anti-Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Antibodies

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC22A8 9376 Q8TCC7
SLC22A8 19879 O88909
SLC22A8 83500 Q9R1U7
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Top anti-Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SLC22A8 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human heart 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269516 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269516 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of OCT3 expression in HT29 (A), JAR (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa cells, using OCT3 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using OCT3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: SLC22A8 Antibody [NBP1-92396] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Immunocytochemistry/Immunofluorescence: SLC22A8 Antibody [NBP1-92396] - Staining of human cell line U-251 MG shows positivity in nucleus but not nucleoli & golgi apparatus. 0.1 mL Log in to see 7 to 9 Days
$494.38
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti OAT-3 Polyclonal Antibody, Unconjugated (ABIN670821) at 1:200 followed by conjugation to the secondary antibody and DAB staining Mouse kidney lysates probed with OAT-3 Polyclonal Antibody, Unconjugated  at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL Log in to see 3 to 7 Days
$329.45
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of 231 , using SLC22A8 antibody.  The lane on the left is treated with the antigen-specific peptide. ABIN6277451 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of SLC22A8 in lysates of fetal heart?, using SLC22A8 Antibody(ABIN6270363). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 11 to 13 Days
$366.77
Details

Top referenced anti-Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Antibodies

  1. Human Polyclonal SLC22A8 Primary Antibody for IF (p), IHC (p) - ABIN670821 : Zhou, Yu, Zhang, Liu, Lu: Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice. in Planta medica 2014 (PubMed)
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  2. Rat (Rattus) Polyclonal SLC22A8 Primary Antibody for IHC (fro), WB - ABIN548996 : Kusuhara, Sekine, Utsunomiya-Tate, Tsuda, Kojima, Cha, Sugiyama, Kanai, Endou: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SLC22A8 Primary Antibody for IHC (fro) - ABIN548994 : Cha, Sekine, Fukushima, Kanai, Kobayashi, Goya, Endou: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. in Molecular pharmacology 2001 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Solute Carrier Family 22 (Organic Anion Transporter), Member 8 Interaction Partners

Human Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. Sgk1 stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo.

  2. is richly expressed in the kidney, where it plays critical roles in the secretion, from the blood to urine, of clinically important drugs.

  3. SLC22A8 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

  4. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1/OAT3.

  5. The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.

  6. high capacity p-cresyl sulfate trasnporter

  7. PPIs inhibit [(3)H]MTX transport via hOAT3 inhibition.

  8. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 in lymphoma cells and the high affinity of bendamustine for this transporter.

  9. Pemetrexed is a superior substrate to methotrexate for hOAT3.

  10. In HEK293-Flp-In cells, the OAT3-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

  11. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells.

  12. transport of xanthurenic acid by OAT1 and OAT3

  13. Both hOAT1 and hOAT3 markedly stimulated the uptake of kynurenic acid into oocytes.

  14. High urine OAT1, OAT3 and OAT4 is associated with severe acute kidney injury.

  15. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1, and OAT3

  16. Intergenic polymorphism rs10792367 between OAT1 and OAT3 is not associated with hypertension, but appears to be involved in between-individual variations in antihypertensive responses to hydrochlorothiazide.

  17. Interaction of human OAT3 with 2,3-dimercapto-1-propanesulfonic acid (DMPS) determines the effect of human OAT3 on basolateral DMPS uptake in rabbit renal proximal tubules.

  18. Angiotensin II inhibited hOAT3 activity through the activation of PKCalpha, which led to an acceleration of hOAT3 endocytosis.

  19. elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs

  20. polymorphisms in the OAT3 gene did not appear to be associated with changes in renal and tubular secretory clearance of pravastatin

Mouse (Murine) Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) interaction partners

  1. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol.

  2. OCT2-independent pathway of cisplatin-induced renal injury that is mediated by the organic anion transporters OAT1 and OAT3, is reported.

  3. OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney

  4. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3).

  5. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  6. Oat3 also plays a role in bioenergetic pathways.

  7. At the protein level, mOat3 and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.

  8. The results are consistent with a contribution of OAT3 and possibly OAT1 to renal creatinine secretion in mice.

  9. DAT and Oct3 modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling

  10. functional differences in the relative importance of OAT1 and OAT3 in antiviral handling in developing and mature tissue

  11. the ontogenic pattern of expression of OAT1 and OAT3 in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  12. Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter)

  13. For PAH, FL, and estrone sulfate, all Oat3-mediated transport was Na dependent in choroid plexus

  14. Results indicate that mOAT3 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.

  15. These results indicate that the tissue-specific expression of hOAT3 might be regulated by the concerted effect of genetic (HNF1alpha and HNF1beta) and epigenetic (DNA methylation) factors.

  16. mOat3 plays an important role as a basolateral transport pathway of PGE(2) in the distal nephron.

  17. urinary excretion of topotecan hydroxyl acid is accounted for by transport via OAT3, as well as glomerular filtration, in both rats and humans

  18. Functional Oat3 is necessary for proper elimination of xenobiotic and endogenous compounds in vivo.

  19. despite sharing close overall sequence homology, Oat1, Oat3, and Oat6 have signficantly different binding pockets

  20. Oat3 interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin.

Solute Carrier Family 22 (Organic Anion Transporter), Member 8 (SLC22A8) Antigen Profile

Protein Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with SLC22A8

  • solute carrier family 22 member 8 (SLC22A8) antibody
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8) antibody
  • solute carrier family 22 member 8 (Slc22a8) antibody
  • Oat3 antibody
  • OCT3 antibody
  • Roct antibody

Protein level used designations for SLC22A8

hOAT3 , organic anion transporter 3 , solute carrier family 22 member 8 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3 , pOAT3

GENE ID SPECIES
9376 Homo sapiens
19879 Mus musculus
83500 Rattus norvegicus
404128 Bos taurus
100008845 Oryctolagus cuniculus
451274 Pan troglodytes
100172896 Pongo abelii
476049 Canis lupus familiaris
407774 Sus scrofa
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