-gated 1, beta , sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) , amiloride-sensitive sodium channel subunit beta , amiloride-sensitive sodium channel subunit beta 1 , beta-ENaC , beta-NaCH , epithelial Na(+) channel subunit beta , epithelial sodium channel beta-2 subunit , epithelial sodium channel beta-3 subunit , nasal epithelial sodium channel beta subunit , nonvoltage-gated sodium channel 1 subunit beta , Amiloride-sensitive sodium channel subunit beta , epithelial amiloride-sensitive sodium channel beta subunit , SCNEB , epithelial sodium channel ENaC beta subunit , epithelial sodium channel, beta subunit , amiloride sensitive epithelial sodium ion channel beta subunit , epithelium sodium channel beta subunit , ENaC beta , amiloride sensitive sodium channel beta1 subunit , sodium channel, nonvoltage-gated, type I, beta

GENE ID SPECIES
100069008 Equus caballus
453984 Pan troglodytes
700093 Macaca mulatta
779891 Xenopus (Silurana) tropicalis
100476005 Ailuropoda melanoleuca
100590266 Nomascus leucogenys
6338 Homo sapiens
489972 Canis lupus familiaris
100009564 Oryctolagus cuniculus
100627971 Sus scrofa
100170325 Ovis aries
20277 Mus musculus
100270805 Cavia porcellus
24767 Rattus norvegicus
533355 Bos taurus
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