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TBXA2R encodes a member of the G protein-coupled receptor family.
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Thromboxane A2 receptor is expressed in both vagal and spinal neurons. Thromboxane A(2) may elicit stronger vagal or parasympathetic reflexes in the rabbit when released during tissue trauma depending on the location of release.
Data suggest that in hypoxic pulmonary hypertension, loss of site-specific phosphorylation of TBXA2R results in agonist hyper-responsiveness; Ser324 appears to be primary residue phosphorylated during protein kinase A activation of TBXA2R.
Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae.
We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt (show AKT1 Antibodies)-eNOS (show NOS3 Antibodies) pathway.
data presented herein propose a novel diagnostic and prognostic potential for TPalpha (show HADHA Antibodies) and TPbeta in the histopathological assessment of PCa (show FLVCR1 Antibodies). While TPalpha (show HADHA Antibodies) and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha (show HADHA Antibodies) or both correlated with increased risk of recurrence and reduced disease-free survival time.
TBXA2R is a novel breast cancer-associated (show ARID4B Antibodies) gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC).
TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients.
We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 (show CCT7 Antibodies) interaction and plays an important role in TPbeta maturation and cell-surface expression.
TBXA2R +924C/T polymorphism is associated with asthma risk
A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 (show TBC1D9 Antibodies) C3435T, TBXA2R (rs1131882), and PLA2G7 (show Lp-PLA2 Antibodies) (rs1051931-rs7756935) polymorphisms.
Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase (show MAPK1 Antibodies) pathway, up-regulation of cyclin B1 (show CCNB1 Antibodies)/CDK1 (show CDK1 Antibodies) expression, and down-regulation of apoptosis.
The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia.
platelet GP6 (show GP6 Antibodies) and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation
Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation.
PKCalpha (show PKCa Antibodies) deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism.
Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein (show CRP Antibodies).
The thromboxane A(2) receptor agonist 11-deoxy PGF (show PTGFR Antibodies)(2alpha) can partially alleviate embryo crowding in the Lpar3 (show LPAR3 Antibodies)((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3 (show LPAR3 Antibodies)((-/-)) females.
We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow.
thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury
Thromboxane A2 receptor activation via PKC-zeta (show PRKCZ Antibodies)-mediated NAD(P)H (show NQO1 Antibodies) oxidase activation increases superoxide and peroxynitrite, resulting in eNOS (show NOS3 Antibodies) uncoupling in endothelial cells.
thromboxane synthase, prostacyclin synthase (show PTGIS Antibodies) and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene.
thromboxane A2 receptor
, prostanoid TP receptor
, TXA2 receptor
, thromboxane prostanoid
, Thromboxane receptor