TRHR antibody (AA 195-244)

Catalog No. ABIN1536075

This Rabbit Polyclonal antibody specifically detects TRHR in WB, ELISA and IF. It exhibits reactivity toward Human, Rat, Mouse and Monkey. It has been mentioned in 2+ publications

Quick Overview for TRHR antibody (AA 195-244) (ABIN1536075)

Target: TRHR (Thyrotropin-Releasing Hormone Receptor (TRHR))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRHR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-TRHR Antibody

Binding Specificity: AA 195-244

Purpose: TRH-R1 Antibody

Specificity: TRH-R1 Polyclonal Antibody detects endogenous levels of TRH-R1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TRHR. AA range:195-244

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

References for anti-TRHR antibody (ABIN1536075)

Liu, Li, Ha, Qi, Duan, Yang: "The PI3K/Akt and ERK pathways elevate thyroid hormone receptor ?1 and TRH receptor to decrease thyroid hormones after exposure to PCB153 and p,p'-DDE." in: Chemosphere, Vol. 118, pp. 229-38, (2014) (PubMed).

Liu, Ha, Cui, Wang, Yan, Fu, Quan, Zhou, Yang: "JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153." in: Toxicology, Vol. 302, Issue 1, pp. 68-76, (2012) (PubMed).

Target Details for TRHR

Target: TRHR (Thyrotropin-Releasing Hormone Receptor (TRHR))

Alternative Name: TRHR

Background:

Synonyms: TRHR, Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor

Background: This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011],

Gene Name: TRHR

Protein Name: Thyrotropin-releasing hormone receptor

Molecular Weight: 45 kDa

Gene ID: 7201

OMIM: 188545

UniProt: P34981