SLC6A4 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2732177

Product Details

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SLC6A4 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human SLC6A4 / SERT protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Savy, Fitchett, McQuade, Gartside, Morris, Blain, Judge: "Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour." in: Neurotoxicology, Vol. 50, pp. 149-56, (2015) (PubMed).

Target Details

Target: SLC6A4 (Solute Carrier Family 6 (Neurotransmitter Transporter, serotonin), Member 4 (SLC6A4))

Alternative Name: Slc6a4,sert (SLC6A4 Products)

Synonyms: 5-HTT Protein, 5-HTTLPR Protein, 5HTT Protein, HTT Protein, OCD1 Protein, SERT Protein, SERT1 Protein, hSERT Protein, AI323329 Protein, Htt Protein, Sert Protein, CG4545 Protein, DmSERT Protein, DmSerT Protein, Dmel\\CG4545 Protein, dSERT Protein, dSERT1 Protein, dSerT Protein, dSert Protein, dsert Protein, SLC6A4 Protein, solute carrier family 6 member 4 Protein, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Protein, Serotonin transporter Protein, huntingtin Protein, solute carrier family 6 (neurotransmitter transporter), member 4b Protein, solute carrier family 6 (neurotransmitter transporter), member 4a Protein, SLC6A4 Protein, Slc6a4 Protein, SerT Protein, LOC100540532 Protein, slc6a4 Protein, slc6a4b Protein, slc6a4a Protein

Background: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Molecular Weight: 70.1 kDa

NCBI Accession: NP_001036