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SLC8A3 encodes a member of the sodium/calcium exchanger integral membrane protein family. Additionally we are shipping Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 3 Proteins (5) and many more products for this protein.
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Cow (Bovine) Polyclonal SLC8A3 Primary Antibody for WB - ABIN2781702
Pulina, Rizzuto, Brini, Carafoli: Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. in The Journal of biological chemistry 2006
Show all 2 Pubmed References
These results...suggest that cells can use a dynamic Ca(2 (show CA2 Antibodies)+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle
Structure-Dynamic Coupling Through Ca(2 (show CA2 Antibodies)+)-Binding Regulatory Domains of Mammalian NCX (show TLX2 Antibodies) Isoform/Splice Variants
stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus.
In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA (show PRTN3 Antibodies)-positive rheumatoid arthritis at a genome-wide level of significance.
Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain.
NCX1 (show SLC8A1 Antibodies) and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy.
NCX (show TLX2 Antibodies) isoforms (NCX2 (show SLC8A2 Antibodies), NCX3) contribute to mitochondrial Na(+)/Ca(2 (show CA2 Antibodies)+) exchange in human DAergic neurons and may act downstream of PINK1 (show PINK1 Antibodies) in the prevention of neurodegeneration by m[Ca(2 (show CA2 Antibodies)+)] accumulation.
the large cytosolic loop of NCX1 (show SLC8A1 Antibodies), NCX2 (show SLC8A2 Antibodies), and NCX3 is involved in acquisition of immunosuppressive drug specificity
Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 (show SLC8A1 Antibodies) and NCX3, but not NCX2 (show SLC8A2 Antibodies), were divergently modulated during OPC differentiation into oligodendrocyte.
human macrophages and monocytes express NCX1 (show SLC8A1 Antibodies) and NCX3 that operate in a bidirectional manner to restore [Ca(2 (show CA2 Antibodies)+)](i) to generate Ca(2 (show CA2 Antibodies)+) signals and to induce TNF-alpha (show TNF Antibodies) production.
NCX2 (show SLC8A2 Antibodies) and NCX3 protein and mRNA levels are relatively reduced in hippocampal CA1 (show CA1 Antibodies) of APP23 and APP (show APP Antibodies)-KI mice. Likewise, NCX2 (show SLC8A2 Antibodies)(+/-) or NCX3(+/-) mice exhibited impaired hippocampal LTP (show SCP2 Antibodies) and memory-related behaviors. Moreover, relative to controls, calcium/calmodulin-dependent protein kinase II (CaMKII (show CAMK2 Antibodies)) autophosphorylation significantly decreased in NCX2 (show SLC8A2 Antibodies)(+/-) mouse hippocampus but increased in hippocampus of NCX3(+/-) mice.
This study demonstrate that knocking-out NCX3 impairs oligodendrocyte response and worsens clinical symptoms in EAE without altering the immune T-cell population.
Demonstrate that NCX3 genetic deletion protects against ziram-induced neurotoxicity and suggest NCX3 and its downstream molecular pathways as key factors involved in ziram toxicity.
NCX3 regulates mitochondrial calcium handling from the outer mitochondrial membrane through an AKAP121 (show AKAP1 Antibodies)-anchored signaling complex.
Function and regulation of the Na+-Ca2+ exchanger (show SLC8A1 Antibodies) NCX3 splice variants in brain and skeletal muscle.
the use of genetic-modified mice for NCX1 (show SLC8A1 Antibodies), NCX2 (show SLC8A2 Antibodies), and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX (show SLC8A1 Antibodies) in CNS
the solution structure of NCX3 calcium binding domain 2B
calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation.
Results show that glucocorticoid treatment blunts LPS (show TLR4 Antibodies)-induced increase in [Ca(2 (show CA2 Antibodies)+)](i) in dendritic cells by increasing expression and activity of Na(+)/Ca(2 (show CA2 Antibodies)+) exchanger NCX3.
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
solute carrier family 8 (sodium-calcium exchanger), member 3
, solute carrier family 8 member 3
, solute carrier family 8 (sodium/calcium exchanger), member 3
, sodium/calcium exchanger 3-like
, Na(+)/Ca(2+)-exchange protein 3
, Na+/Ca2+ exchanger 3
, sodium/calcium exchanger 3
, sodium/calcium exchanger SLC8A3
, sodium-calcium exchanger