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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Proteins (6) and PTPN22 Kits (1) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal PTPN22 Primary Antibody for WB - ABIN525622
Cao, Yang, Colby, Hogan, Hu, Jennette, Berg, Zhang, Jennette, Falk, Preston: High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. in PLoS ONE 2012
Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 (show CD4 Antibodies) T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 (show IL2 Antibodies) repressor, cAMP-responsive element modulator (show CREM Antibodies) is reduced.
we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis
Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (show TYRP1 Antibodies) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.
PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (show IFNA Antibodies) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.
PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (show ITGAL Antibodies) ligand intercellular adhesion molecule-1 (ICAM-1 (show ICAM1 Antibodies)).
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (show NLRP3 Antibodies) phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).
We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.
Our data provide the first demonstration that PTPN22 R620W confers Graves Disease susceptibility among Latin-American patients.
The GG genotype of PTPN22 rs6665194 (-3508A>G) is associated with significantly reduced risk of Rheumatoid Arthritis in Asians.
PTPN22 rs2476601 was related to systemic lupus erythematosus in Americans, Europeans, and Africans.[meta-analysis]
the rs1310182 SNP of the PTPN22 gene may be a predisposing factor of celiac disease in the Iranian population
PTPN22 polymorphisms may have a role in risk of ankylosing spondylilitis [meta-analysis]
Analysis of PTPN22, ZFAT (show ZFAT Antibodies) and MYO9B (show MYO9B Antibodies) polymorphisms in Turner Syndrome and risk of autoimmune disease.
Our study supports an association between the PTPN22 gene polymorphism rs2476601 and an increased risk for Type 1 diabetes in children
PTPN22 single nucleotide polymorphism is associated with type 1 diabetes in Iran
Relationship with insulin (show INS Antibodies)-dependent diabetes mellitus was found only in polymorphism R620W
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase