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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Additionally we are shipping Tumor Necrosis Factor Receptor Superfamily, Member 11b Antibodies (197) and Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (98) and many more products for this protein.
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The study revealed an enhanced sensitivity of aortic valve interstitial cells to osteogenic inductors in aortic stenosis patients, which indicates probable implication of OPN (show SPP1 Proteins), OPG, and BMP2 (show BMP2 Proteins) genes in pathogenesis of aortic valve calcification.
Patients with metabolic syndrome have increased osteoprotegerin serum levels than healthy individuals; osteoprotegerin plays an important role in the development of arteriosclerosis, and the effect of osteoprotegerin on intima media thickness strongly depends on the extent of arteriosclerotic changes in metabolic syndrome
In African-Americans, higher OPG levels were associated with characteristics common in patients with heart failure with preserved ejection fraction (HFpEF) and were significantly associated with known precursors to HFpEF.
TRACP (show ACP5 Proteins)-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in coronary artery disease patients
Vascular smooth cells are a significant source of osteoprotegerin within the vasculature but that RANKL (show TNFSF11 Proteins), once present, downregulates this production and appears capable of preventing the "protective" upregulation of OPG seen with VSMCs exposed to physiological levels of cyclic strain.
higher serum OPG levels represent an independent risk factor for cardiovascular and fracture risk.
For the OPG gene, an association was observed between the group with chronic arthralgia and joint TMD (show TTN Proteins) and the control group (P=0.04). There was also a tendency towards an association of the haplotype CGCCAA with an increased risk of developing chronic joint pain, even in the absence of TMD (show TTN Proteins) (P=0.06).
Vitamin D, tumor necrosis factor (TNF)-alpha (show TNF Proteins), receptor activator of nuclear factor-KB ligand (RANKL (show TNFSF11 Proteins)), and OPG levels were determined in GCF (show GUCY2F Proteins) and serum. Baseline clinical parameters were similar in all periodontitis groups (P > 0.05) but were higher than that in controls
Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death.
down-regulated miR (show MLXIP Proteins)-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 (show RUNX2 Proteins) expression via the OPG/RANKL (show TNFSF11 Proteins) signaling pathway.
findings demonstrate that mTORC1 activation-stimulated RANKL (show TNFSF11 Proteins) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (show TNFSF11 Proteins) axis via negative regulation of beta-catenin (show CTNNB1 Proteins).
RANK/RANKL (show TNFSF11 Proteins) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (show TNFSF11 Proteins) rather than elevated RANKL (show TNFSF11 Proteins) expression
Diabetes significantly increased OPG (show TNFSF11 Proteins) and the OPG (show TNFSF11 Proteins)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (show TNFSF11 Proteins) and reduced TRAIL expression, thus increasing cardiac OPG (show TNFSF11 Proteins)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (show TNFSF11 Proteins) interaction and osteoclastogenesis.
OPG (show TNFSF11 Proteins) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (show TNFSF11 Proteins) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (show MAPK14 Proteins) mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) in paired related homeobox 1 (show PRRX1 Proteins) protein (Prx1 (show PRDX1 Proteins)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (show TNFSF11 Proteins) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 (show RUNX2 Proteins) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (show TNFSF11 Proteins) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like