Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies (108) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A4 6532 P31645
SLC6A4 15567 Q60857
SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg Log in to see 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
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Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$724.89
Details

SLC6A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins

  1. Human SLC6A4 Protein expressed in HEK-293 Cells - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaction Partners

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. results showing strong associations of childhood neglect and abuse and significant effects of the low-expressing alleles (S; L G ) of 5-HTTLPR with alexithymia.

  2. Alcohol use may be positively related, at least cross-sectionally, to depressive symptoms in female carriers of the 5-HTTLPR S allele, and indicate that moderators such as SLC6A4 genotype and sex need to be taken into account when examining associations between depressive symptoms and drinking behavior.

  3. The SERT gene promoter SNP rs25531 was associated with the cancer-related fatigue in patients with colon and rectal cancer

  4. No differences were found between murderers and thieves either concerning 5HTTLPR and 5-HT2C genotypes or concerning psychological measures. Comparison of polymorphism distribution between groups of prisoners and controls revealed highly significant associations of 5HTTLPR and 5-HTR2C (rs6318) gene polymorphisms with being convicted for criminal behavior.

  5. Significant association was observed between the S/S genotype of the SLC6A4 polymorphism and globus pharyngeus, suggesting that SLC6A4 is a potential candidate gene involved in the pathogenesis of globus pharyngeus.

  6. Association of SLC6A4 variants with familial form of OCD.

  7. 5-HTTLPR genotype was associated with traffic behaviour: The S'-allele carriers had significantly lower odds for speeding offences and traffic accidents. The lower prevalence of S'-allele carriers among those who had committed speeding offences was statistically significant in females, while the lower prevalence of having been involved in a traffic accident was rather observed in males.

  8. In the present study we systematically investigated the contribution of SNPs toward Social anxiety disorder by performing genotyping of 24 SNPs that have been reported previously in SAD or other psychiatric disorders. This showed an association between rs140701 at SLC6A4 and SAD, especially in Social anxiety disorder patients without panic disorder.

  9. Functional network-based phenotype links genetic variation in 5-HTTLPR to emotion regulation.

  10. These findings indicate that TPH1 (show TPH1 Proteins), TPH2 (show TDO2 Proteins), and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities.

  2. NOD2 could play a role in intestinal pathophysiology not only through its inherent innate immune role but also due to its interaction with other receptors as TLR2 and the modulation of the intestinal serotonergic system decreasing SERT activity and expression.

  3. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (show NDN Proteins)-knockout pups.

  4. Adrenal glands from wild-type mice contained 5-HT (show DDC Proteins) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (show HTR1A Proteins) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (show DDC Proteins) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  5. These data suggest that correlated expression of Slc6a4 and Htr4 (show HTR4 Proteins) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Proteins).

  6. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  7. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  8. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  9. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (show DDC Proteins) contributions of drug actions in vivo.

  10. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

  2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Proteins) storage, and potentially for function of dSERT.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Rhesus monkeys carrying the short rh5 (show RHO Proteins)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Proteins) site is found in animals possessing this polymorphism.

  5. We find that the short allele of the rh5 (show RHO Proteins)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  6. rh5 (show RHO Proteins)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  8. carriers of the low-expressing rh5 (show RHO Proteins)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  9. evidence that the short allelic variant in rh5 (show RHO Proteins)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Proteins) binding.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • solute carrier family 6 member 4 (SLC6A4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 member 4 (Slc6a4)
  • Serotonin transporter (SerT)
  • huntingtin (LOC100540532)
  • solute carrier family 6 member 4 (slc6a4)
  • solute carrier family 6 (neurotransmitter transporter), member 4a (slc6a4a)
  • 5-HTT protein
  • 5-HTTLPR protein
  • 5HTT protein
  • AI323329 protein
  • CG4545 protein
  • Dmel\\CG4545 protein
  • DmSerT protein
  • dsert protein
  • dSERT1 protein
  • hSERT protein
  • Htt protein
  • OCD1 protein
  • Sert protein
  • SERT1 protein
  • SLC6A4 protein

Protein level used designations for SLC6A4

5-hydroxytryptamine (serotonin) transporter , 5-hydroxytryptamine transporter , 5HT transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , solute carrier family 6 member 4 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , serotonin transporter , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , plasma membrane transporter for serotonin reuptake , transmembrane 5-HT transporter , sodium-dependent serotonin transporter-like , huntingtin , serotnin transporter , serotonin transporter a , serta , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A

GENE ID SPECIES
6532 Homo sapiens
15567 Mus musculus
25553 Rattus norvegicus
37895 Drosophila melanogaster
443491 Ovis aries
574140 Macaca mulatta
282365 Bos taurus
404747 Gallus gallus
468201 Pan troglodytes
100135619 Cavia porcellus
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
491184 Canis lupus familiaris
664719 Danio rerio
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