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SKA3 encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. Additionally we are shipping and many more products for this protein.
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Study shows that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core outer kinetochore component, also show that this phosphorylation occurs specifically during mitosis and is required for the kinetochore localization of the Ska complex.
this report provides clear evidence that overexpression of the AURKA (show AURKA Antibodies), SKA3, and DSN1 (show DSN1 Antibodies) genes strongly correlates with the progression of colorectal adenomas to colorectal cancer
Kinetochores mature through Ska1 (show SKA1 Antibodies)/ska2 (show FAM33A Antibodies)/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint.
over-expression of GNL3 (show E2IG3 Antibodies) and SKA3 in the PC-3 (show PCSK1 Antibodies) human prostate cancer cell line decreased in vitro cell migration and invasion
The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1 (show SKA1 Antibodies), Ska2 (show FAM33A Antibodies), and Ska3.
Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments.
Ska3 functions to coordinate checkpoint signaling from the microtubule binding sites within a kinetochore by laterally linking the individual binding sites.
C13Orf3 (now termed Ska3) localizes to the spindle and kinetochore throughout mitosis and its depletion markedly delays anaphase transition.
These data identify C13orf3 (Ska3) as an important factor for metaphase to anaphase progression and highlight the potential of combined RNAi screening and protein localisation analyses.
RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment.
The Ska3 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants.
spindle and kinetochore-associated protein 3
, spindle and kinetochore associated complex subunit 3
, Spindle and kinetochore-associated protein RAMA1