Tumor Necrosis Factor (Ligand) Superfamily, Member 8 Proteins (TNFSF8)

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) interaction partners

1. Data indicate that CD30L/CD30 (show TNFRSF8 Proteins) axis plays a modulatory role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE).

2. Altered expression of CD30L and IL-3 (show IL-3 Proteins) may be potential biomarkers for hepatotoxicity induced by D. bulbifera.

3. role in the maintenance and activation of IL-17A (show IL17A Proteins)-producing gammadelta T cells

4. Interference of the CD30 (show TNFRSF8 Proteins)-CD30L pathway reduces atherosclerosis development.

5. It is shown here that CD30L knock out (KO) mice are highly susceptible to primary infection with Listeria monocytogenes as assessed by the survival rate.

6. role of CD30L/CD30 (show TNFRSF8 Proteins) interactions in allergic rhinitis; results suggest that CD30L plays an important role in allergic rhinitis

7. Modulation of CD30L/CD30 (show TNFRSF8 Proteins) signaling by soluble CD30 (show TNFRSF8 Proteins) could be a novel biological therapy for inflammatory diseases associated with Th17 responses.

8. Studies demonstrate that CD30L/CD30 (show TNFRSF8 Proteins) signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation.

9. Characterization of the murine CD30 ligand (CD153) gene: gene structure and expression.

10. CD30L is required for generation of long-lived memory CD8 (show CD8A Proteins)+ T cells; CD30L signaling triggers homing receptors for T(central memory) cells.

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) interaction partners

1. Data suggest that Brentuximab Vedotin (SGN-35) damaged CD30 ligand (CD30L)-immune cells through CD30 (show TNFRSF8 Proteins) extracellular vesicles (EVs).

2. circulant sCD30L is functionally active and that it may favor persistence of active inflammation by inducing apoptosis of CD30 (show TNFRSF8 Proteins)(+)T cells, known to down-modulate inflammation in rheumatoid synovitis.

3. TNFSF8 is an important leprosy T1R susceptibility gene.

4. The heritability of IgA levels is moderate and can partly be attributable to common variation in the CD30L locus.

5. soluble apoptosis markers as sFas-L, Caspase-9 (show CASP9 Proteins), Caspase-8 (show CASP8 Proteins) and sCD153 were significantly higher in stage III obesity patients compared obese patients without food allergy

6. a novel and unexpected role for CD30 (show TNFRSF8 Proteins)/CD30L that contributes to proinflammatory immune responses

7. The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated.

8. Positional candidate gene screening in the SPA2 locus allowed us to identify and replicate an association between a rare SNP located in TNFSF8 and spondylarthritis.

9. a possible role of novel TNFSF8 variants in susceptibility to lung cancer.

10. capability to up-regulate expression of CD30 (show TNFRSF8 Proteins), release of soluble CD30 (show TNFRSF8 Proteins) and production of IL-4 (show IL4 Proteins) in pre-activated T cells upon co-culture