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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Kits (12) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins (5) and many more products for this protein.
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Human Polyclonal TNKS2 Primary Antibody for WB - ABIN450074
Sidorova, Zavalishina, Kurchashova, Korsakova, Nazhimov, Frank, Kuimov: Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue. in Cell and tissue research 2005
Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS (show TNKS Antibodies) enzyme activities.
Polymerization is required for Tankyrase to drive beta-catenin (show CTNNB1 Antibodies)-dependent transcription. The polymeric state supports PARP (show COL11A2 Antibodies) activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN (show AXIN1 Antibodies) binding.
These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.
High TNKS2 expression is associated with breast cancer.
The tumor suppressive activity of miR (show MLXIP Antibodies)-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin (show CTNNB1 Antibodies) signaling. Thus, miR (show MLXIP Antibodies)-490-3p may represent a potential therapeutic target for triple-negative breast cancer.
Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 Antibodies)/2 and tankyrase 1 (show TNKS Antibodies)/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling addicted tumors.
Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A Antibodies) with aberrant WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
TNKS2 is recruited to DNA lesions by MDC1 (show MDC1 Antibodies) and promotes homologous recombination in response to DNA double strand breaks.
The variability of genes encoding for TERF1 (show TERF1 Antibodies) and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.
Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP Antibodies) and Tyr (show TYR Antibodies)) in the hydrophobic region at the induced pocket of TNKS1 (show TNKS Antibodies)/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS (show TNKS Antibodies) proteins.
Tank1 (show TNKS Antibodies)/Tank2 inhibition aggravates kidney injury in the absence of CD2AP (show Cd2ap Antibodies).
a new function of RNF146 (show RNF146 Antibodies) and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT (show AMOT Antibodies) proteins at the apical membrane, is reported.
TNKS2 is required in insulin (show INS Antibodies)-stimulated glucose disposal.
Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.
Data show that Tnks1 (show TNKS Antibodies) and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 Antibodies) ligands.
inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.
Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.
tankyrase 2is essential but redundant for mouse embryonic development
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.
ADP-ribosyltransferase diphtheria toxin-like 6
, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
, poly [ADP-ribose] polymerase 5B
, tankyrase 2
, tankyrase II
, tankyrase-like protein
, tankyrase-related protein
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
, LOW QUALITY PROTEIN: tankyrase-2
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase L homeolog
, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog