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regulates thyroid gland function\; mediates phospholipase C activation and increased intracellular calcium [RGD, Feb 2006].. Additionally we are shipping TRHR Kits (5) and and many more products for this protein.
Showing 10 out of 80 products:
Human Polyclonal TRHR Primary Antibody for IF, ELISA - ABIN1536075
Liu, Ha, Cui, Wang, Yan, Fu, Quan, Zhou, Yang: JNK pathway decreases thyroid hormones via TRH receptor: A novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. in Toxicology 2012
Show all 3 Pubmed References
Dog (Canine) Polyclonal TRHR Primary Antibody for IHC (p) - ABIN270556
Xiao, Segal: Biological sequence classification utilizing positive and unlabeled data. in Bioinformatics (Oxford, England) 2008
Human Polyclonal TRHR Primary Antibody for IHC (p) - ABIN2476943
García, Porto, Dieuzeide, Landa, Kirszner, Plotquin, Gonzalez, Pirola: Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. in Hypertension 2001
activating TRH/TRH (show TRH Antibodies)-R1 signaling seems not to be sufficient for gastric stimulation of acylated ghrelin (show GHRL Antibodies) production
The central nervous systems effects of taltirelin are mediated primarily by TRH-R1 and not TRH (show TRH Antibodies)-R2.
We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH (show TRH Antibodies)-R2 forms and maintains these complexes more efficiently than TRH-R1.
three distinct and discontinuous regions of the TSHR (aa 246-260 and 277-296 on the TSHR A subunit) and aa 381-385 (on the TSHR B subunit) fold together to form a complex TSH binding pocket.
the TSHR (show TSHR Antibodies) may not be similar to other model proteins used to define the concept of central immune tolerance.
TRH-R1 has a role in mouse lactation and mice lacking the receptor show signs of central hypothyroidism
Thyrotropin-releasing hormone (show TRH Antibodies) binding induces separation of cytoplasmic ends of TRH receptor type 1 transmembrane helix 5 (TMH5) and TMH6 and a rotation of TMH6 that could promote interactions between G proteins and key residues within the TRH receptor.
Beta-arrestin has a role in desensitization and internalization but not phosphorylation of the thyrotropin-releasing hormone receptor, which causes translocation of endogenous GRK2 (show ADRBK1 Antibodies) to the plasma membrane
the endogenous TRH (show TRH Antibodies) system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways
A flexible molecular docking procedure revealed that TRH (show TRH Antibodies) establishes a direct interaction with W6.48 in TRH (show TRH Antibodies)-R2 but not in TRH-R1.
a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH (show TRH Antibodies) binding and TRHR-Gq coupling and signaling
rs16892496 polymorphism in the TRHR gene may play a role in FFM (show ABCA4 Antibodies) variation.
The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior.
Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails.
A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation.
TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH (show TRH Antibodies) administration in GH cell adenomas.
Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking.
TRHR gene is an important gene for LBM variation.
analysis of the effect of subcellular trafficking of the TRH receptor
Distribution of the mRNAs encoding proTRH and the three TRH (show TRH Antibodies) receptors in the central nervous system and pituitary of X. laevis is described.
TRHR (pTRHR) gene was localized to chromosome 4; full-length cDNA of pTRHR was cloned and sequenced; pTRHR contains an open reading frame encoding 398 amino acids and shares 96.2% amino acid identity to human TRHR.
regulates thyroid gland function\; mediates phospholipase C activation and increased intracellular calcium
thyrotropin-releasing hormone receptor
, thyroliberin receptor
, thyrotropin releasing hormone receptor