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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (91) and Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteins (36) and many more products for this protein.
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Human Monoclonal TNFRSF11B Primary Antibody for CyTOF, FACS - ABIN252469
Kobayashi, Hashimoto, Miyamoto, Kanaoka, Miyazaki-Kawashita, Nakashima, Shibata, Kobayashi, Kato, Sakai: Force-induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor beta and osteoprotegerin expression. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001
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Cow (Bovine) Polyclonal TNFRSF11B Primary Antibody for IHC, ELISA - ABIN1582232
Fradet, Sorel, Bouazza, Goehrig, Dépalle, Bellahcène, Castronovo, Follet, Descotes, Aubin, Clézardin, Bonnelye: Dual function of ERR? in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin. in Cancer research 2011
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Human Monoclonal TNFRSF11B Primary Antibody for ICC, FACS - ABIN969439
Golledge, Biros, Clancy, Cooper, Palmer, Norman: A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men. in American journal of hypertension 2009
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Human Monoclonal TNFRSF11B Primary Antibody for IHC, ELISA - ABIN969440
Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ... in American journal of human genetics 2009
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Human Monoclonal TNFRSF11B Primary Antibody for WB - ABIN2668734
Sood, Balasubramanian, Higham, Fernando, Harrison: Osteoprotegerin (OPG) and related proteins (RANK, RANKL and TRAIL) in thyroid disease. in World journal of surgery 2011
Human Monoclonal TNFRSF11B Primary Antibody for ELISA, WB - ABIN2475981
Westheimer: Why nature chose phosphates. in Science (New York, N.Y.) 1987
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OPG has a role in cancer progression, especially breast cancer [review]
OPG rs2073618 polymorphism could be a possible genetic marker for the prediction of increased risk for carotid plaque burden as a measure of advanced subclinical atherosclerosis in T2DM subjects.
The compound with greatest potential is E05657 with high activity and low effective concentration in the HTS (show APCDD1 Antibodies) system. It increases the OPG/RANKL (show TNFSF11 Antibodies) ratio and OPG secretion, decreases the NFATc1 (show NFATC1 Antibodies) expression, and reduces osteoclastogenesis in vitro
OPG T950C polymorphism might be associated with an increased osteoporosis risk in the Chinese population
We have concluded that low OPG levels may be associated with osteoporosis in ulcerative colitis, but it is not correlated with the c.-223C > T polymorphism in the TNFRSF11B gene.
RANKL (show TNFSF11 Antibodies)/Osteoprotegerin have roles in bone turnover in Hashimoto Thyroiditis
High OPG expression is associated with colorectal carcinoma.
Data suggest that elevated plasma levels of osteoprotegerin/TNFRSF11B correlate with increased risk of cardiovascular comorbidities in children and adolescents with type 1 diabetes (as compared to healthy control subjects); thus, osteoprotegerin/TNFRSF11B may serve as biomarker of cardiovascular risk in these patients. This study was conducted in Tunisia.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (show TNFSF11 Antibodies)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (show TNFSF11 Antibodies) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (show TNFSF11 Antibodies) ratio towards an unbalanced or a balanced status. [review]
Formulation and in vitro and in vivo evaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration
findings demonstrate that mTORC1 activation-stimulated RANKL (show TNFSF11 Antibodies) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (show TNFSF11 Antibodies) axis via negative regulation of beta-catenin (show CTNNB1 Antibodies).
RANK/RANKL (show TNFSF11 Antibodies) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (show TNFSF11 Antibodies) rather than elevated RANKL (show TNFSF11 Antibodies) expression
Diabetes significantly increased OPG (show TNFSF11 Antibodies) and the OPG (show TNFSF11 Antibodies)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (show TNFSF11 Antibodies) and reduced TRAIL expression, thus increasing cardiac OPG (show TNFSF11 Antibodies)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (show TNFSF11 Antibodies) interaction and osteoclastogenesis.
OPG (show TNFSF11 Antibodies) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (show TNFSF11 Antibodies) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (show MAPK14 Antibodies) mitogen-activated protein kinase (show MAPK1 Antibodies) (MAPK (show MAPK1 Antibodies)) in paired related homeobox 1 (show PRRX1 Antibodies) protein (Prx1 (show PRDX1 Antibodies)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (show TNFSF11 Antibodies) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 (show RUNX2 Antibodies) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Antibodies) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like