anti-Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) Antibodies

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. Additionally we are shipping SCN2A Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCN2A 110876  
SCN2A 24766 P04775
SCN2A 6326 Q99250
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Top anti-SCN2A Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mammalian Mouse Un-conjugated ISt, IHC, WB   5 mL Log in to see 2 to 6 Days
$366.67
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of U-87MG and K562 cells, using SCN2A antibody. 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated IHC (p) <b>Immunohistochemistry</b> analysis of SCN2A Antibody in paraffin-embedded human brain tissue. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Rat Mouse Biotin IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of mouse brain with Scn2a1 monoclonal antibody, clone CJ6 (Biotin) . 100 μg Log in to see 11 to 12 Days
$648.60
Details
Rat Mouse Un-conjugated IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of mouse brain with Scn2a1 monoclonal antibody, clone CJ6 . 100 μg Log in to see 11 to 12 Days
$517.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.01 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated IHC, IHC (p)   100 μL Log in to see 7 to 9 Days
$522.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p)   100 μL Log in to see 7 to 9 Days
$757.17
Details
Rat Rabbit Un-conjugated IHC, WB   50 μL Log in to see 11 to 16 Days
$683.57
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

Top referenced anti-SCN2A Antibodies

  1. Mammalian Monoclonal SCN2A Primary Antibody for ISt, IHC - ABIN1304839 : Gazina, Leaw, Richards, Wimmer, Kim, Aumann, Featherby, Churilov, Hammond, Reid, Petrou: 'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour. in Human molecular genetics 2015 (PubMed)
    Show all 39 Pubmed References

More Antibodies against SCN2A Interaction Partners

Mouse (Murine) Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) interaction partners

  1. in the absence of Nav1.6 (show SCN8A Antibodies) expression, the AIS (show AR Antibodies) is occupied by Nav1.2 channels. However, APs (show SH2B2 Antibodies) are generated in the AIS (show AR Antibodies), and differences in AP propagation to soma and dendrites are minimal.

  2. This study demonstrated that brain-specific (show CALY Antibodies) Nav subunits revealed the expression of Nav 1.2 by most substantia nigra dopaminergic neurons.

  3. results therefore indicate that, while Nav1.1 (show SCN1A Antibodies) is expressed in MEG (show PTPN4 Antibodies)-derived inhibitory neurons, Nav1.2 is expressed in caudal (show CAD Antibodies) ganglionic eminence-derived disinhibitory interneurons in addition to excitatory neurons

  4. Inhibitory postsynaptic currents in NaV1.2 adult neurons were larger and the expression level of Scn2a mRNA was lower compared with the wild-type.

  5. Reducing of NaV1.2-mediated currents in interneurons promoted recurrent network activity.

  6. interaction with Sin3B influences Na(v)-channel trafficking or stability in the membrane.

  7. Nav1.2 expression levels are elevated in the brain of sodium channel blocker-treated animamls with experimental autoimmune encephalomyelitis.

  8. The present findings show a polarised distribution of Na(v)1.2 along the neuronal surface of granule cells and suggest its primary involvement in the transmission of information from granule cells to Purkinje cells.

  9. Immunohistochemical stainings of mouse cerebellum with a NaV1.2-specific antibody revealed a prominent increase in staining of the molecular layer during postnatal development.

  10. However, Na(v)1.2 channels show a greater accumulation of inactivation at higher frequencies of stimulation (20-100 Hz) than Na(v)1.6 and thus are likely to generate lower frequencies of firing.

Human Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A) interaction partners

  1. SCN1A (show SCN1A Antibodies) and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures

  2. We utilized a targeted next generation sequencing (NGS) approach on a girl with early-onset seizures and Rett-like features, including autistic behavior, limited hand function with chorea, and profound intellectual disability, to identify novel missense mutation (c.1270G>A; p.V424M) in the SCN2A gene, which encodes the alphaII-subunit of the voltage-gated Na+ channel (Nav1.2).

  3. SCN2A autism spectrum disorder (ASD (show ARSD Antibodies))-associated variants dampened or eliminated channel function in transfected HEK293 cells. A compartmental model of developing excitatory neurons demonstrated that all ASD (show ARSD Antibodies) variants, regardless of their mechanism of action, resulted in deficits in neuronal excitability. Corresponding analysis of mature neurons predicted minimal change in neuronal excitability.

