Quick Overview for TNFSF8 Protein (ABIN7317038)
Target
See all TNFSF8 ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human CD153/CD30L/TNFSF8 Protein
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Sequence
- Gln 63-Asp 234
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Characteristics
- A DNA sequence encoding the human CD30L (NP_001235.1) (Gln63-Asp234) was expressed with two additional amino acids (Gly & Pro ) at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 63-234) (Active) protein (mFc Tag)
TNFSF8 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 63-234) protein (His-DYKDDDDK-Strep II Tag)TNFSF8 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 99-330) protein (His tag,mFc Tag)TNFSF8 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ADA, AM, IA, ScA
Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 1-234) protein (GST tag)TNFSF8 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 63-234) (Active) protein (His tag)TNFSF8 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 85 % SDS, AcA Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8) (AA 63-234) (Active) protein (Fc Tag)TNFSF8 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- TNFSF8 (Tumor Necrosis Factor (Ligand) Superfamily, Member 8 (TNFSF8))
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Alternative Name
- CD153/CD30L/TNFSF8
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Background
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Background: CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.
Synonym: CD153,CD30L,CD30LG
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Molecular Weight
- 19.6 kDa
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NCBI Accession
- NP_001235
Target
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