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TKT encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Additionally we are shipping Transketolase Antibodies (62) and Transketolase Kits (18) and many more products for this protein.
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Over-expressed and hypo-methylated TKT gene is associated with hepatocellular carcinoma.
The observed associations of genetic variation in transketolase enzyme with neuropathic symptoms and reduced thermal sensation in recent-onset diabetes suggest a role of pathways metabolizing glycolytic intermediates in early diabetic neuropathy.
reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients
Mutations in TKT gene is associated with a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects.
transketolase (TKT)is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress.
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Akt1 phosphorylates TKT on Thr382, markedly enhancing enzyme activity.
TKT rs3736156 identified significant differences in the onset of cardiovascular event in patients having genotypes AG + AA versus GG
basal TK activity was decreased in cases with diabetic neuropathy
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1).
No transketolase activity of TKTDelta38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism
TKT is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4.
This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Zinc finger protein 746 overexpression suppresses TKT transcription via IRS-like motif in the TKT promoter.
decreased TK activity leads to pentose-phosphate pathway dysfunction and contributes to impaired hippocampal neurogenesis induced by thiamine deficiency
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, hypothetical protein
, transketolase-like protein 2
, transketolase (Wernicke-Korsakoff syndrome)
, transketolase-like 2