anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) Antibodies

TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. Additionally we are shipping Tumor Protein P53 Binding Protein 2 Proteins (3) and Tumor Protein P53 Binding Protein 2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TP53BP2 7159 Q13625
TP53BP2 209456 Q8CG79
TP53BP2 305025  
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Top anti-Tumor Protein P53 Binding Protein 2 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TP53BP2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TP53BP2 Antibody (N-term) western blot analysis in T47D cell line lysates (35 µg/lane). This demonstrates the TP53BP2 antibody detected the TP53BP2 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Phospho-ASPP2 (Ser698) in lysates of Jurkat?, using Phospho-ASPP2 (Ser698) Antibody(ABIN6267847). 100 μL 11 to 12 Days
$450.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Anti-TP53BP2 / ASPP2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this ... 100 μL 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ASPP2 in lysates of Jurkat?, using ASPP2 Antibody(ABIN6268263). 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: NT2D1 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details
Dog Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$632.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti-ASPP2/p53BP2 Polyclonal Antibody, Unconjugated (ABIN674394) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: Mouse spleen lysate Lane 2: Mouse thymus lysate Lane 3: Mouse prostate lysate Lane 4: Mouse intestine lysate probed with Rabbit Anti-ASPP2/p53BP2 Polyclonal Antibody, Unconjugated (ABIN674394) at 1:300 overnight at 4 °C. Followed by conjugation to secondary antibody  at 1:5000 for 90 min at 37 °C. 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated WB Western blot analysis in T47D cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$639.83
Details

Top referenced anti-Tumor Protein P53 Binding Protein 2 Antibodies

  1. Human Polyclonal TP53BP2 Primary Antibody for IF (p), IHC (p) - ABIN674394 : Xie, Yang, Chi, Yang, Wang, Xu: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study. in Chinese journal of cancer 2017 (PubMed)

More Antibodies against Tumor Protein P53 Binding Protein 2 Interaction Partners

Human Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. p53 activation and XIAP suppression were two independent ways that ASPP2 enhance the sensitivity of chemotherapy.

  2. Our data demonstrates that ASPP2kappa plays a distinctive role as an antiapoptotic regulator of the TP53 checkpoint, rendering cells to a more aggressive phenotype as evidenced by proliferation and apoptosis rates - and ASPP2kappa expression results in acquisition of genomic mutations, a first initiating step in leukemogenesis.

  3. Study have provided evidence that ASPP2 has an inhibitory influence on triplenegative breast cancer (TNBC) growth and metastasis, and that this may rely on using the PI3K/AKT pathway in a p53independent manner.

  4. the abnormal expression of ASPP2 may play an important role for development and metastasis in esophageal squamous cell carcinoma.

  5. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  6. Results showed that protein expression levels of ASPP2 and P53 were significantly higher in esophageal squamous cell carcinoma tissues than in paired noncancerous tissues.

  7. Expression levels of TP53BP2, FBXO28, and FAM53A genes were associated with patient survival specifically in ER-positive, TP53-mutated tumors.

  8. These data together implicated a critical impact of MiR-205/ASPP2 on promoting epithelial-mesenchymal transition.

  9. ASPP2 is a key regulator of BECN1-dependent autophagy.

  10. ASPP2 suppresses invasion, peritoneal dissemination and TGF-beta1-induced EMT by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.

  11. Our results suggest that Gal-1 and ASPP2 functionally compete in nanocluster for active Ras on the plasma membrane. ASPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  12. ASPP2 suppresses p53 target gene transactivation, promoter occupancy, and endogenous p53 target gene expression in response to DNA damage

  13. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner

  14. Downregulated expression of ASPP2 is associated with hepatocellular carcinoma.

  15. miR-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells.

  16. ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.

  17. ASSP2 expression is lower in cancerous tissues and decreased ASPP2 lead to higher cancer cells proliferation and autophagic flux, which contribute to the gemcitabine resistance.

