SCN2A antibody (AA 51-150) (Biotin)

Catalog No. ABIN735940

This Rabbit Polyclonal antibody specifically detects SCN2A in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for SCN2A antibody (AA 51-150) (Biotin) (ABIN735940)

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN2A antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SCN2A Antibody (Biotin)

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SCN2A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SCN2A

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Alternative Name: SCN2A

Background:

Synonyms: sodium channel voltage-gated type II alpha, sodium channel, voltage-gated, type II, alpha isoform 2, HBSC II, NAC2, Scn2a, SCN2A_HUMAN, Sodium channel protein type II subunit alpha, Sodium channel protein type 2 subunit alpha, Sodium channel protein type II subunit alpha, Sodium channel protein, brain II subunit alph, Voltage-gated sodium channel subunit alpha Nav1.2, Voltage gated sodium channel subunit alpha Nav1.2, BFIC3, HBA, HBSCI, HBSCII, Nav1.2, NAC2, Nav1.2, SCN2A1, SCN2A2.

Background: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene ID: 6326