SCN2A antibody (C-Term)

Catalog No. ABIN6658123

Supplier Product No.: 200-301-g19

The Mouse Monoclonal anti-SCN2A antibody is suitable to detect SCN2A in samples from Rat. It has been validated for IHC, WB, IP and FM.

Quick Overview for SCN2A antibody (C-Term) (ABIN6658123)

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCN2A antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Clone: S69-3

Product Details anti-SCN2A Antibody

Binding Specificity: C-Term

Supplier Product No.: 200-301-g19

Supplier: Rockland

Purpose: Nav1.2 Antibody

Purification: Anti-Nav1.2 Antibody was purified by Protein G chromatography.

Sterility: Sterile filtered

Immunogen: Nav1.2 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.2.

Isotype: IgG2a

Application Details

Application Notes:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: 0.1-1.0 μg/mL

IF_Microscopy_Dilution: 1.0-10 μg/mL

Western_Blot_Dilution: 1 μg/mL

Comment:

Anti-Nav1.2 Antibody is tested for use in WB, IP, and IHC. Expect a band approximately ~250kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.09 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SCN2A

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Alternative Name: Nav1.2

Background:

Synonyms: SCN, SCN2A, ScpII, NachII, Nav1.2, Scn2a2, RII/RIIA, RNSCPIIR, Scn2a1, Sodium channel protein type 2 subunit alpha, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated Sodium channel subunit alpha Nav1.2

Background: Nav1.2 is a protein that in humans is encoded by the SCN2A gene. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain and stroke.

Gene Name: Scn2a

Gene ID: 24766

NCBI Accession: NP_036779

UniProt: P04775