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Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010].. Additionally we are shipping and many more products for this protein.
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Mouse (Murine) Polyclonal TET3 Primary Antibody for WB - ABIN2668513
Otani, Kimura, Sharif, Endo, Mishima, Kawakami, Koseki, Shirakawa, Suetake, Tajima: Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells. in PLoS ONE 2013
Show all 2 Pubmed References
Mouse (Murine) Monoclonal TET3 Primary Antibody for ICC, IF - ABIN5563988
Bauer, Göbel, Nagaraj, Colantuoni, Wang, Müller, Kremmer, Rottach, Leonhardt: Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT). in The Journal of biological chemistry 2015
Human Polyclonal TET3 Primary Antibody for IHC, IHC (p) - ABIN4358587
Ni, Dansranjavin, Rogenhofer, Oeztuerk, Deuker, Bergmann, Schuppe, Wagenlehner, Weidner, Steger, Schagdarsurengin: TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility. in Human reproduction (Oxford, England) 2016
DNMT3A (show DNMT3A Antibodies) senses the TGF-beta (show TGFB1 Antibodies) signal and silences TET2 (show TET2 Antibodies) and TET3 promoters to induce the epithelial-mesenchymal transition-like process and metastasis in melanoma.
Patients with mutations 6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1 (show ASXL1 Antibodies), TET2 (show TET2 Antibodies), TET3, KDM1A (show KDM1A Antibodies) and MSH6 (show MSH6 Antibodies) were found in 25% of patients. TET2 (show TET2 Antibodies) or TET3, AKT1 (show AKT1 Antibodies) and RUNX1 (show RUNX1 Antibodies) were mutated in one patient each. ASXL1 (show ASXL1 Antibodies) was mutated within exon 12 in three cases
Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as modulators of TET levels and activity. RA or retinol enhances 5hmC production in naive embryonic stem cells by activation of TET2 (show TET2 Antibodies) and TET3 transcription, whereas ascorbate potentiates TET activity and 5hmC production through enhanced Fe(2+) recycling, and not as a cofactor as reported previously
TET3-5-hydroxymethylcytosine was upregulated in the femoral head tissues of SAON patients and MLO-Y4 cells with dexamethasone (Dex) treatment.
Overexpression of the wild-type TET1 (show TET1 Antibodies)/2/3 3'UTR (show UTS2R Antibodies) caused a significant increase in EZH2 (show EZH2 Antibodies) expression and tumor growth, whereas the mutation in miR (show MLXIP Antibodies)-26-binding sites abolished this effect.
Because the DNA hypomethylation might be a result of TET dioxygenase activity, the study examined expression of TET1 (show TET1 Antibodies)-3 enzymes and the level of their product, 5-hydroxymethylcytosine (5hmC), in a panel of histologically characterized seminomas and non-seminomatous germ cell tumors. The study found highly increased expression of TET1 (show TET1 Antibodies) dioxygenase in most seminomas and strong TET1 (show TET1 Antibodies) staining in seminoma cells.
findings have identified distinct roles for TET2 (show TET2 Antibodies) and TET3 in human erythropoiesis, and provide new insights into their role in regulating human erythroid differentiation at distinct stages of development.
We found that TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) messenger RNA expression was lower and TET3 was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 (show TET1 Antibodies) and TET2 (show TET2 Antibodies) was found, but no correlation was observed in the case of TET3.
TET1 (show TET1 Antibodies), TET2 (show TET2 Antibodies), and TET3 genes are downregulated in endometriosis.
Results revealed that TET3 acted as a suppressor of ovarian cancer by demethylating miR (show MLXIP Antibodies)-30d precursor gene promoter to block TGF-beta1 (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition.
results provide novel insight into ATR (show ATR Antibodies)-mediated DNA damage response, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability.
TET3 negatively regulates type I IFN production.
Tet3, a DNA dioxygenase, can rapidly and efficiently convert fibroblasts directly into functional neurons.
Here the authors show that concomitant loss of Tet2 (show TET2 Antibodies) and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 (show IRF4 Antibodies) expression and impaired the germline transcription and rearrangement of the Igkappa locus.
this study shows that simultaneous deletion of Tet2 (show TET2 Antibodies) and Tet3 in mouse CD4 (show CD4 Antibodies)+CD8 (show CD8A Antibodies)+ double-positive thymocytes results in dysregulated development and proliferation of invariant natural killer T cells
The CXXC domain of Tet3 has the capacity to bind to unmethylated and carboxylated cytosines at CpG sequences and a very restricted genomic localization pattern with a preference for transcription start sites.
Genetic ablation of TET3 in oocytes had no significant effect on oocyte development.
the stability of Foxp3 (show FOXP3 Antibodies) expression is markedly compromised in T reg (show KCNH2 Antibodies) cells from Tet2 (show TET2 Antibodies)/Tet3 double-deficient mice.
The DNA demethylation marks are dynamically regulated in both in vivo and in vitro aging conditions, which are associated with Tet3 over-expression and Tdg (show TDG Antibodies) repression.
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009
probable methylcytosine dioxygenase TET3
, tet oncogene family member 3
, methylcytosine dioxygenase TET3