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SCAI encodes a regulator of cell migration. Additionally we are shipping and many more products for this protein.
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High SCAI expression is associated with gastric, prostate, and colorectal cancer.
Whole-genome sequencing and confirmatory Sanger sequencing of junction PCR products were used to show that in each of the 5 cases, the SMAD4 processed gene was integrated at the same position on chromosome 9, located within the last intron of the SCAI gene
Data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2.
miR-625-3p exerts its oncogenic functions through regulation of SCAI/E-cadherin/MMP-9 pathways
miR-1228 promoted breast cancer proliferation, invasion and migration was mediated by MOAP1 and SCAI.
Downregulation of SCAI enhances glioma cell invasion and cancer stem cell like phenotype.Downregulation of SCAI activates the Wnt/beta-catenin signaling.
SCAI is a specific interaction partner for KMD3B.
SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis.
Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin
SCAI (suppressor of cancer cell invasion) is identified as a 53BP1-interacting chromatin-associated protein that promotes the functionality of several DNA double-strand breaks repair pathways in mammalian cells.
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described.
suppressor of cancer cell invasion
, protein SCAI
, suppressor of cancer cell invasion protein