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Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. Additionally we are shipping SGPP1 Kits (22) and SGPP1 Proteins (4) and many more products for this protein.
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Human Polyclonal SGPP1 Primary Antibody for WB - ABIN4894719
Dulneva, Lee, Oliver, Di Gleria, Kessler, Davies, Becker: The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum. in Human molecular genetics 2015
the sequential expression and localization of the endogenous S1P regulators SGPP-1 and SGPL-1 and highlight their contribution to the sphingolipid rheostat in inflammation.
The two gastric cancer cells transfected with pEF-SGPP1 exhibited a slower rate of growth with less adhesion. Thus, our findings provided evidence that SGPP1 may serve as a prognostic biomarker for patients with advanced gastric cancers.
Study has revealed miR-27a as a tumor suppressor and has identified SGPP1 and Smad2 as novel targets of miR-27a, linking to STAT3 for regulating cancer cell proliferation, apoptosis and migration in colorectal cancer.
The sphingolipid phosphatase SGPP1, an antagonist of sphingosine-1-phosphate signaling, is a target of miR-95 that promotes radiation resistance.
S1P is elevated in patients with IPF, correlates with the lung function and mediates EMT.
doxorubicin switches protective autophagy in SPP1-depleted cells to apoptosis by calpain-mediated Atg5 cleavage.
Under normal circumstances, the retinal vascular pericytes maintain pericyte-endothelial contacts and vascular barrier function through the secretion of sphingosine 1-phosphate.
SPP1 by regulating intracellular S1P homeostasis, can control the UPR and ER stress-induced autophagy.
sphingosine-1-phosphate phosphatase 1 plays roles in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
sphingosine-1-phosphate phosphatase 1 has a role in epidermal growth factor-induced chemotaxis
SPP-1 regulates ceramide levels in the ER and thus influences the anterograde membrane transport of both ceramide and proteins from the ER to the Golgi apparatus.
Sphingosine kinase 2, but not sphingosine kinase 1, acted in concert with SPP-1 to regulate recycling of sphingosine into ceramide.
Results show that Runx1 regulates glucocorticoid sensitivity in lymphoma cells and identify an established direct target gene, Sgpp1, as an integrator of sphingolipid metabolism and responses to glucocorticoids.
Data indicate that sphingosine-1-phosphate phosphatases 1 (Sgpp1) deficiency in keratinocytes causes sphingosine-1-phosphate (S1P) elevation and accelerates their differentiation.
regulation of sphingolipid metabolism and apoptosis by SPP1
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000
sphingosine-1-phosphate phosphatase 1
, sphingosine-1-phosphatase 1
, sphingosine-1-phosphate phosphohydrolase