anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Antibodies

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (49) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC6A4 15567 Q60857
SLC6A4 6532 P31645
SLC6A4 25553 P31652
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Top anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies at antibodies-online.com

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IEM, ICC, IF, IHC IHC image of neurons in raphe nucleus of rat brainstem. 0.1 mL Log in to see 2 to 3 Days
$550.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185394 staining (1µg/ml) of Human Duodenum lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated WB Anti- SLC6A4 antibody, Western blotting All lanes: Anti SLC6A4  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: U87 Whole Cell Lysate at 40ug Lane 3: A549 Whole Cell Lysate at 40ug Lane 4: NEURO Whole Cell Lysate at 40ug Predicted bind size: 70KD Observed bind size: 70KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- SLC6A4 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti- SLC6A4 Picoband antibody, Western blotting All lanes: Anti SLC6A4  at 0.5ug/ml Lane 1: A549 Whole Cell Lysate at 40ug Lane 2: MM231 Whole Cell Lysate at 40ug Lane 3: HELA Whole Cell Lysate at 40ug Lane 4: 22RV1 Whole Cell Lysate at 40ug Predicted bind size: 70KD Observed bind size: 95KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat spleen tissue labeled with Anti-5-HTT/SLC6A4 Polyclonal Antibody, Unconjugated (ABIN735983) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded mouse embryo labeled with Anti-5-HTT/SLC6A4 Polyclonal Antibody, Unconjugated (ABIN735983) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$358.02
Details
Guinea Pig Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details

SLC6A4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies

  1. Human Polyclonal SLC6A4 Primary Antibody for IEM, ICC - ABIN617913 : Sur, Betz, Schloss: Localization of the serotonin transporter in rat spinal cord. in The European journal of neuroscience 1997 (PubMed)
    Show all 60 Pubmed References

  2. Human Polyclonal SLC6A4 Primary Antibody for IF (p), IHC (p) - ABIN735983 : Wang, Liu, Wang, Bai, Zhang, Sun, Wang: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. in Human & experimental toxicology 2013 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal SLC6A4 Primary Antibody for ELISA, WB - ABIN250555 : Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004 (PubMed)

More Antibodies against Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  2. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Antibodies) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Adrenal glands from wild-type mice contained 5-HT (show DDC Antibodies) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (show HTR1A Antibodies) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (show DDC Antibodies) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  2. These data suggest that correlated expression of Slc6a4 and Htr4 (show HTR4 Antibodies) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Antibodies).

  3. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  4. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  5. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  6. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (show DDC Antibodies) contributions of drug actions in vivo.

  7. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

  8. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (show GUSB Antibodies) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (show GUSB Antibodies).

  9. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (show CASP3 Antibodies) independent pathway by terminating the 5-HT (show DDC Antibodies) signaling.

  10. Variant Ala56-expressing mice display GI defects that resemble those seen in mice lacking neuronal 5-HT (show DDC Antibodies). These defects included enteric nervous system hypoplasia, slow GI transit, diminished peristaltic reflex activity, and proliferation of crypt epithelial cells.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Antibodies) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Rhesus monkeys carrying the short rh5 (show RHO Antibodies)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Antibodies) site is found in animals possessing this polymorphism.

  5. We find that the short allele of the rh5 (show RHO Antibodies)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  6. rh5 (show RHO Antibodies)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  8. carriers of the low-expressing rh5 (show RHO Antibodies)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  9. evidence that the short allelic variant in rh5 (show RHO Antibodies)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. the allelic distribution of solute carrier family-6 member-4 promoter region in Turkish athletes, is reported.

  2. Both a genetic (5-HTTLPR) and cognitive (ruminative thinking) stress vulnerability may mutually increase the risk for stress-related abnormal eating patterns.

  3. Overall, this investigation found evidence to suggest that 5-HTTLPR genotype affects the association of age and verbal episodic memory for males and females differently, with the predicted negative effect of S carriage present in males but not females.

  4. The low expressing 5-HTTLPR genotype group (SA/SA genotype) is twice as likely to have a history of concussion compared to other genotypes.

  5. Putatively detrimental effects of childhood trauma exposure on adult BDNF (show BDNF Antibodies) serum levels are influenced by 5-HTTLPR genotype in patients affected by bipolar disorder.

  6. Increased attachment security from 4 to 6 forecasts increases in emotion regulation from 6 to 8 and decreased attachment security forecasts decreases in emotion regulation among the 5-HTTLPR short-allele homozygotes.

  7. In summary, our results suggest that, by genetic association, the mu-opioid receptor (show OPRM1 Antibodies) interacts with serotonin transporter and serotonin 1A receptor to modulate exercise-induced hypoalgesia in fibromyalgia.

  8. This study demonstrated that youth who attended away from angry faces and were homozygous for the S allele of the 5-HTTLPR polymorphism were more likely to experience a depressive episode onset across 18-months.

  9. Our findings demonstrate that stressful family relationships not only initiate stress processes over the early life course, but also sensitize youth to stressors, and that 5-HTTLPR polymorphism interacts with stressful life experiences to predict heightened disease risk.

  10. The results suggest a potential role of the 5-HTTLPR in self-reported everyday task planning and monitoring.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Antigen Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • Serotonin transporter (SerT) antibody
  • solute carrier family 6 member 4 (SLC6A4) antibody
  • huntingtin (LOC100540532) antibody
  • solute carrier family 6 member 4 (slc6a4) antibody
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4) antibody
  • solute carrier family 6 member 4 (Slc6a4) antibody
  • 5-HTT antibody
  • 5-HTTLPR antibody
  • 5HTT antibody
  • AI323329 antibody
  • CG4545 antibody
  • Dmel\\CG4545 antibody
  • DmSerT antibody
  • dsert antibody
  • dSERT1 antibody
  • hSERT antibody
  • Htt antibody
  • OCD1 antibody
  • Sert antibody
  • SERT1 antibody
  • SLC6A4 antibody

Protein level used designations for SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPECIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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