Tribbles Homolog 2 (Drosophila) Proteins (TRIB2)

TRIB2 encodes one of three members of the Tribbles family. Additionally we are shipping Tribbles Homolog 2 (Drosophila) Antibodies (78) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIB2 28951 Q92519
TRIB2 217410 Q8K4K3
Rat TRIB2 TRIB2 313974  
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Top Tribbles Homolog 2 (Drosophila) Proteins at

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Baculovirus infected Insect Cells Human GST tag,His tag 50 μg Log in to see 14 to 16 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days

TRIB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Tribbles Homolog 2 (Drosophila) (TRIB2) Interaction Partners

Xenopus laevis Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development

Human Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. Data indicate a regulatory mechanism underlying drug resistance and suggest that tribbles homologue 2 (TRIB2) functions as a regulatory component of the PI3K network, activating AKT in cancer cells.

  2. Due to the downregulation of MDR1 and MRP1, the intracellular accumulation of ADM was increased in the transfected cells compared with that in the parental K562/ADM cells..Our research revealed that protein expression of the ERK signaling pathway was inhibited by downregulating TRIB2, indicating that the ERK pathway was involved in cell drug resistance and proliferation.

  3. Trib2 is important for maintaining self-renewal in ES cells and for pluripotency induction during the reprogramming process.

  4. O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer.

  5. Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance.

  6. our data show that excess p30 cooperated with TRIB2 only in the presence of p42 to accelerate acute myeloid leukaemia (AML), and the direct interaction and degradation of C/EBPa p42 is required for TRIB2-mediated AML.

  7. miR-206 and miR-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3.

  8. Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2, CIDEA, PPARGC1A, and PRDM16 showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype.

  9. Data show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain.

  10. High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia.

  11. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.

  12. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 were involved in the pathogenesis of inflammation.

  13. Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.

  14. Studies indicate that the molecular interactions that take place between tribbles homolog 2 (Drosophila) protein (TRIB2) and factors involved in the ubiquitin proteasome system (UPS) are varied and have differential downstream effects.

  15. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs.

  16. Studies show that TRIB1 and TRIB2 are highly expressed in molecularly-defined sub-types of acute myeloid leukemia (AML).

  17. Studies show a remarkable reduction in tribbles 2 protein (Trib2) expression during oocyte maturation whereas tribbles 1 protein (Trib1) and tribbles 3 protein (Trib3) expression was significantly increased during this process.

  18. The results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy.

  19. Data suggest that TRB2 exhibits metal-independent autophosphorylation activity, low affinity ATP binding/hydrolysis, and a conserved catalytic lysine residue in the active site (rather than the asparagine in many metal-dependent kinases).

  20. TRIB2 negatively regulates Wnt activity through a reduction in protein stability of TCF4 and beta-Catenin

Mouse (Murine) Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. results suggest that Trib2 positively promotes early erythrocyte differentiation and is essential for tolerance to hemolysis.

  2. The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction.

  3. These data indicate that Trib2 has a complex role in the pathogenesis of Notch-driven T-ALL, which may vary between different T-ALL subtypes.

  4. TRIB1 and TRIB3 are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.

  5. we identify the contribution of dysregulated C/EBPalpha and E2F1 to elevated Trib2 expression and leukemic cell survival

  6. Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia.

  7. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.

  8. Data identify Tribbles homolog 2 as an oncogene that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha.

  9. describe suppression of adipocyte differentiation by TRBs Trib1, Trib2, Trib3

  10. Mice reconstituted with HSC cotransduced with HoxA9 and Trib2 had accelerated onset of AML compared to either gene alone

  11. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.

  12. These results suggest that Trb2 plays minimal roles during kidney and mouse development.

Tribbles Homolog 2 (Drosophila) (TRIB2) Protein Profile

Protein Summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with TRIB2

  • tribbles pseudokinase 2 (TRIB2)
  • tribbles pseudokinase 2 (trib2)
  • tribbles pseudokinase 2 S homeolog (trib2.S)
  • tribbles pseudokinase 2 (Trib2)
  • AW319517 protein
  • C5FW protein
  • GS3955 protein
  • RGD1564451 protein
  • TRB-2 protein
  • TRB2 protein
  • TRIB2 protein
  • xtrb2 protein
  • Xtrbl protein

Protein level used designations for TRIB2

tribbles homolog 2 (Drosophila) , tribbles homolog 2-like , tribbles homolog 2 , serine/threonine protein kinase , tribbles-like protein 2 , TRB-2

459038 Pan troglodytes
100331041 Danio rerio
394677 Xenopus (Silurana) tropicalis
100357208 Oryctolagus cuniculus
100528799 Ictalurus punctatus
378920 Xenopus laevis
378919 Gallus gallus
28951 Homo sapiens
403884 Canis lupus familiaris
352960 Bos taurus
217410 Mus musculus
313974 Rattus norvegicus
100173599 Pongo abelii
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