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TKT encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Additionally we are shipping Transketolase Antibodies (44) and Transketolase Kits (15) and many more products for this protein.
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The observed associations of genetic variation in transketolase enzyme with neuropathic symptoms and reduced thermal sensation in recent-onset diabetes suggest a role of pathways metabolizing glycolytic intermediates in early diabetic neuropathy.
reduced expression of transketolase in pyrimidine 5'-nucleotidase (show NT5E Proteins) deficient patients
Mutations in TKT (show DDR2 Proteins) gene is associated with a Syndrome Including Short Stature, Developmental Delay, and Congenital Heart Defects.
transketolase (TKT)is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress.
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Akt1 (show AKT1 Proteins) phosphorylates TKT (show DDR2 Proteins) on Thr382, markedly enhancing enzyme activity.
TKT (show DDR2 Proteins) rs3736156 identified significant differences in the onset of cardiovascular event in patients having genotypes AG + AA versus GG
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1).
No transketolase activity of TKTDelta38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism
Zinc finger protein 746 overexpression suppresses TKT transcription via IRS (show IARS Proteins)-like motif in the TKT promoter.
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, hypothetical protein
, transketolase-like protein 2
, transketolase (Wernicke-Korsakoff syndrome)
, transketolase-like 2