Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins (SLC6A4)

SLC6A4 encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Additionally we are shipping Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Antibodies (107) and Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC6A4 15567 Q60857
SLC6A4 6532 P31645
SLC6A4 25553 P31652
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Top Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
$814.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human GST tag,S tag,His tag 100 μg Log in to see 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$653.82
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Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$724.89
Details

SLC6A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , ,
, , ,
Rat (Rattus)

Top referenced Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 Proteins

  1. Human SLC6A4 Protein expressed in HEK-293 Cells - ABIN2732177 : Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour. in Neurotoxicology 2015 (PubMed)

More Proteins for Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. show that dSERT mutant animals exhibit an increased survival rate in stress conditions, increased basal motor behavior, and decreased levels in an anxiety-related parameter, centrophobism

  2. Data suggest that functional differences between human, and Drosophila melanogaster, and Caenorhabditis elegans serotonin transporters (SERT) in recognition of MDMA (3,4-methylenedioxy-methamphetamine, "ecstasy") as substrate are due to a single amino acid in transmembrane domain 10 (Glu394 in hSERT; Asn484 in dmSERT; Asp517 in ceSERT).

  3. These data suggest that a small number of neurons selectively express factor(s) required for 5-HT (show DDC Proteins) storage, and potentially for function of dSERT.

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Overall, these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin (show NDN Proteins)-knockout pups.

  2. Adrenal glands from wild-type mice contained 5-HT (show DDC Proteins) at approximately 750 fold lower abundance than adrenaline, and in SERT(-/-) mice this was reduced by approximately 80% with no change in catecholamines. SERT modulated the ability of 5-HT1A (show HTR1A Proteins) receptors to inhibit exocytosis. Spike charge and kinetics were not altered by 5-HT (show DDC Proteins) receptors but were reduced in SERT(-/-) cells compared to wild-type cells.

  3. These data suggest that correlated expression of Slc6a4 and Htr4 (show HTR4 Proteins) likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut (show GUSB Proteins).

  4. Data show that inhibitors of the serotonin reuptake transporter (SERT) were potent inhibitors of mouse breast tumor-initiating cells (BTIC) activity as determined by functional sphere-forming assays.

  5. genetic and pharmacological manipulations of this SERT function could illuminate the fundamental genetic programming of cortex-specific maps and biological roles of temporal-specific cortical topographic gene expression in normal development and mental disorders

  6. Findings indicate that maternal serotonin transporter function impacts offspring placental serotonin levels, forebrain serotonin levels, and neurodevelopment.

  7. These studies provide definitive support for an essential role of SERT antagonism in the acute and chronic actions of two commonly used SSRIs in these tests, and reinforce the utility of the SERT Met172 model for isolating SERT/5-HT (show DDC Proteins) contributions of drug actions in vivo.

  8. Study investigated the effect of environmental enrichment on approach-avoidance, depression-like, and sensorimotor gating behaviours 5-HTT knock-out (KO) mice. Environmental enrichment restores the abnormal innate anxiety but not the increased depression-like behaviour of 5-HTT KO mice.

  9. SERT mutant animals learned the auditory and visual tasks comparably to WT littermates, they failed to show behavioral gains under multisensory conditions. These results provide the first behavioral evidence of multisensory deficits in a genetic mouse model related to ASD (show GUSB Proteins) and implicate the serotonin system in multisensory processing and in the multisensory changes seen in ASD (show GUSB Proteins).

  10. SERT protects trophoblast cells against apoptotic cell death in caspase-3 (show CASP3 Proteins) independent pathway by terminating the 5-HT (show DDC Proteins) signaling.

Cow (Bovine) Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. This paper contains kinetics data of serotonin receptor (show HTR1B Proteins) binding.

Rhesus Monkey Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. Rhesus monkeys carrying the short rh5 (show RHO Proteins)-HTTLPR allele have less optimal neonatal sensory scores than monkeys homozygous for the long allele.

  2. An effect of social status is detected on 5HTT levels in the developing orbitofrontal cortex partly influenced by exposure to the social stress of subordination.

  3. Study reports evidence for selection at the SLC6A4 gene and epigenetic reorganization according to genotype, stress, and age.

  4. A significant 5-HTTLPR effect on receptor binding at the 5-HT1A receptor (show HTR1A Proteins) site is found in animals possessing this polymorphism.

  5. We find that the short allele of the rh5 (show RHO Proteins)-HTTLPR is associated with reduced surface SERT binding, which is correlated on an individual basis with serotonin uptake rates.

  6. rh5 (show RHO Proteins)-HTTLPR allele modifies the effects of maternal temperament on offspring's personality development.

  7. short allele of the serotonin transporter may increase reactivity to repeated, chronic stressors, leaving them more vulnerable to affective psychopathology, with females particularly vulnerable.

