anti-Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) Antibodies

The protein encoded by SLC10A1 belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Additionally we are shipping SLC10A1 Kits (7) and SLC10A1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC10A1 20493 O08705
SLC10A1 6554 Q14973
SLC10A1 24777 P26435
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Top anti-SLC10A1 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SLC10A1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HT1080 cell lysate Host:  Rabbit  Target Name:  SLC10A1  Sample Type:  HT1080  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  1ug/ml  Peptide Concentration:  5ug/ml  Lysate Quantity:  25ug/lane/lane  Gel Concentration:  0.12 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- SLC10A1 Picoband antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Observed bind size: 45, 50KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SLC10A1 antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Anti-SLC10A1 antibody, Western blotting All lanes: Anti SLC10A1  at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 1: Rat Brain Tissue Lysate at 50ug Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated FACS, WB SLC10A1 Antibody (C-term) (ABIN651897) western blot analysis in K562 cell line lysates (15 µg/lane). This demonstrates the SLC10A1 antibody detected the SLC10A1 protein (arrow). SLC10A1 Antibody (C-term) (ABIN651897) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 200 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Liver, antibody was diluted at 1:100. 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB Mouse kidney cells probed with Rabbit Anti-NTCP/SLC10A1 Polyclonal Antibody, FITC Conjugated (ABIN675908-FITC) (green) at 1:50 for 40 minutes compared to control cells (red). Mouse liver cells probed with Rabbit Anti-NTCP/SLC10A1 Polyclonal Antibody, FITC Conjugated (ABIN675908-FITC) (green) at 1:50 for 40 minutes compared to control cells (red). 100 μL Log in to see 3 to 7 Days
$317.90
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Alexa Fluor 488 FACS, IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details

Top referenced anti-SLC10A1 Antibodies

  1. Human Polyclonal SLC10A1 Primary Antibody for FACS, WB - ABIN651897 : Takamatsu, Shimomura, Kamada, Maeda, Sobajima, Hikita, Iijima, Okamoto, Misaki, Fujiyama, Nagamori, Kanai, Takehara, Ueda, Kuroda, Miyoshi: Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy. in Glycobiology 2018 (PubMed)

More Antibodies against SLC10A1 Interaction Partners

Mouse (Murine) Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) interaction partners

  1. NTCP and OATP isoforms cooperatively form a stable bile acid uptake machinery in mice, whereas NTCP is predominant in humans.

  2. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep in liver.

  3. Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate

  4. central role in hepatic uptake of conjugated bile acids and hepatitis B virus preS1/Myrcludex B binding

  5. mNTCP was found to be unable to support either HBV or HDV infection, although it can bind to pre-S1 of HBV L protein and is functional in transporting substrate taurocholate.

  6. hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis

  7. Large variations in hepatic bile salt flux have minor effects on expression of murine Ntcp and Bsep in vivo, suggesting that these transporters are abundantly expressed and able to accommodate a wide range of 'physiological' bile salt fluxes.

  8. Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression.

  9. Reduced levels of HNF-1alpha, RXRalpha, and RARalpha in CBDL FXR-/- mice and reduced DNA binding in CA-fed FXR-/- mice, despite unchanged Ntcp levels, indicate that these factors may have a minor role in regulation of mouse Ntcp during cholestasis

  10. The C51A and C106A mutants of Slc10a2 showed significantly reduced TCA uptake, while no apparent difference in TCA uptake was observed for the Slc10a1-C44A mutant.

  11. Ntcp and Bsep are regulated by age, gender, cholestyramine, and bile acid, but resistant to induction by most microsomal enzyme inducers.

  12. mouse Ntcp is regulated by HNF-4alpha via a conserved distal cis-element independently of HNF-1alpha.

  13. Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Ntcp uptake transporter in mouse liver.

  14. In the liver, histone H3 in the proximal promoter of Ntcp is hyperacetylated, whereas acetylation in the kidney and cerebrum is minimal.

  15. Report Role of hepatic Ntcp transporter in prevention of bile acid toxicity after partial hepatectomy in mice.

Human Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1) interaction partners

  1. The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of liver cancer and hepatocellular carcinoma.

  2. NTCP upregulated hepatitis B virus (HBV) transcription via farnesoid X receptor alpha (FxRalpha)-mediated activation of the HBV EN2/core promoter at the postentry step in a manner that was dependent on the bile acid (BA)-transport function of NTCP, which was blocked by MyrB.

  3. The results from our study suggest that SLC10A1 mutations should be screened for in individuals with asymptomatic hypercholanemia.

  4. we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research

  5. In this study, the authors identified new hepatitis B virus isolates from one homozygous S267F NTCP mutation carrier and confirmed new isolates also use wildtype-NTCP as a cellular receptor. Furthermore, we demonstrated S267F variant of NTCP, though inefficient, is still a functional receptor for hepatitis B virus entry.

  6. These findings suggest that host factors unique to HepaRG cells are required for efficient infection by serum-derived HBV, and factors other than NTCP contribute to balanced viral antigen production following infection by cell culture-derived HBV.

  7. These kinetic results provide important complementary data on the substrate selectivity and specificity of NTCP to transport bile acids.

  8. Results show that NTCP inhibition suppressed the in vivo spread of HBV infection in the presence of uninfected hepatocytes. Livers in CHB patients contained varying degrees of HBsAg-negative hepatocytes, as evidenced by immunohistochemistry.

  9. These results uncover NTCP as a mediator of innate antiviral immune responses in the liver.

  10. For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed.

  11. the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility.

  12. The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population.

  13. The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection.

  14. In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus.

  15. Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury.

  16. We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese

  17. The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection.

  18. Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor.

  19. We describe for the first time a mouse liver cell line that, solely upon expression of the hNTCP receptor, becomes susceptible to HBV.

  20. This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection.

SLC10A1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids\; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

Gene names and symbols associated with SLC10A1

  • solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (Slc10a1) antibody
  • solute carrier family 10 member 1 (SLC10A1) antibody
  • solute carrier family 10 member 1 (Slc10a1) antibody
  • NTCP antibody
  • Ntcp1 antibody
  • SBACT antibody

Protein level used designations for SLC10A1

Na(+)/bile acid cotransporter , Na(+)/taurocholate transport protein , bile acid cotransporting polypeptide , sodium bile acid cotransporting polypeptide , sodium-taurocholate cotransporting polypeptide , sodium/bile acid cotransporter , sodium/taurocholate cotransporting polypeptide , Na/taurocholate cotransporting polypeptide , cell growth-inhibiting gene 29 protein , growth-inhibiting protein 29 , sodium/taurocholate cotransporter , solute carrier family 10 (sodium/bile acid cotransporter family), member 1 , solute carrier family 10 member 1 , NA-dependent cholate transporting protein , sodium-dependent bile acid cotransporter , sodium-dependent taurocholate cotransporting polypeptide , solute carrier family 10, member 1

GENE ID SPECIES
20493 Mus musculus
6554 Homo sapiens
24777 Rattus norvegicus
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