Sorting Nexin 9 (SNX9) ELISA Kits

Xenopus laevis Sorting Nexin 9 (SNX9) interaction partners

1. Sorting nexin 9 (Snx9) can be implicated as a specific adaptor that replaces toca-1 to mobilize neural Wiskott-Aldrich syndrome protein and the Arp2/3 complex.

Human Sorting Nexin 9 (SNX9) interaction partners

1. SNX9 knockdown revealed a nonredundant effect on overall ADAM9 protein levels, resulting in increased ADAM9 levels at the cell surface

2. SNX9 assembles into ring-like structures around the endocytic vesicles

3. In conclusion, the authors identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease.

4. The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior.

5. reduced levels of SNX9 were observed in blood samples from colorectal cancer patients, emphasizing the feasibility of its use as a diagnostic and prognostic biomarker sensing the host's immune status and inflammatory stage.

6. this study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrin-mediated endocytosis.

7. SNX9 and CHC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association.

8. The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis.

9. study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions.

10. Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9.

11. The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9.

12. SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site.

13. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation

14. SNX9 may function to assist AP-2 in its role at the plasma membrane.

15. SNX9 may be recruited together with dynamin-2 and become co-assembled with AP-2 and clathrin at the plasma membrane

16. SNX9-dependent recruitment of Dyn2 to the membrane is regulated by an interaction between SNX9 and aldolase

17. SNX9 is required for efficient clathrin-mediated endocytosis and suggest that it functions to regulate dynamin activity

18. Data show that in the presence of SNX9, synaptojanin-1 is able to colocalize with distinct ACK1 containing vesicles.

19. Dimerization, which is mediated by the BAR domain, is essential for the intracellular function of SH3PX1.

20. identified sorting nexin 9 (SNX9) as a host cell enteropathogenic E. coli EspF binding partner protein, which binds EspF via its amino-terminal SH3 region

Mouse (Murine) Sorting Nexin 9 (SNX9) interaction partners

1. Snx9-deficient mice do not show defects in development as well as auditory function, suggesting that SNX9 is not essential for mice development and hearing