Sperm Associated Antigen 1 Proteins

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization.

Data Quality
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Type
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    Protein
Antigen
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Reactivity
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Application
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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6 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse (Murine)
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3136094
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3095660
$13,376.85
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 70 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1321052
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity ≥ 99 %
ReactivityHuman
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN4989596
$649.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source)
ReactivityHuman
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN6118303
$661.28
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2732486
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
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Sperm Associated Antigen 1 (SPAG1) Protein Profile

Protein Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Gene names and symbols associated with SPAG1

  • sperm associated antigen 1 (SPAG1) antibody
  • sperm associated antigen 1a (spag1a) antibody
  • sperm associated antigen 1 (CpipJ_CPIJ006297) antibody
  • sperm associated antigen 1 (spag1) antibody
  • sperm associated antigen 1 (Spag1) antibody
  • cb1089 antibody
  • HSD-3.8 antibody
  • MGC162178 antibody
  • SP75 antibody
  • TPIS antibody
  • wu:fj78g10 antibody

Protein level used designations for SPAG1

sperm associated antigen 1 , sperm-associated antigen 1 , TPR-containing protein involved in spermatogenesis , infertility-related sperm protein Spag-1 , tetratricopeptide repeat-containing protein , HSD-3.8

GENE ID SPECIES
420249 Gallus gallus
464314 Pan troglodytes
564953 Danio rerio
607063 Canis lupus familiaris
6038177 Culex quinquefasciatus
100038144 Xenopus (Silurana) tropicalis
6674 Homo sapiens
26942 Mus musculus
315033 Rattus norvegicus
530104 Bos taurus
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