anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Antibodies

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Kits (12) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNKS2 80351 Q9H2K2
TNKS2 74493 Q3UES3
TNKS2 309512  
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Top anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using Tankyrase 2, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. WB Image Sample (30 ug of whole cell lysate) A: A431 , B: Hela C: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated FACS, WB Tnks 2 Antibody (C-term) (ABIN651506) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the Tnks 2 antibody detected Tnks 2 protein (arrow). Tnks 2 Antibody (C-term) (ABIN651506) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Dog Goat Un-conjugated WB   0.1 mg Log in to see 4 to 8 Days
$462.00
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated WB Western Blot: TNKS2 Antibody [NBP1-36993] - HEK293 overexpressing TANK2 (lane 4) and TANK1 (lane 2) and probed with NBP1-36993 (mock transfection in first lane). Lane three is empty. Lower panel shows the same lysates probed for alpha-Actin to show protein levels. Primary incubation (0.5ug/ml) was overnight at 4C. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$488.73
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant TNKS2, Human. Used in DAB staining on fromalin fixed paraffin- embedded liver tissue 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$293.00
Details
Human Goat Un-conjugated WB   100 μg Log in to see 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 14 Days
$1,079.83
Details

Top referenced anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Antibodies

  1. Human Polyclonal TNKS2 Primary Antibody for WB - ABIN450074 : Sidorova, Zavalishina, Kurchashova, Korsakova, Nazhimov, Frank, Kuimov: Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue. in Cell and tissue research 2005 (PubMed)

More Antibodies against Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. CTIF was identified as a novel PARylation target of the TNKS2 in the centrosomal region of cells, which plays a role in the distribution of the centrosomal satellites.

  2. Either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere cohesion and maintain mitotic spindle integrity. Tankyrases are required for Notch2 to exit the plasma membrane and enter the nucleus to activate transcription.

  3. Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS enzyme activities.

  4. Polymerization is required for Tankyrase to drive beta-catenin-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN binding.

  5. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  6. High TNKS2 expression is associated with breast cancer.

  7. The tumor suppressive activity of miR-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin signaling. Thus, miR-490-3p may represent a potential therapeutic target for triple-negative breast cancer.

  8. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors.

  9. rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher squamous-cell carcinoma risk

  10. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC with aberrant WNT/beta-catenin signaling pathway.

  11. TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks.

  12. The variability of genes encoding for TERF1 and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.

  13. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp and Tyr) in the hydrophobic region at the induced pocket of TNKS1/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS proteins.

  14. Data indicate a basis for development of flavones as tankyrase inhibitors and suggest the development of other structurally related inhibitors.

  15. Data suggest that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.

  16. Study reports crystal structures of a representative ankyrin repeat clusters of TNKS2 bound to targeting peptides from six substrates.

  17. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins

  18. TNKS2 bound to Epstein-Barr virus origin of plasmid replication in coimmunoprecipitation experiments with transfected cell lysates.

  19. pathologic overexpression of tankyrase 2 in some tumors may be a result of the cancer-related adaptation of the malignant cells dependent on tankyrase activity.

  20. TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation.

  2. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

  3. a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported.

  4. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  5. TNKS2 is required in insulin-stimulated glucose disposal.

  6. Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.

  7. Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands.

  8. inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.

  9. Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.

  10. tankyrase 2is essential but redundant for mouse embryonic development

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Antigen Profile

Protein Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.

Gene names and symbols associated with TNKS2

  • tankyrase 2 (TNKS2) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (Tnks2) antibody
  • tankyrase 2 (Tnks2) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2) antibody
  • tankyrase 2 (tnks2) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog (tnks.S) antibody
  • 5430432P15Rik antibody
  • AA517131 antibody
  • AI662480 antibody
  • ARTD6 antibody
  • PARP-5b antibody
  • PARP-5c antibody
  • PARP5B antibody
  • PARP5C antibody
  • pART6 antibody
  • Tank2 antibody
  • tankyrase-1 antibody
  • tankyrase-2 antibody
  • TNKL antibody
  • tnks antibody
  • TNKS-2 antibody
  • tnks.L antibody
  • tnks2 antibody

Protein level used designations for TNKS2

ADP-ribosyltransferase diphtheria toxin-like 6 , TNKS-2 , TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , poly [ADP-ribose] polymerase 5B , tankyrase 2 , tankyrase II , tankyrase-2 , tankyrase-like protein , tankyrase-related protein , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , tankyrase-2-like , LOW QUALITY PROTEIN: tankyrase-2 , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase L homeolog , tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog

GENE ID SPECIES
80351 Homo sapiens
74493 Mus musculus
309512 Rattus norvegicus
374253 Gallus gallus
533901 Bos taurus
698050 Macaca mulatta
100061968 Equus caballus
100391147 Callithrix jacchus
100539557 Meleagris gallopavo
100567928 Anolis carolinensis
100591011 Nomascus leucogenys
100154520 Sus scrofa
100855568 Canis lupus familiaris
100719373 Cavia porcellus
495279 Xenopus laevis
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