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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (8) and PTPN22 Kits (2) and many more products for this protein.
Showing 10 out of 75 products:
Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622
Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012
This finding shows that autophagy and NLRP3 (show NLRP3 Antibodies) inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.
Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 (show CD4 Antibodies) T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 (show IL2 Antibodies) repressor, cAMP-responsive element modulator (show CREM Antibodies) is reduced.
we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis
Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (show TYRP1 Antibodies) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.
PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (show IFNA Antibodies) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.
PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (show ITGAL Antibodies) ligand intercellular adhesion molecule-1 (ICAM-1 (show ICAM1 Antibodies)).
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Antibodies) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).
We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15x10-5, OR=5.07), rs16861329 on 3q27.3 (P=2.02x10-4, OR=0.87) and rs849135 on 7p15.1 (P=6.59x10-9, OR=1.78), which suggested PTPN22, ST6GAL1 (show ST6GAL1 Antibodies) and JAZF1 (show JAZF1 Antibodies) as novel susceptibility genes for psoriasis in Chinese population.
The frequency of STAT4 (show STAT4 Antibodies) variant allele was significantly higher in rheumatoid arthritis (RA) patients than in controls, while the variant allele of PTPN22 was identified in only two RA patients, in a heterozygous form and in none of control subjects. The study also found PTPN22 rs2476601 has no role in susceptibility to RA in Egyptian patients.
c.1858CC genotype associated with a beneficial functional effect on residual insulin (show INS Antibodies) secretion and HbA1c level dynamics in type 1 diabetes
present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.
There were no significant relationships with PTPN22 SNPs in primary biliary cholangitis (PBC (show DLAT Antibodies)) patients. Interestingly, the AAGTCCC haplotype was significantly associated with resistance to both Autoimmune hepatitis (odds ratio [OR] = 0.58, P = 0.0067) and PBC (show DLAT Antibodies) (OR = 0.58, P = 0.0048). SNPs in the PTPN22 gene may therefore play key roles in the genetic resistance to autoimmune liver disease in the Japanese.
Studied association of and RNASET2 (show RNASET2 Antibodies), GPR174 (show GPR174 Antibodies), and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 (show GPR174 Antibodies) rs3827440, PTPN22 rs3789604, and RNASET2 (show RNASET2 Antibodies) rs9355610 were significantly associated with altered GD-derived LD risk.
PTPN22 is hypermethylated in esophageal squamous cell carcinoma
A higher prevalence of homozygous PTPN22 -1123CC genotype was found in controls than in rheumatoid arthritis (RA) patients, suggesting a potential protective effect against RA. Concerning anti-cyclic citrullinated protein antibodies levels, the CC genotype carriers showed the lowest median levels in RA.
Our data provide the first demonstration that PTPN22 R620W confers Graves Disease susceptibility among Latin-American patients.
The GG genotype of PTPN22 rs6665194 (-3508A>G) is associated with significantly reduced risk of Rheumatoid Arthritis in Asians.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase