anti-Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) Antibodies

Zebrafish Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) interaction partners

1. The present study demonstrates the possible role of Spred-2 signalling in cell proliferative phase during the neural repair in the injured zebrafish brain

Human Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) interaction partners

1. Our findings show that miR (show MLXIP Antibodies)-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC (show FAM126A Antibodies)) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR (show MLXIP Antibodies)-487a as a potential prognostic marker or a potential therapeutic target against HCC (show FAM126A Antibodies).

2. data indicate that Spred2 induces tumor cell death in an autophagy-dependent manner.

3. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

4. Spred2 was involved in erythroid differentiation of chronic myeloid leukemia (show BCL11A Antibodies) cells and participated in imatinib induced erythroid differentiation partly through ERK (show EPHB2 Antibodies) signaling.

5. Downregulation of SPRED2 mRNA is associated with prostate cancer.

6. Data present that galectin-1 (show LGALS1 Antibodies), ataxin-3 (show ATXN3 Antibodies) and sprouty-related EVH1 domain-containing protein 2 (SPRED2) may be associated with the progression and development of Down syndrome.

7. Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with the p85 subunit of phosphatidylinositol 3-kinase.

8. the knockdown of Spred2 markedly enhanced tumor growth in vivo.

9. Sprouty and Spred proteins are negative regulators of the ERK/Elk-1 (show ELK1 Antibodies) pathway activation induced not only by growth-factors, but also by reactive lipidic mediators.

10. data in the present study suggests that Spred2 is a regulator of TGF-beta1 (show TGFB1 Antibodies)-induced malignance in transformed keratinocytes

Mouse (Murine) Sprouty-Related, EVH1 Domain Containing 2 (SPRED2) interaction partners

1. Spred2 plays an important role in the regulation of colonic epithelial cell proliferation and inflammation by potentially down-regulating the activation of ERK (show EPHB2 Antibodies).

2. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

3. SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (show MAPK1 Antibodies) signaling pathway in pluripotent cells

4. Spred-2 controls the development of lipopolysaccharide-induced lung inflammation.

5. Spred-2 negatively regulates APAP-hepatotoxicity under the control of Kupffer cells and NK cells.

6. Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.

7. Data show that both SPRED1 (show SPRED1 Antibodies) and SPRED2 inhibit the ability of DYRK1A (show DYRK1A Antibodies) to phosphorylate its substrates.

8. SPRED2 is likely involved in the regulation of dynamic developmental processes.

9. Spred-2 functions as a negative regulator of aorta-gonad-mesonephros hematopoiesis by inhibiting hematopoietic cytokine signaling.

10. These data suggest that Spreds are key regulators of RhoA (show RHOA Antibodies)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.