Transgelin 2 Proteins (TAGLN2)

Mouse (Murine) Transgelin 2 (TAGLN2) interaction partners

1. transgelin-2 may also be involved in IS stability in B-cells, thereby influencing T-cell function

2. All these results indicated a crucial role for Tagln2 in TECs for tumor development and metastasis.

3. A novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the immunological synapse.

4. The results indicate that miR (show MLXIP Proteins)-133b may play important roles in the growth and maturation of oocytes by regulating its potential target, TAGLN2, at both transcription and translation levels.

5. we demonstrate that methylation of SM22alpha (show TAGLN Proteins) promoter is an important event in vascular smooth muscle cell calcification and that high phosphate induces this epigenetic modification.

6. data demonstrate that SM22beta is a novel actin-associated protein with a unique cell lineage-restricted pattern of expression

Human Transgelin 2 (TAGLN2) interaction partners

1. Results show that Increased expression of TAGLN2 is associated with increasing tumor grade in glioma and poor patient survival. Knockdown experiments highlighted the function of TAGLN2 in promoting glioma cell invasion, the EMT (show ITK Proteins) phenotype, and tumor growth.

2. Our data support a novel mechanism in diabetes-associated PDAC by which transgelin-2 mediates proliferation of PDAC cells upon insulin (show INS Proteins) stimulation.

3. Results suggest that TAGLN2 might regulate activation and migration of B-cells, in particular, the entry of activated B-cells into the follicle.

4. we reviewed the basic characteristics and function of Transgelin-2 and its biological role in various types of diseases in order to provide the theoretical basis for further research and new perspectives on cancer development.

5. Our data demonstrated that TAGLN2 might be an HBx induced positive host factor involved in HBV transcription and replication and HBx related liver fibrosis and tumorigenesis

6. Transgelin-2 plays functional roles in the progression of cervical squamous cell carcinoma. Suppression of Transgelin-2 may be a new strategy for the treatment of cervical squamous cell carcinoma.

7. It is a target gene of miR-1.

8. Salvianolic acid A can reverse the paclitaxel resistance and inhibit the migration and invasion abilities of human breast cancer cells by down-regulating the expression of transgelin 2.

9. Proteomics result showed TAGLN2 as the most significant overexpression in individual bladder cancer tissues and urine specimens, and thus represents a potential biomarker for noninvasive screening for bladder cancer.

10. TAGLN2 modulates hypoxia-induced apoptosis via caspase-8 (show CASP8 Proteins) apoptotic pathway. Taken together, our data demonstrated the roles of miR (show MLXIP Proteins)-133a in hypoxia-induced apoptotic and implicate its potential in cardiac dysfunctions therapy.