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Promotes the exchange of GDP by GTP. Additionally we are shipping TRIO Kits (4) and TRIO Proteins (2) and many more products for this protein.
Showing 10 out of 12 products:
Human Polyclonal TRIO Primary Antibody for ELISA, WB - ABIN563257
Yano, Yamazaki, Adachi, Okawa, Fort, Uji, Tsukita, Tsukita: Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. in The Journal of cell biology 2011
Show all 3 Pubmed References
Results revealed that TRIO high expression levels in cervical cancer were correlated with lymph node metastasis. Its inhibition significantly decreased the migration and invasion abilities of cervical cancer cells through the RhoA (show RHOA Antibodies)/ROCK signaling pathway.
Trio plays a role in activating Rac1 in podocytes both in basal conditions and when stimulated with TGFbeta1 (show TGFB1 Antibodies). We speculate that Trio may have dual roles; it may play important roles in podocyte development but it may also regulate pathological Rac1 hyperactivation in the context of TGFbeta1 (show TGFB1 Antibodies)-mediated podocyte injury and glomerulosclerosis.
Genetic damage to both TGEF domains altered TRIO catalytic activity, decreasing TGEF1 activity and increasing TGEF2 activity.
A recurrent rearrangement involving TRIO with various partners was identified in 5.1% of non-translocation-related sarcoma cases. TRIO translocations are either intrachromosomal with TERT (show TERT Antibodies) or interchromosomal with LINC01504 or ZNF558 (show ZNF558 Antibodies). All translocations led to a truncated TRIO protein either directly or indirectly by alternative splicing. TRIO rearrangement is associated with a modified transcriptomic program.
Study identifies a large cluster of de novo mutations in the GEF1 (show ARHGEF1 Antibodies) domain of Trio in whole-exome sequencing data from individuals with autism spectrum disorder.
The findings provide a mechanism for the presynaptic targeting of Trio and support a model in which Piccolo (show PCLO Antibodies) and Bassoon (show BSN Antibodies) play a role in regulating neurotransmission through interactions with proteins, including Trio, that modulate the dynamic assembly of F-actin during cycles of synaptic vesicle exo (show PHM Antibodies)- and endocytosis.
TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function.
our data show the importance of spatio-temporal regulation of the actin cytoskeleton through Trio and Rac1 at VE-cadherin (show CDH5 Antibodies)-based cell-cell junctions in the maintenance of the endothelial barrier.
Aberrant expression of TRIO might play an important role in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) through promoting cell proliferation and invasion, and TRIO may be a novel therapeutic target for the treatment of HCC (show FAM126A Antibodies)
Strong statistical evidence for a causal role of TRIO in neurodevelopmental and neuropsychiatric disorders.
The Trio gene regulates the neuronal development of the hippocampus and that it affects the intelligence of adult mice.
Trio may serve as a a signal integrator decoding extrinsic signals to Rho GTPases for cytoskeleton organization
M-cadherin-dependent adhesion can activate Rac1 via the Rho-GEF (show ARHGEF2 Antibodies) Trio at the time of myoblast fusion.
the results show a link between Trio activity,Rac1 activation,neuronal organization,and recruitment of Cadherin-11 receptor to form a complex with Trio in hindbrain embryology.
findings establish Trio as a guanine nucleotide exchange factor that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1
Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.
, triple functional domain (PTPRF interacting)
, triple functional domain protein