  4. clinical and experimental data suggest a correlation between age at disease onset, response to sodium channel blockers and the functional properties of mutations in children with SCN2A-related epilepsy.

  5. The most frequently mutated gene in early-onset seizure and severe developmental delay disorders was SCN2A (11 patients, 3%), occurring de novo in all patients.

  6. Data indicate eight new cases with overlapping duplications at 2q24 and SCN3A (show SCN3A Antibodies) was not involved in duplication, suggesting that having an extra copy of SCN2A has an effect on epilepsy pathogenesis.

  7. This study demonstrated the association of SCN2A rs1864885 A > G, in Japanese childhood encephalopathy patients.

  8. Our findings broaden the clinical spectrum observed with SCN2A gain-of-function mutations, showing that fairly different biophysical mechanisms can cause a convergent clinical phenotype of neonatal seizures and later onset episodic ataxia.

  9. We argue that very rare, loss-of-function mutations at SCN2A act in a moderately penetrant manner to increase the risk of developing several neuropsychiatric disorders including seizure disorders, intellectual disability, autism and schizophrenia.

  10. Mutations in SCN1A (show SCN1A Antibodies) and SCN2A are a predisposing factor of acute encephalopathy with biphasic seizures and late reduced diffusion

SCN2A Antigen Profile

Protein Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with SCN2A

  • sodium voltage-gated channel alpha subunit 2 (SCN2A) antibody
  • sodium channel protein type 2 subunit alpha (LOC100217927) antibody
  • sodium channel protein type 2 subunit alpha (LOC100389294) antibody
  • sodium channel protein type 2 subunit alpha (LOC100484218) antibody
  • sodium channel, voltage-gated, type II, alpha (Scn2a) antibody
  • sodium voltage-gated channel alpha subunit 2 (Scn2a) antibody
  • sodium channel protein type 2 subunit alpha (LOC478773) antibody
  • sodium channel, voltage-gated, type II, alpha subunit (SCN2A) antibody
  • 6430408L10 antibody
  • A230052E19Rik antibody
  • BFIC3 antibody
  • BFIS3 antibody
  • BFNIS antibody
  • EIEE11 antibody
  • HBA antibody
  • HBSCI antibody
  • HBSCII antibody
  • Na(v)1.2 antibody
  • NAC2 antibody
  • NachII antibody
  • Nav1.2 antibody
  • RII/RIIA antibody
  • RNSCPIIR antibody
  • SCN antibody
  • SCN2A antibody
  • SCN2A1 antibody
  • Scn2a2 antibody
  • ScpII antibody

Protein level used designations for SCN2A

sodium channel, voltage-gated, type II, alpha subunit , sodium channel protein type 2 subunit alpha-like , sodium channel, voltage-gated, type II, alpha polypeptide 1 , RIIA sodium channel protein , alternative product , sodium channel protein brain II subunit alpha , sodium channel protein type 2 subunit alpha , sodium channel protein type II subunit alpha , sodium channel protein, brain II subunit alpha , sodium channel voltage-gated type II alpha polypeptide , sodium channel, voltage-gated, type 2, alpha 1 polypeptide , sodium channel, voltage-gated, type 2, alpha 1 subunit , voltage-gated sodium channel subunit alpha Nav1.2 , HBSC II , sodium channel protein, brain type 2 alpha subunit , sodium channel, voltage-gated, type II, alpha 1 polypeptide , sodium channel, voltage-gated, type II, alpha 2 polypeptide , voltage-gated sodium channel subtype II , voltage-gated sodium channel II , sodium channel protein , sodium channel, type II, alpha polypeptide , sodium channel, voltage-gated, type II, alpha 1

GENE ID SPECIES
459700 Pan troglodytes
703298 Macaca mulatta
100016409 Monodelphis domestica
100051816 Equus caballus
100217927 Taeniopygia guttata
100389294 Callithrix jacchus
100484218 Ailuropoda melanoleuca
110876 Mus musculus
24766 Rattus norvegicus
6326 Homo sapiens
395945 Gallus gallus
478773 Canis lupus familiaris
396588 Sus scrofa
539718 Bos taurus
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