anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Antibodies

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse SLC6A4 SLC6A4 15567 Q60857
Anti-Human SLC6A4 SLC6A4 6532 P31645
Anti-Rat SLC6A4 SLC6A4 25553 P31652
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Top anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IEM, ICC, IF, IHC IHC image of neurons in raphe nucleus of rat brainstem. 0.1 mL Log in to see 2 to 3 Days
$550.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185394 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated WB Anti- SLC6A4 antibody, Western blotting All lanes: Anti SLC6A4  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: U87 Whole Cell Lysate at 40ug Lane 3: A549 Whole Cell Lysate at 40ug Lane 4: NEURO Whole Cell Lysate at 40ug Predicted bind size: 70KD Observed bind size: 70KD Anti- SLC6A4 antibody, Western blottingAll lanes: Anti SLC6A4  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: U87 Whole Cell Lysate at 40ug Lane 3: A549 Whole Cell Lysate at 40ug Lane 4: NEURO Whole Cell Lysate at 40ugPredicted bind size: 70KDObserved bind size: 90KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- SLC6A4 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti- SLC6A4 Picoband antibody, Western blotting All lanes: Anti SLC6A4  at 0.5ug/ml Lane 1: A549 Whole Cell Lysate at 40ug Lane 2: MM231 Whole Cell Lysate at 40ug Lane 3: HELA Whole Cell Lysate at 40ug Lane 4: 22RV1 Whole Cell Lysate at 40ug Predicted bind size: 70KD Observed bind size: 95KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat spleen tissue labeled with Anti-5-HTT/SLC6A4 Polyclonal Antibody, Unconjugated (ABIN735983) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded mouse embryo labeled with Anti-5-HTT/SLC6A4 Polyclonal Antibody, Unconjugated (ABIN735983) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$358.02
Details
Guinea Pig Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details

Top referenced anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies

  1. Human Polyclonal SLC6A4 Primary Antibody for IEM, ICC - ABIN617913 : Sur, Betz, Schloss: Localization of the serotonin transporter in rat spinal cord. in The European journal of neuroscience 1997 (PubMed)
    Show all 60 Pubmed References

  2. Human Polyclonal SLC6A4 Primary Antibody for IF (p), IHC (p) - ABIN735983 : Wang, Liu, Wang, Bai, Zhang, Sun, Wang: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. in Human & experimental toxicology 2013 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal SLC6A4 Primary Antibody for ELISA, WB - ABIN250555 : Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004 (PubMed)

More Antibodies against Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  2. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Antibodies) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (show NDN Antibodies)-knockout pups.

  2. Adrenal glands from wild-type mice contained 5-HT (show DDC Antibodies) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (show HTR1A Antibodies) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (show DDC Antibodies) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  3. These data suggest that correlated expression of Slc6a4 and Htr4 (show HTR4 Antibodies) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Antibodies).

  4. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  5. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  6. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  7. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (show DDC Antibodies) contributions of drug actions in vivo.

  8. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

  9. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (show GUSB Antibodies) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (show GUSB Antibodies).

  10. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (show CASP3 Antibodies) independent pathway by terminating the 5-HT (show DDC Antibodies) signaling.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Antibodies) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Rhesus monkeys carrying the short rh5 (show RHO Antibodies)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Antibodies) site is found in animals possessing this polymorphism.

  5. We find that the short allele of the rh5 (show RHO Antibodies)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  6. rh5 (show RHO Antibodies)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  8. carriers of the low-expressing rh5 (show RHO Antibodies)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  9. evidence that the short allelic variant in rh5 (show RHO Antibodies)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in 5-HTTLPR homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome.

  2. Pilot study demonstrated an increase in the SLC6A4 promoter DNA methylation (show HELLS Antibodies) levels in the saliva (show RAG1AP1 Antibodies) of children and adolescents with obsessive-compulsive disorder. DNA methylation (show HELLS Antibodies) provides one important epigenetic mechanism through which environmental influences can affect psychiatric disease risk.

  3. genetic association studies in population in Spain: Data suggest genetic polymorphisms in SLC6A4 promoter region are associated with ability to control food intake in overweight/obese subjects while in weight loss programs; SLC6A4 promoter polymorphisms interact with emotional eating to modulate weight loss. The biggest challenge for losing weight is the ability to control the amount of food eaten.

  4. findings suggest that the 5-HTTLPR S allele is associated with lower BMD (show BEST1 Antibodies) in adults younger than 50 years

  5. Depression remitted 5-HTTLPR S/Lg-carriers who experienced childhood trauma automatically avoided sad facial expressions relatively more than LaLa homozygotes with childhood trauma. Remitted LaLa-carriers who had not experienced childhood trauma, avoided sad faces relatively more than LaLa homozygotes with childhood trauma. Study did not find a main effect of childhood trauma.

  6. In a study of the genetic association between polymorphisms in the DAT1, SERT, COMT (show COMT Antibodies) and BDNF (show BDNF Antibodies) genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission

  7. Participants who assessed themselves with greater interdependence reported lower death anxiety/depression and showed decreased neural response to death-related words in emotion-related brain regions including the anterior cingulate, putamen, and thalamus. However, these results were evident in long/long allele carriers of the 5-HTTLPR but not in short/short allele carriers.

  8. 5-HTTLPR S-allele carriers showed a more negative relation between stress exposure and connectivity of the executive control network than L-allele homozygotes, specifically in the pre/postcentral gyrus, striatum, and frontal pole. In the default mode network, found a positive association between the GxE and supramarginal gyrus connectivity.

  9. Study found a significant interaction effect of the serotonin transporter-linked polymorphic region (5-HTTLPR) and the polymorphism in the serotonin 1A receptor gene (rs6295) on the connectivity within the right frontoparietal network, specifically in the middle frontal gyrus and inferior parietal lobule. Mean connectivity in the right inferior parietal lobule was positively correlated with working memory performance.

  10. SIDS (show IDS Antibodies) is associated with peripheral abnormalities in the 5-HT (show DDC Antibodies) pathway: compared with postmortem infant SIDS (show IDS Antibodies) and postmortem infant control samples, living infant controls had higher concentrations of serum 5-HT (show DDC Antibodies) and lower concentrations of 5-HIAA

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Antigen Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • Serotonin transporter (SerT) antibody
  • solute carrier family 6 member 4 (SLC6A4) antibody
  • huntingtin (LOC100540532) antibody
  • solute carrier family 6 member 4 (slc6a4) antibody
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4) antibody
  • solute carrier family 6 member 4 (Slc6a4) antibody
  • 5-HTT antibody
  • 5-HTTLPR antibody
  • 5HTT antibody
  • AI323329 antibody
  • CG4545 antibody
  • Dmel\\CG4545 antibody
  • DmSerT antibody
  • dsert antibody
  • dSERT1 antibody
  • hSERT antibody
  • Htt antibody
  • OCD1 antibody
  • Sert antibody
  • SERT1 antibody
  • SLC6A4 antibody

Protein level used designations for SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPECIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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