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U2AF1 belongs to the splicing factor SR family of genes. Additionally we are shipping U2AF1 Proteins (7) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal U2AF1 Primary Antibody for ICC, IF - ABIN438948
Wang, Wilson-Berry, Schedl, Hansen: TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. in Developmental dynamics : an official publication of the American Association of Anatomists 2012
Human Polyclonal U2AF1 Primary Antibody for ICC, IF - ABIN4363831
Stadler, Fagerberg, Sivertsson, Oksvold, Zwahlen, Hallström, Lundberg, Uhlén: RNA- and antibody-based profiling of the human proteome with focus on chromosome 19. in Journal of proteome research 2014
The U2AF35(S34F) mutation alters interaction with CFIm59 (show CPSF7 Antibodies), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 (show ATG7 Antibodies) pre-mRNA, decreasing levels of ATG7 (show ATG7 Antibodies) protein and defective autophagy, ultimately leading to transformation.
data support the impact of genes from the Abcg1 (show ABCG1 Antibodies)-U2af1 region as modifiers of Tc1 (show C8orf4 Antibodies)-dependent memory and locomotor phenotypes in Tc1 (show C8orf4 Antibodies) mouse model of Down syndrome.
findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS (show MECOM Antibodies)
this study establishes definitely the contribution of the Abcg1 (show ABCG1 Antibodies)-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.
data confirm MLL (show MLL Antibodies)-PTD (show BCS1L Antibodies) and, to a lesser extent, FLT3 (show FLT3 Antibodies)-ITD as common events in +11 AML (show RUNX1 Antibodies).6, 7, 8 However, the high mutation frequencies of U2AF1 and genes involved in methylation (DNMT3A (show DNMT3A Antibodies), IDH2 (show IDH2 Antibodies)) have hitherto not been reported in +11 AML (show RUNX1 Antibodies)
this study characterized novel candidate pediatric T-cell acute lymphoblastic leukemia driver mutation in splicesome factor U2AF1
U2AF35 missense mutation is associated with alternative 5' splice site that impacts splicing regulation in cancer.
The frequently mutated SF3B1 (show SF3B2 Antibodies) residues contact the pre-mRNA splice site. Based on structural homology with other spliceosome subunits, and recent findings of altered RNA binding by mutant U2AF1 proteins, we suggest that affected U2AF1 residues also contact pre-mRNA.
The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (show SLU7 Antibodies) genes in myelodysplastic syndromes (SF3B1 (show SF3B2 Antibodies), SRSF2 (show SRSF2 Antibodies) and U2AF1) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)
infer that U2AF1 S34 mutations characterize a distinct subgroup of myelodysplastic syndrome
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons controlled by SRF3.
Our results provide mechanistic explanations of the magnitude of splicing changes observed in U2AF1-mutant cells and why tumors harboring U2AF1 mutations always retain an expressed copy of the wild-type allele
Mutations in ASXL1 (show ASXL1 Antibodies), U2AF1, and SF3B1 (show SF3B2 Antibodies) are common in Chinese patients with myelodysplastic syndromes.
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
U2 small nuclear RNA auxiliary factor 1
, RNA recognition motif-containing protein RRM
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor small subunit
, U2(RNU2) small nuclear RNA auxiliary factor 1
, U2 auxiliary factor 35 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa
, splicing factor U2AF 35 kDa subunit
, U2 small nuclear RNA auxillary factor 1
, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
, U2(RNU2) small nuclear RNA auxiliary factor binding protein
, splicing factor U2AF 35kDa subunit
, U2snRNP auxiliary factor small subunit
, uncharacterized protein LOC687575
, U2(RNU2) small nuclear RNA auxillary factor 1