anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) Antibodies

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (8) and PTPN22 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPN22 19260 P29352
PTPN22 26191 Q9Y2R2
PTPN22 295338  
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Top anti-PTPN22 Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Flow Cytometry analysis of U937 cells using anti-PTPN22 antibody . Overlay histogram showing U937 cells stained with  (Blue line).The cells were blocked with 10% normal goat serum. And then incubated with rabbit anti-PTPN22 Antibody (,1µg/1x106 cells) for 30 min at 20°C. DyLight®488 conjugated goat anti-rabbit IgG (BA1127, 5-10µg/1x106 cells) was used as secondary antibody for 30 minutes at 20°C. Isotype control antibody (Green line) was rabbit IgG (1µg/1x106) used under the same conditions. Unlabelled sample (Red line) was also used as a control. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Goat Un-conjugated IHC, IHC (p) Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Dog Rabbit Un-conjugated WB Host: Rabbit Target Name: PTPN22 Sample Type: Thyroid Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using PTPN22  Antibody (C-term). This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (45.43 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB ABIN6266761 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis on HeLa cell lysate using PTPN22 Antibody,The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of extracts of Jurkat, using PTPN22 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276672 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB PTPN22 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PTPN22 antibody detected the PTPN22 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$366.77
Details
Human Goat Un-conjugated ELISA, FACS, ICC, IF, IHC, IHC (p), WB Flow Cytometry: Lyp/PTPN22 Antibody  - Analysis of paraformaldehyde fixed Jurkat cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody. Immunohistochemistry-Paraffin: Lyp/PTPN22 Antibody  - (3.75ug/ml) staining of paraffin embedded Human Adrenal Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 7 to 9 Days
$488.73
Details

Top referenced anti-PTPN22 Antibodies

  1. Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622 : Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012 (PubMed)

More Antibodies against PTPN22 Interaction Partners

Mouse (Murine) Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. these findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease

  2. PTPN22 role in CD8-positive t cells activation.

  3. This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.

  4. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 repressor, cAMP-responsive element modulator is reduced.

  5. we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis

  6. Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.

  7. PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.

  8. PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1).

  9. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.

  10. PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

  11. collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals

  12. PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta.

  13. We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.

  14. this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis

  15. report demonstrates enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.

  16. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  17. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.

  18. lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells

  19. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

  20. T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.

Human Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) interaction partners

  1. PTPN22 and CTLA-4 polymorphisms are associated with Autoimmune polyglandular syndromes and differentiate between polyglandular and monoglandular autoimmunity.

  2. gene expression levels of PTPN22 were higher in the alopecia areata patients in Iranian population; association between the PTPN22 genetic variation was not confirmed by this study

  3. The data presented here suggests that the T allele of PTPN-22 C1858T polymorphism might be a risk factor for T1D development in Saudi children.

  4. The variability in PTPN22 haplotypes suggests that the genetic signature of LADA is independent and should not be considered a hybrid form of T1DM and T2DM.

  5. The PTPN22 G788A polymorphism confers protection against systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis. (Meta-analysis)

  6. Data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in Crohn's disease patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria.

  7. the R620W PTPN22 variant seems to be a major risk factor for anti-neutrophil cytoplasmic antibody-associated vasculitis.

  8. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15x10-5, OR=5.07), rs16861329 on 3q27.3 (P=2.02x10-4, OR=0.87) and rs849135 on 7p15.1 (P=6.59x10-9, OR=1.78), which suggested PTPN22, ST6GAL1 and JAZF1 as novel susceptibility genes for psoriasis in Chinese population.

  9. The frequency of STAT4 variant allele was significantly higher in rheumatoid arthritis (RA) patients than in controls, while the variant allele of PTPN22 was identified in only two RA patients, in a heterozygous form and in none of control subjects. The study also found PTPN22 rs2476601 has no role in susceptibility to RA in Egyptian patients.

  10. c.1858CC genotype associated with a beneficial functional effect on residual insulin secretion and HbA1c level dynamics in type 1 diabetes

  11. present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.

  12. There were no significant relationships with PTPN22 SNPs in primary biliary cholangitis (PBC) patients. Interestingly, the AAGTCCC haplotype was significantly associated with resistance to both Autoimmune hepatitis (odds ratio [OR] = 0.58, P = 0.0067) and PBC (OR = 0.58, P = 0.0048). SNPs in the PTPN22 gene may therefore play key roles in the genetic resistance to autoimmune liver disease in the Japanese.

  13. Studied association of and RNASET2, GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 were significantly associated with altered GD-derived LD risk.

  14. PTPN22 is hypermethylated in esophageal squamous cell carcinoma

  15. A higher prevalence of homozygous PTPN22 -1123CC genotype was found in controls than in rheumatoid arthritis (RA) patients, suggesting a potential protective effect against RA. Concerning anti-cyclic citrullinated protein antibodies levels, the CC genotype carriers showed the lowest median levels in RA.

  16. Our data provide the first demonstration that PTPN22 R620W confers Graves Disease susceptibility among Latin-American patients.

  17. The GG genotype of PTPN22 rs6665194 (-3508A>G) is associated with significantly reduced risk of Rheumatoid Arthritis in Asians.

  18. PTPN22 rs2476601 was related to systemic lupus erythematosus in Americans, Europeans, and Africans.[meta-analysis]

  19. the rs1310182 SNP of the PTPN22 gene may be a predisposing factor of celiac disease in the Iranian population

  20. PTPN22 polymorphisms may have a role in risk of ankylosing spondylilitis [meta-analysis]

PTPN22 Antigen Profile

Protein Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PTPN22

  • protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22) antibody
  • protein tyrosine phosphatase, non-receptor type 22 (PTPN22) antibody
  • protein tyrosine phosphatase, non-receptor type 22 (Ptpn22) antibody
  • 70zpep antibody
  • LYP antibody
  • LYP1 antibody
  • LYP2 antibody
  • PEP antibody
  • PTPN8 antibody

Protein level used designations for PTPN22

PEST domain-enriched tyrosine phosphatase , hematopoietic cell protein-tyrosine phosphatase 70Z-PEP , protein tyrosine phosphatase, non-receptor type 8 , tyrosine-protein phosphatase non-receptor type 22 , PEST-domain phosphatase , lymphoid phosphatase , lymphoid-specific protein tyrosine phosphatase

GENE ID SPECIES
19260 Mus musculus
26191 Homo sapiens
295338 Rattus norvegicus
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