  18. this study revealed a novel function of ASPP2 in modulating autophagy and apoptosis.

  19. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  20. These results identify previously uncharacterized regions distributed throughout the protein sequence of ASPP2 as determinants of CagA binding, providing mechanistic insight into apoptosis reprogramming by CagA.

Zebrafish Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.

Mouse (Murine) Tumor Protein P53 Binding Protein 2 (TP53BP2) interaction partners

  1. These results suggest that ASPP2 plays an important role in p53-mediated neuronal apoptosis under gp120 stress.

  2. These findings identify TP53BP2 as a strong candidate causative gene for central nervous system (CNS) defects in 1q41q42 microdeletion syndrome.

  3. SPP2 dominates the biological outcome, thus switching from a Gal-1 supported growth-promoting setting to a senescence inducing and stemness suppressive program in cancer cells. Our results support Ras nanocluster as major integrators of tumour fate decision events.

  4. ASPP2 may participate in the lipid metabolism of non-alcoholic steatohepatitis and attenuate liver failure.

  5. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex

  6. findings suggest that the identified STAT1/ASPP2 pathway may connect tumor suppression and cell polarity to neuroinflammation

  7. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.

  8. ASPP2 is a tumor suppressor that suppresses squamous cell carcinoma via inflammatory signaling through NF-kappaB-mediated repression of p63.

  9. Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of retinal ganglion cells.

  10. regulates epithelial cell polarity in cooperation with PAR-3 to form an active PAR complex

  11. Consistent with its role in cell polarity, ASPP2 influences interkinetic nuclear migration and lamination during CNS development.

  12. ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression.

  13. 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates.

  14. ASPP2(+/-) mice appeared developmentally normal, they displayed an increased incidence of a variety of spontaneous tumors as they aged

  15. [review] potential ASPP2-mediated pathways found by gene expression profiling

Tumor Protein P53 Binding Protein 2 (TP53BP2) Antigen Profile

Protein Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TP53BP2

  • tumor protein p53 binding protein 2 (TP53BP2) antibody
  • tumor protein p53 binding protein 2 L homeolog (tp53bp2.L) antibody
  • tumor protein p53 binding protein 2 (tp53bp2) antibody
  • tumor protein p53 binding protein, 2b (tp53bp2b) antibody
  • transformation related protein 53 binding protein 2 (Trp53bp2) antibody
  • tumor protein p53 binding protein, 2 (Tp53bp2) antibody
  • tumor protein p53 binding protein, 2a (tp53bp2a) antibody
  • tumor protein p53 binding protein 2 (Tp53bp2) antibody
  • 53BP2 antibody
  • AI746547 antibody
  • ASPP2 antibody
  • BBP antibody
  • P53BP2 antibody
  • PPP1R13A antibody
  • Tp53bp2 antibody
  • Trp53bp2 antibody
  • wu:fa09h08 antibody
  • wu:fb04e08 antibody
  • X98550 antibody
  • zgc:85720 antibody

Protein level used designations for TP53BP2

BCL2-binding protein , apoptosis-stimulating of p53 protein 2 , apoptosis-stimulating protein of p53, 2 , renal carcinoma antigen NY-REN-51 , tumor suppressor p53-binding protein 2 , tumor protein p53 binding protein, 2 , apoptosis-stimulating of p53 protein 2-like , p53-binding protein 2 , p53BP2 , transformation related protein 53 binding protein 2 , fb04e08

GENE ID SPECIES
7159 Homo sapiens
421329 Gallus gallus
446947 Xenopus laevis
457766 Pan troglodytes
490397 Canis lupus familiaris
514474 Bos taurus
548790 Xenopus (Silurana) tropicalis
568138 Danio rerio
705383 Macaca mulatta
100055278 Equus caballus
100221962 Taeniopygia guttata
100445132 Pongo abelii
100519863 Sus scrofa
209456 Mus musculus
305025 Rattus norvegicus
407983 Danio rerio
100732221 Cavia porcellus
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