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SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (49) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (5) and many more products for this protein.
Showing 10 out of 99 products:
Human Polyclonal SLC6A4 Primary Antibody for IEM, ICC - ABIN617913
Sur, Betz, Schloss: Localization of the serotonin transporter in rat spinal cord. in The European journal of neuroscience 1997
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Human Polyclonal SLC6A4 Primary Antibody for IF (p), IHC (p) - ABIN735983
Wang, Liu, Wang, Bai, Zhang, Sun, Wang: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. in Human & experimental toxicology 2013
Show all 6 Pubmed References
Human Polyclonal SLC6A4 Primary Antibody for ELISA, WB - ABIN250555
Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004
Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).
These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Antibodies) storage, and potentially for function of dSERT.
Adrenal glands from wild-type mice contained 5-HT (show DDC Antibodies) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (show HTR1A Antibodies) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (show DDC Antibodies) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.
These data suggest that correlated expression of Slc6a4 and Htr4 (show HTR4 Antibodies) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Antibodies).
Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.
genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders
Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.
These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (show DDC Antibodies) contributions of drug actions in vivo.
Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.
SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (show GUSB Antibodies) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (show GUSB Antibodies).
SERT protects trophoblast cells against apoptotic cell death in caspase-3 (show CASP3 Antibodies) independent pathway by terminating the 5-HT (show DDC Antibodies) signaling.
Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT (show DDC Antibodies). These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.
This paper contains kinetics data of serotonin receptor (show HTR1B Antibodies) binding.
Rhesus monkeys carrying the short rh5 (show RHO Antibodies)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.
An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.
Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.
A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Antibodies) site is found in animals possessing this polymorphism.
We find that the short allele of the rh5 (show RHO Antibodies)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.
rh5 (show RHO Antibodies)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.
short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.
carriers of the low-expressing rh5 (show RHO Antibodies)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.
evidence that the short allelic variant in rh5 (show RHO Antibodies)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants
this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors
the allelic distribution of solute carrier family-6 member-4 promoter region in Turkish athletes, is reported.
Both a genetic (5-HTTLPR) and cognitive (ruminative thinking) stress vulnerability may mutually increase the risk for stress-related abnormal eating patterns.
Overall, this investigation found evidence to suggest that 5-HTTLPR genotype affects the association of age and verbal episodic memory for males and females differently, with the predicted negative effect of S carriage present in males but not females.
The low expressing 5-HTTLPR genotype group (SA/SA genotype) is twice as likely to have a history of concussion compared to other genotypes.
Putatively detrimental effects of childhood trauma exposure on adult BDNF (show BDNF Antibodies) serum levels are influenced by 5-HTTLPR genotype in patients affected by bipolar disorder.
Increased attachment security from 4 to 6 forecasts increases in emotion regulation from 6 to 8 and decreased attachment security forecasts decreases in emotion regulation among the 5-HTTLPR short-allele homozygotes.
In summary, our results suggest that, by genetic association, the mu-opioid receptor (show OPRM1 Antibodies) interacts with serotonin transporter and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.
This study demonstrated that youth who attended away from angry faces and were homozygous for the S allele of the 5-HTTLPR polymorphism were more likely to experience a depressive episode onset across 18-months.
Our findings demonstrate that stressful family relationships not only initiate stress processes over the early life course, but also sensitize youth to stressors, and that 5-HTTLPR polymorphism interacts with stressful life experiences to predict heightened disease risk.
The results suggest a potential role of the 5-HTTLPR in self-reported everyday task planning and monitoring.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
, drosophila serotonin transporter
, cocaine-sensitive serotonin transporter
, sodium-dependent serotonin transporter
, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
, solute carrier family 6 member 4
, sodium-dependent serotonin transporter-like
, plasma membrane transporter for serotonin reuptake
, 5-hydroxytryptamine (serotonin) transporter
, 5HT transporter
, Sodium-dependent serotonin transporter (5HT transporter) (5HTT)
, transmembrane 5-HT transporter
, 5-hydroxytryptamine transporter
, Na+/Cl- dependent serotonin transporter
, serotonin transporter 1
, Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
, solute carrier family 6, member 4
, serotnin transporter