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TSC22D1 encodes a member of the TSC22 domain family of leucine zipper transcription factors. Additionally we are shipping TSC22 Domain Family, Member 1 Antibodies (79) and TSC22 Domain Family, Member 1 Kits (9) and many more products for this protein.
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TSC-22 acts as a tumor suppressor by safeguarding p53 (show TP53 Proteins) from poly-ubiquitination mediated-degradation.
we report that induced Tsc-22 leads to enhancement of TGF-beta (show TGFB1 Proteins)-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant
Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene (show RAB1A Proteins)-induced cellular senescence.
Results support role of TSC22D1 as an enhancer of CNP (show CNP Proteins) transcription and suggest that TGF-beta (show TGFB1 Proteins)-induced upregulation of CNP (show CNP Proteins) expression in smooth muscle may be mediated in part by increased transcription of TSC22D1.
Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells
TSC-22 is an important downstream component of PPARgamma (show PPARG Proteins) and TGF-beta (show TGFB1 Proteins) signaling during intestinal epithelial cell differentiation
findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy
Upregulation of TSC-22 mRNA by TGF-beta 1 (show TGFB1 Proteins) is achieved by mRNA stabilization.
Tsc-22 modulates the TGF-beta (show TGFB1 Proteins)-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 (show SMAD3 Proteins) and Smad4 (show SMAD4 Proteins). It has effect on cellular differentiation
expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate
High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma.
These results suggested that TSC-22 could counteract the protective effect of GILZ (show TSC22D3 Proteins) on IL-2 (show IL2 Proteins)-deprivation-induced apoptosis.
Fat4 and Tsc22d1 are likely candidate genes to influence formation of spontaneous pulmonary adenoma in aging male and female mice, respectively.
post-transcriptional regulation of Tsc-22 mediated through Ybx1 (show YBX1 Proteins), a miR (show MLXIP Proteins)-216a target, plays a key role in TGF-beta (show TGFB1 Proteins)-induced Col1a2 (show COL1A2 Proteins) in MC related to the pathogenesis of diabetic nephropathy
novel opposing functions of the two mammalian TSC (show SLC12A3 Proteins)-22D1 isoforms in cell survival and proliferation, and establish the TSC (show SLC12A3 Proteins)-22D1 isoform 2 as a potential regulator of cell death during mammary gland involution
Analysis of the regulation of Tgf beta1i4 by Foxc1 (show FOXC1 Proteins) in mesenchymal cells isolated from the periocular region revealed that Foxc1 (show FOXC1 Proteins) negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1 (show TGFB1 Proteins).
TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.
XTSC-22 (TSC-22) is required for cell movement during gastrulation though cell cycle regulation.
Analysis of deletion mutants of XTSC-22 revealed that nuclear localization of the N-terminal TSC (show TESC Proteins)-box is necessary for cell cycle inhibition by XTSC-22.
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
TGFB-stimulated clone 22 homolog
, TGFbeta-stimulated clone 22
, TSC22 domain family protein 1
, cerebral protein 2
, regulatory protein TSC-22
, transcriptional regulator TSC-22
, transforming growth factor beta-1-induced transcript 4 protein
, transforming growth factor beta-stimulated protein TSC-22
, Tgfb-stimulated clone 22 homolog
, Tsc22-related inducible leucine zipper 1b
, regulatory protein Tsc22
, transforming growth factor beta 1 induced transcript 4
, Transforming growth factor beta stimulated clone 22
, TSC22 domain family, member 1
, short tandem repeat locus PEZ20 variant 19
, TGFb stimulated clone 22 (TSC-22)
, TSC22 domain family 1