TSC22 Domain Family, Member 3 Proteins (TSC22D3)

The protein encoded by TSC22D3 shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators.

list all proteins Gene Name GeneID UniProt
Human TSC22D3 TSC22D3 1831 Q99576
Mouse TSC22D3 TSC22D3 14605 Q9Z2S7
Rat TSC22D3 TSC22D3 83514 Q9EQZ1
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Top TSC22D3 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$669.00
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$685.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$492.31
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,102.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,280.67
Details
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$2,280.67
Details

More Proteins for TSC22 Domain Family, Member 3 (TSC22D3) Interaction Partners

Zebrafish TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. Zebrafish tsc22d3 is a ventralizing gene and plays a role in early embryogenesis

Human TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. The mRNA expression of GILZ was significantly correlated with Systemic Lupus Erythematosus Disease Activity Index score.

  2. We propose a novel role of GILZ in contributing to corticoid-induced leptin (show LEP Proteins) and leptin receptor (show LEPR Proteins) expression in osteoarthritis synovial fibroblasts

  3. TSC22D3 gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.

  4. Overall, these results suggest that GILZ antagonizes the pro-inflammatory effects of TNFa (show TNF Proteins) in human adipocytes, and its downregulation in obesity may contribute to adipose inflammation and dysregulated adipokine production, and thereby systemic metabolism.

  5. Under endoplasmic reticulum stress conditions, overexpression of GILZ significantly reduced activation of mitochondrial pathway of apoptosis by maintaining Bcl-xl (show BCL2L1 Proteins) level. GILZ protein affects the unfolded protein response signaling shifting the balance towards pro-survival signals as judged by down-regulation of CHOP (show DDIT3 Proteins), ATF4 (show ATF4 Proteins), XBP1s mRNA and increase in GRP78 (show HSPA5 Proteins) protein level.

  6. results reveal GILZ to be a new actor in apoptosis regulation in neutrophil-like cells involving JNK (show MAPK8 Proteins) and Mcl-1 (show MCL1 Proteins).

  7. GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus.

  8. our data suggest that GILZ is a key regulator of macrophage functions.

  9. L-GILZ stabilizes p53 (show TP53 Proteins) proteins by decreasing p53 (show TP53 Proteins) ubiquitination and increasing MDM2 (show MDM2 Proteins) ubiquitination.

  10. The N-terminal part of L-GILZ protein is responsible for Ras/L-GILZ protein-to-protein interaction, important for the control of proliferation rate of spermatogonia.

Mouse (Murine) TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. In GILZ-Tg mice, the severity of IMQ-induced psoriasis-like skin lesions and induction of human-psoriasis-related cytokines (Il-17 (show IL17A Proteins), Il-22 (show IL22 Proteins), Il-23 (show IL23A Proteins), Il-6 (show IL6 Proteins), S100a8 (show S100A8 Proteins)/a9, and Stat3 (show STAT3 Proteins)) was significantly more pronounced relative to GILZ-Wt mice. Skin-specific over-activation of TGF-beta1 (show TGFB1 Proteins)-mediated signaling occurred via SMAD2 (show SMAD2 Proteins)/3.

  2. Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A (show FOXO3 Proteins)-dependent quiescence of disseminated stem-like cells

  3. GILZ promotes potassium secretion by inhibiting sodium-chloride cotransporter (show SLC12A3 Proteins) and enhancing distal sodium delivery to the epithelial sodium channel.

  4. HuR (show ELAVL1 Proteins) overexpression led to increased GILZ protein levels but had no effect on GILZ mRNA expression.

  5. The present findings shed light on the role of GILZ in the mechanism of induction of Anxa1 (show ANXA1 Proteins) by GCs (show UGCG Proteins). As Anxa1 (show ANXA1 Proteins) is an important protein for the resolution of inflammatory response, GILZ may represent a new pharmacologic target for treatment of inflammatory diseases.

  6. Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss

  7. marked reduction in cardiac GILZ in association with increased Th-17 cells accompanied with marked disruption of mitochondrial membrane potential and increased apoptotic/necrotic cell death in hearts subjected to myocardial infarction

  8. results identify GILZ as an endogenous inhibitor of macropinocytosis in DCs, the action of which contributes to the fine-tuning of Ag cross-presentation.

  9. Obesity is associated with a downregulation of the Gr-Gilz axis in kupffer cells, which promotes liver inflammation.

  10. GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus.

TSC22D3 Protein Profile

Protein Summary

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with TSC22D3

  • TSC22 domain family member 3 L homeolog (tsc22d3.L)
  • TSC22 domain family, member 3 (tsc22d3)
  • TSC22 domain family member 3 (TSC22D3)
  • TSC22 domain family member 3 (tsc22d3)
  • TSC22 domain family, member 3 (Tsc22d3)
  • DIP protein
  • DSIP protein
  • Dsip1 protein
  • Dsipi protein
  • Gilz protein
  • hDIP protein
  • MGC53285 protein
  • Tilz3 protein
  • TSC-22R protein
  • TSC22D3 protein
  • zgc:65831 protein
  • zgc:77028 protein

Protein level used designations for TSC22D3

TSC22 domain family, member 3 , glucocorticoid-induced leucine zipper , TSC22 domain family protein 3 , gilz , glucocorticoid-induced leucine zipper protein , DSIP-immunoreactive leucine zipper protein , DSIP-immunoreactive peptide , TSC-22 related protein , TSC-22-like protein , TSC-22-related protein , delta sleep inducing peptide, immunoreactor , delta sleep-inducing peptide immunoreactor , TSC22 domain family 3 , TSC22-related inducible leucine zipper 3 , TSC22-related-inducible leucine zipper 3 , long glucocorticoid-induced leucine zipper protein , DIP protein , Glucocorticoid-induced leucine zipper protein , delta-sleep-inducing peptide

GENE ID SPECIES
379978 Xenopus laevis
393541 Danio rerio
492057 Canis lupus familiaris
702656 Macaca mulatta
739684 Pan troglodytes
768091 Gallus gallus
100125309 Bos taurus
100145088 Xenopus (Silurana) tropicalis
100227519 Taeniopygia guttata
100356656 Oryctolagus cuniculus
1831 Homo sapiens
14605 Mus musculus
83514 Rattus norvegicus
100517321 Sus scrofa
100171736 Pongo abelii
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