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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b Antibodies (192) and Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (104) and many more products for this protein.
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We conclude that non-small cell lung cancer patients have a higher content of OPG in bronchoalveolar lavage fluid than healthy people.
positive correlation of OPG with age and an inverse correlation with IGF-I (show IGF1 Proteins) favor the compensatory response of OPG against bone loss in the aging skeleton
The results indicated that mice treated with low levels of human recombinant OPG may have a more stable aneurysmal phenotype due to compensatory production of collagen and increased vessel wall thickness of the aorta, potentially protecting the aneurysm from rupture.
TNF-alpha (show TNF Proteins), DKK1 (show DKK1 Proteins), and OPG have roles in pathogenesis of knee osteoarthritis
OPG mRNA expression was higher in tumour tissue from patients with metastatic prostate cancer compared to local disease. The RANKL/OPG (show TNFSF11 Proteins) ratio was low in normal prostate tissue and high in tumours with bone metastases. Expression was high in BPH (show GLI3 Proteins) tissue but did not exceed as much as in the tumour tissue.
results of this study concluded that the RANK, RANK-L and OPG system participates in bone remodeling after RME
In cardiovascular risks, OPG serum level might increase as a preventive compensatory mechanism to neutralize the RANKL (show TNFSF11 Proteins) level increment. The determination of the OPG-RANKL (show TNFSF11 Proteins) system is a diagnostic indicator for the intensity of vascular calcification and atherosclerosis in SSc (show CYP11A1 Proteins) patients.
Demonstrate that rs3134069 in TNFRSF11B increases risk of ischemic stroke by decreasing TNFRSF11B expression.
sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance
The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN (show SPP1 Proteins), OPG, and BMP2 (show BMP2 Proteins) genes in pathogenesis of aortic valve calcification.
Epithelial rests of Malassez may be associated with root resorption via OPG (show TNFSF11 Proteins), thus helping to explain the mechanism underlying root resorption.
findings demonstrate that mTORC1 activation-stimulated RANKL (show TNFSF11 Proteins) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (show TNFSF11 Proteins) axis via negative regulation of beta-catenin (show CTNNB1 Proteins).
RANK/RANKL (show TNFSF11 Proteins) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (show TNFSF11 Proteins) rather than elevated RANKL (show TNFSF11 Proteins) expression
Diabetes significantly increased OPG (show TNFSF11 Proteins) and the OPG (show TNFSF11 Proteins)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (show TNFSF11 Proteins) and reduced TRAIL expression, thus increasing cardiac OPG (show TNFSF11 Proteins)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (show TNFSF11 Proteins) interaction and osteoclastogenesis.
OPG (show TNFSF11 Proteins) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (show TNFSF11 Proteins) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (show MAPK14 Proteins) mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) in paired related homeobox 1 (show PRRX1 Proteins) protein (Prx1 (show PRDX1 Proteins)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (show TNFSF11 Proteins) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 (show RUNX2 Proteins) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Proteins) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like