  8. carriers of the low-expressing rh5 (show RHO Proteins)-HTTLPR alleles exhibited higher mean 5-HTT CpG methylation, which was associated with lower PBMC 5-HTT expression.

  9. evidence that the short allelic variant in rh5 (show RHO Proteins)-HTTLPR accounts for increased occurrence of abusive parenting; in mothers and infants short allele associated with higher basal cortisol levels and greater hormonal stress responses in infants

  10. this study provided a basis for quantitative analysis of SERT gene expression under effects of host and environmental factors

Human Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) interaction partners

  1. 5-HTTLPR genotype was associated with traffic behaviour: The S'-allele carriers had significantly lower odds for speeding offences and traffic accidents. The lower prevalence of S'-allele carriers among those who had committed speeding offences was statistically significant in females, while the lower prevalence of having been involved in a traffic accident was rather observed in males.

  2. In the present study we systematically investigated the contribution of SNPs toward Social anxiety disorder by performing genotyping of 24 SNPs that have been reported previously in SAD or other psychiatric disorders. This showed an association between rs140701 at SLC6A4 and SAD, especially in Social anxiety disorder patients without panic disorder.

  3. Functional network-based phenotype links genetic variation in 5-HTTLPR to emotion regulation.

  4. These findings indicate that TPH1 (show TPH1 Proteins), TPH2 (show TDO2 Proteins), and SLC6A4 variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.

  5. This study found that the SLC6A4 hyper-methylation and hypo-expression was found in healthy subjects with childhood trauma.

  6. resilience fully mediated the association between the S 5-HTTLPR allele and depression in the medically ill.

  7. Study applied graph theory analysis on resting-state fMRI of 120 women selected based on neuroticism score, & genotyped 2 polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (show COMT Proteins) (rs4680-rs165599; COMT (show COMT Proteins) risk group and COMT (show COMT Proteins) non-risk group). For the 5-HTTLPR polymorphism, found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes.

  8. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in 5-HTTLPR homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome.

  9. Pilot study demonstrated an increase in the SLC6A4 promoter DNA methylation (show HELLS Proteins) levels in the saliva (show RAG1AP1 Proteins) of children and adolescents with obsessive-compulsive disorder. DNA methylation (show HELLS Proteins) provides one important epigenetic mechanism through which environmental influences can affect psychiatric disease risk.

  10. genetic association studies in population in Spain: Data suggest genetic polymorphisms in SLC6A4 promoter region are associated with ability to control food intake in overweight/obese subjects while in weight loss programs; SLC6A4 promoter polymorphisms interact with emotional eating to modulate weight loss. The biggest challenge for losing weight is the ability to control the amount of food eaten.

Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4) Protein Profile

Protein Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene names and symbols associated with SLC6A4

  • Serotonin transporter (SerT)
  • solute carrier family 6 member 4 (SLC6A4)
  • huntingtin (LOC100540532)
  • solute carrier family 6 member 4 (slc6a4)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (Slc6a4)
  • solute carrier family 6 member 4 (Slc6a4)
  • 5-HTT protein
  • 5-HTTLPR protein
  • 5HTT protein
  • AI323329 protein
  • CG4545 protein
  • Dmel\\CG4545 protein
  • DmSerT protein
  • dsert protein
  • dSERT1 protein
  • hSERT protein
  • Htt protein
  • OCD1 protein
  • Sert protein
  • SERT1 protein
  • SLC6A4 protein

Protein level used designations for SLC6A4

serotonin transporter , CG4545-PA , SerT-PA , drosophila serotonin transporter , cocaine-sensitive serotonin transporter , sodium-dependent serotonin transporter , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , solute carrier family 6 member 4 , sodium-dependent serotonin transporter-like , huntingtin , plasma membrane transporter for serotonin reuptake , 5-hydroxytryptamine (serotonin) transporter , 5HT transporter , 5HTT , Sodium-dependent serotonin transporter (5HT transporter) (5HTT) , transmembrane 5-HT transporter , 5-hydroxytryptamine transporter , Na+/Cl- dependent serotonin transporter , serotonin transporter 1 , Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter) , solute carrier family 6, member 4 , serotnin transporter

GENE ID SPECIES
37895 Drosophila melanogaster
404747 Gallus gallus
468201 Pan troglodytes
100340600 Oryctolagus cuniculus
100396167 Callithrix jacchus
100435954 Pongo abelii
100540532 Meleagris gallopavo
100562250 Anolis carolinensis
100596376 Nomascus leucogenys
443491 Ovis aries
15567 Mus musculus
282365 Bos taurus
100135619 Cavia porcellus
574140 Macaca mulatta
6532 Homo sapiens
25553 Rattus norvegicus
491184 Canis lupus familiaris
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